Alteration in virulence characteristics of biofilm cells of Pseudomonas aeruginosa in presence of Tamm-Horsfall protein

Rahul Mittal, Saroj Sharma, Sanjay Chhibber, Kusum Harjai

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Tamm-Horsfall glycoprotein is the most abundant protein in human urine. The present investigation was planned to study the effect of Tamm-Horsfall protein (THP) on elaboration of virulence factors by biofilm cells of Pseudomonas aeruginosa. It was observed that with increase in concentration of THP from 10 to 50 μg/ml there was significant enhancement in elaboration of all the virulence factors by biofilm cells of P. aeruginosa. However, with further increase in concentration of THP from 50 to 70 μg/ml, significant decrease in elaboration of all the virulence traits was observed. Implications of these findings in relation to urinary tract infections caused by P. aeruginosa have been discussed.

Original languageEnglish (US)
Pages (from-to)915-919
Number of pages5
JournalWorld Journal of Microbiology and Biotechnology
Volume22
Issue number9
DOIs
StatePublished - Sep 2006
Externally publishedYes

Keywords

  • Biofilms
  • Pseudomonas aeruginosa
  • Tamm-Horsfall protein
  • Urinary tract infections
  • Virulence factors

ASJC Scopus subject areas

  • Biotechnology
  • Physiology
  • Applied Microbiology and Biotechnology

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