The present study characterized subpopulations of T lymphocytes from patients with sarcoidosis by the presence of Fc receptors for either IgG or IgM. There was a consistent reduction in the total number of circulating T cells. The percentage of T lymphocytes with receptors for the Fc portion of IgG (TG) was significantly increased and the percentage of T cells bearing receptors for IgM (TM) was significantly decreased when compared to control values. There was no change in the proportion of cells which lacked either receptor (TNON-G NON-M). The absolute numbers of each T-lymphocyte subpopulation were diminished but TG cells were less severely reduced than either TM or TNON-G NON-M. Thus, there is a disproportionate reduction in distinct subpopulations of T lymphocytes in patients with sarcoidosis which results in a relative increase in TG lymphocytes and a relative decrease in TM lymphocytes. Such alterations in lymphocyte subpopulations may explain some of the immunological aberrancies characteristic of sarcoidosis.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine