Abstract
The present study characterized subpopulations of T lymphocytes from patients with sarcoidosis by the presence of Fc receptors for either IgG or IgM. There was a consistent reduction in the total number of circulating T cells. The percentage of T lymphocytes with receptors for the Fc portion of IgG (TG) was significantly increased and the percentage of T cells bearing receptors for IgM (TM) was significantly decreased when compared to control values. There was no change in the proportion of cells which lacked either receptor (TNON-G NON-M). The absolute numbers of each T-lymphocyte subpopulation were diminished but TG cells were less severely reduced than either TM or TNON-G NON-M. Thus, there is a disproportionate reduction in distinct subpopulations of T lymphocytes in patients with sarcoidosis which results in a relative increase in TG lymphocytes and a relative decrease in TM lymphocytes. Such alterations in lymphocyte subpopulations may explain some of the immunological aberrancies characteristic of sarcoidosis.
Original language | English (US) |
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Pages (from-to) | 350-354 |
Number of pages | 5 |
Journal | Clinical Immunology and Immunopathology |
Volume | 10 |
Issue number | 3 |
DOIs | |
State | Published - Jul 1978 |
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine
- Immunology