Alpha-II-spectrin after controlled cortical impact in the immature rat brain

J. Aikman, B. O'Steen, X. Silver, R. Torres, S. Boslaugh, S. Blackband, K. Padgett, K. K.W. Wang, R. Hayes, J. Pineda

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Proteolytic processing plays an important role in regulating a wide range of important cellular functions, including processing of cytoskeletal proteins. Loss of cytoskeletal proteins such as spectrin is an important characteristic in a variety of acute central nervous system injuries including ischemia, spinal cord injury and traumatic brain injury (TBI). The literature contains extensive information on the proteolytic degradation of alpha-II-spectrin after TBI in the adult brain. By contrast, there is limited knowledge on the characteristics and relevance of these important processes in the immature brain. The present experiments examine TBI-induced proteolytic processing of alpha-II-spectrin after TBI in the immature rat brain. Distinct proteolytic products resulting from the degradation of the cytoskeletal protein alpha-II-spectrin by calpain and caspase 3 were readily detectable in cortical brain parenchyma and cerebrospinal fluid after TBI in immature rats.

Original languageEnglish (US)
Pages (from-to)457-465
Number of pages9
JournalDevelopmental Neuroscience
Volume28
Issue number4-5
DOIs
StatePublished - Aug 2006

Keywords

  • Cerebrospinal fluid
  • Developing brain
  • Magnetic resonance imaging
  • Pediatric traumatic brain injury
  • Spectrin

ASJC Scopus subject areas

  • Neuroscience(all)

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    Aikman, J., O'Steen, B., Silver, X., Torres, R., Boslaugh, S., Blackband, S., Padgett, K., Wang, K. K. W., Hayes, R., & Pineda, J. (2006). Alpha-II-spectrin after controlled cortical impact in the immature rat brain. Developmental Neuroscience, 28(4-5), 457-465. https://doi.org/10.1159/000094171