Alteration of prostaglandin biosynthesis in rat chloroleukemic tumor

V. A. Ziboh, J. T. Lord, G. Blick, I. Kursunoglu, Adel A Yunis, A. A. Yunis

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Abstract

Data from the authors' present studies demonstrate the capability of a 105,000xg pellet from rat normal bone marrow, turpentine-induced hyperplastic bone marrow, and chloroma tumor to transform precursor arachidonic acid into prostaglandins. The activity of the prostaglandin synthetase systems in these tissues is inhibited by the known nonsteroid antiinflammatory drug indomethacin and by two unsaturated fatty acids previously demonstrated in other tissues. Although the overall biosynthesis of prostaglandin E 2 (PGE 2) was higher in the hyperplastic bone marrow than in the chloroma tumor, the PGF(2α):PGE 2 ratio was markedly higher (8-fold) in the chloroma tissue. This latter increase was probably due to the increased transformation of PGE 2 into PGF(2α) by the NADPH-dependent PGE 2 9-ketoreductase (an enzyme that catalyzes the transformation PGE 2 and PGF(2α)). These results indicate the greater capability of the malignant chloroma tissue to form PGF(2α) than of nonmalignant hyperplastic bone marrow. Although the role of PGF(2α) in the malignant myelogenous leukemic tumor is presently unclear, its increased formation in this tissue suggests that this substance may play a role in the hyperproliferative process.

Original languageEnglish (US)
Pages (from-to)3974-3980
Number of pages7
JournalCancer Research
Volume37
Issue number11
StatePublished - 1977

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Myeloid Sarcoma
Prostaglandins F
Prostaglandins E
Prostaglandins
Bone Marrow
Neoplasms
Turpentine
Prostaglandin-Endoperoxide Synthases
Unsaturated Fatty Acids
NADP
Arachidonic Acid
Indomethacin
Anti-Inflammatory Agents
Enzymes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ziboh, V. A., Lord, J. T., Blick, G., Kursunoglu, I., Yunis, A. A., & Yunis, A. A. (1977). Alteration of prostaglandin biosynthesis in rat chloroleukemic tumor. Cancer Research, 37(11), 3974-3980.

Alteration of prostaglandin biosynthesis in rat chloroleukemic tumor. / Ziboh, V. A.; Lord, J. T.; Blick, G.; Kursunoglu, I.; Yunis, Adel A; Yunis, A. A.

In: Cancer Research, Vol. 37, No. 11, 1977, p. 3974-3980.

Research output: Contribution to journalArticle

Ziboh, VA, Lord, JT, Blick, G, Kursunoglu, I, Yunis, AA & Yunis, AA 1977, 'Alteration of prostaglandin biosynthesis in rat chloroleukemic tumor', Cancer Research, vol. 37, no. 11, pp. 3974-3980.
Ziboh VA, Lord JT, Blick G, Kursunoglu I, Yunis AA, Yunis AA. Alteration of prostaglandin biosynthesis in rat chloroleukemic tumor. Cancer Research. 1977;37(11):3974-3980.
Ziboh, V. A. ; Lord, J. T. ; Blick, G. ; Kursunoglu, I. ; Yunis, Adel A ; Yunis, A. A. / Alteration of prostaglandin biosynthesis in rat chloroleukemic tumor. In: Cancer Research. 1977 ; Vol. 37, No. 11. pp. 3974-3980.
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