Alpha-II-spectrin after controlled cortical impact in the immature rat brain

J. Aikman, B. O'Steen, X. Silver, R. Torres, S. Boslaugh, S. Blackband, Kyle Padgett, K. K W Wang, R. Hayes, J. Pineda

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Proteolytic processing plays an important role in regulating a wide range of important cellular functions, including processing of cytoskeletal proteins. Loss of cytoskeletal proteins such as spectrin is an important characteristic in a variety of acute central nervous system injuries including ischemia, spinal cord injury and traumatic brain injury (TBI). The literature contains extensive information on the proteolytic degradation of alpha-II-spectrin after TBI in the adult brain. By contrast, there is limited knowledge on the characteristics and relevance of these important processes in the immature brain. The present experiments examine TBI-induced proteolytic processing of alpha-II-spectrin after TBI in the immature rat brain. Distinct proteolytic products resulting from the degradation of the cytoskeletal protein alpha-II-spectrin by calpain and caspase 3 were readily detectable in cortical brain parenchyma and cerebrospinal fluid after TBI in immature rats.

Original languageEnglish
Pages (from-to)457-465
Number of pages9
JournalDevelopmental Neuroscience
Volume28
Issue number4-5
DOIs
StatePublished - Aug 1 2006
Externally publishedYes

Fingerprint

Spectrin
Cytoskeletal Proteins
Brain
Nervous System Trauma
Calpain
Spinal Cord Injuries
Caspase 3
Cerebrospinal Fluid
Ischemia
Central Nervous System
Traumatic Brain Injury

Keywords

  • Cerebrospinal fluid
  • Developing brain
  • Magnetic resonance imaging
  • Pediatric traumatic brain injury
  • Spectrin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Aikman, J., O'Steen, B., Silver, X., Torres, R., Boslaugh, S., Blackband, S., ... Pineda, J. (2006). Alpha-II-spectrin after controlled cortical impact in the immature rat brain. Developmental Neuroscience, 28(4-5), 457-465. https://doi.org/10.1159/000094171

Alpha-II-spectrin after controlled cortical impact in the immature rat brain. / Aikman, J.; O'Steen, B.; Silver, X.; Torres, R.; Boslaugh, S.; Blackband, S.; Padgett, Kyle; Wang, K. K W; Hayes, R.; Pineda, J.

In: Developmental Neuroscience, Vol. 28, No. 4-5, 01.08.2006, p. 457-465.

Research output: Contribution to journalArticle

Aikman, J, O'Steen, B, Silver, X, Torres, R, Boslaugh, S, Blackband, S, Padgett, K, Wang, KKW, Hayes, R & Pineda, J 2006, 'Alpha-II-spectrin after controlled cortical impact in the immature rat brain', Developmental Neuroscience, vol. 28, no. 4-5, pp. 457-465. https://doi.org/10.1159/000094171
Aikman J, O'Steen B, Silver X, Torres R, Boslaugh S, Blackband S et al. Alpha-II-spectrin after controlled cortical impact in the immature rat brain. Developmental Neuroscience. 2006 Aug 1;28(4-5):457-465. https://doi.org/10.1159/000094171
Aikman, J. ; O'Steen, B. ; Silver, X. ; Torres, R. ; Boslaugh, S. ; Blackband, S. ; Padgett, Kyle ; Wang, K. K W ; Hayes, R. ; Pineda, J. / Alpha-II-spectrin after controlled cortical impact in the immature rat brain. In: Developmental Neuroscience. 2006 ; Vol. 28, No. 4-5. pp. 457-465.
@article{0ebd16796bde42a3ba89cb536d539bcb,
title = "Alpha-II-spectrin after controlled cortical impact in the immature rat brain",
abstract = "Proteolytic processing plays an important role in regulating a wide range of important cellular functions, including processing of cytoskeletal proteins. Loss of cytoskeletal proteins such as spectrin is an important characteristic in a variety of acute central nervous system injuries including ischemia, spinal cord injury and traumatic brain injury (TBI). The literature contains extensive information on the proteolytic degradation of alpha-II-spectrin after TBI in the adult brain. By contrast, there is limited knowledge on the characteristics and relevance of these important processes in the immature brain. The present experiments examine TBI-induced proteolytic processing of alpha-II-spectrin after TBI in the immature rat brain. Distinct proteolytic products resulting from the degradation of the cytoskeletal protein alpha-II-spectrin by calpain and caspase 3 were readily detectable in cortical brain parenchyma and cerebrospinal fluid after TBI in immature rats.",
keywords = "Cerebrospinal fluid, Developing brain, Magnetic resonance imaging, Pediatric traumatic brain injury, Spectrin",
author = "J. Aikman and B. O'Steen and X. Silver and R. Torres and S. Boslaugh and S. Blackband and Kyle Padgett and Wang, {K. K W} and R. Hayes and J. Pineda",
year = "2006",
month = "8",
day = "1",
doi = "10.1159/000094171",
language = "English",
volume = "28",
pages = "457--465",
journal = "Developmental Neuroscience",
issn = "0378-5866",
publisher = "S. Karger AG",
number = "4-5",

