Alteration of T-lymphocyte subpopulations in sarcoidosis

Paul Katz, Barton F. Haynes, Anthony S. Fauci

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The present study characterized subpopulations of T lymphocytes from patients with sarcoidosis by the presence of Fc receptors for either IgG or IgM. There was a consistent reduction in the total number of circulating T cells. The percentage of T lymphocytes with receptors for the Fc portion of IgG (TG) was significantly increased and the percentage of T cells bearing receptors for IgM (TM) was significantly decreased when compared to control values. There was no change in the proportion of cells which lacked either receptor (TNON-G NON-M). The absolute numbers of each T-lymphocyte subpopulation were diminished but TG cells were less severely reduced than either TM or TNON-G NON-M. Thus, there is a disproportionate reduction in distinct subpopulations of T lymphocytes in patients with sarcoidosis which results in a relative increase in TG lymphocytes and a relative decrease in TM lymphocytes. Such alterations in lymphocyte subpopulations may explain some of the immunological aberrancies characteristic of sarcoidosis.

Original languageEnglish (US)
Pages (from-to)350-354
Number of pages5
JournalClinical Immunology and Immunopathology
Volume10
Issue number3
DOIs
StatePublished - Jul 1978

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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