Abstract
Administration to rats of dietary lithium for 30 days was followed by evaluation of alpha-1 adrenergic receptor binding and of adrenergic-stimulated cyclic AMP (cAMP) accumulation in rat cerebral cortex. Chronic lithium treatment did not alter the binding characteristics of [3H]prazosin or the proportion of alpha-1 adrenergic receptor subtypes distinguished by chlorethylclonidine (CEC) pretreatment in rat cerebral cortical membranes. Accumulation of cAMP in cortical slices incubated with adrenergic agonists was unaffected in lithium-treated rats. These results demonstrate that chronic lithium treatment-induced reduction of norepinephrine (NE)-stimulated phosphoinositide (PI) hydrolysis (Casebolt and Jope, 1987) is not due to changes in the alpha-1 adrenergic receptor and is more sensitive to in vivo lithium treatment than is adrenergic-stimulated cAMP accumulation.
Original language | English (US) |
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Pages (from-to) | 197-204 |
Number of pages | 8 |
Journal | Journal of Neural Transmission |
Volume | 82 |
Issue number | 3 |
DOIs | |
State | Published - Oct 1990 |
Externally published | Yes |
Keywords
- alpha adrenergic receptor
- chlorethylclonidine
- cyclic AMP
- Lithium
ASJC Scopus subject areas
- Neuroscience(all)