}

TY - JOUR

T1 - Alpha-II-spectrin after controlled cortical impact in the immature rat brain

AU - Aikman, J.

AU - O'Steen, B.

AU - Silver, X.

AU - Torres, R.

AU - Boslaugh, S.

AU - Blackband, S.

AU - Padgett, Kyle

AU - Wang, K. K W

AU - Hayes, R.

AU - Pineda, J.

PY - 2006/8/1

Y1 - 2006/8/1

N2 - Proteolytic processing plays an important role in regulating a wide range of important cellular functions, including processing of cytoskeletal proteins. Loss of cytoskeletal proteins such as spectrin is an important characteristic in a variety of acute central nervous system injuries including ischemia, spinal cord injury and traumatic brain injury (TBI). The literature contains extensive information on the proteolytic degradation of alpha-II-spectrin after TBI in the adult brain. By contrast, there is limited knowledge on the characteristics and relevance of these important processes in the immature brain. The present experiments examine TBI-induced proteolytic processing of alpha-II-spectrin after TBI in the immature rat brain. Distinct proteolytic products resulting from the degradation of the cytoskeletal protein alpha-II-spectrin by calpain and caspase 3 were readily detectable in cortical brain parenchyma and cerebrospinal fluid after TBI in immature rats.

AB - Proteolytic processing plays an important role in regulating a wide range of important cellular functions, including processing of cytoskeletal proteins. Loss of cytoskeletal proteins such as spectrin is an important characteristic in a variety of acute central nervous system injuries including ischemia, spinal cord injury and traumatic brain injury (TBI). The literature contains extensive information on the proteolytic degradation of alpha-II-spectrin after TBI in the adult brain. By contrast, there is limited knowledge on the characteristics and relevance of these important processes in the immature brain. The present experiments examine TBI-induced proteolytic processing of alpha-II-spectrin after TBI in the immature rat brain. Distinct proteolytic products resulting from the degradation of the cytoskeletal protein alpha-II-spectrin by calpain and caspase 3 were readily detectable in cortical brain parenchyma and cerebrospinal fluid after TBI in immature rats.

KW - Cerebrospinal fluid

KW - Developing brain

KW - Magnetic resonance imaging

KW - Pediatric traumatic brain injury

KW - Spectrin

UR - http://www.scopus.com/inward/record.url?scp=33748150497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748150497&partnerID=8YFLogxK

U2 - 10.1159/000094171

DO - 10.1159/000094171

M3 - Article

VL - 28

SP - 457

EP - 465

JO - Developmental Neuroscience

JF - Developmental Neuroscience

SN - 0378-5866

IS - 4-5

ER -