Alpha-1 adrenergic receptor binding and adrenergic-stimulated cyclic AMP production in rat cerebral cortex after chronic lithium treatment

T. L. Casebolt, Xiaohua Li, Richard S Jope

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Administration to rats of dietary lithium for 30 days was followed by evaluation of alpha-1 adrenergic receptor binding and of adrenergic-stimulated cyclic AMP (cAMP) accumulation in rat cerebral cortex. Chronic lithium treatment did not alter the binding characteristics of [3H]prazosin or the proportion of alpha-1 adrenergic receptor subtypes distinguished by chlorethylclonidine (CEC) pretreatment in rat cerebral cortical membranes. Accumulation of cAMP in cortical slices incubated with adrenergic agonists was unaffected in lithium-treated rats. These results demonstrate that chronic lithium treatment-induced reduction of norepinephrine (NE)-stimulated phosphoinositide (PI) hydrolysis (Casebolt and Jope, 1987) is not due to changes in the alpha-1 adrenergic receptor and is more sensitive to in vivo lithium treatment than is adrenergic-stimulated cAMP accumulation.

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalJournal of Neural Transmission
Volume82
Issue number3
DOIs
StatePublished - Oct 1 1990
Externally publishedYes

Fingerprint

Adrenergic alpha-1 Receptors
Lithium
Cerebral Cortex
Cyclic AMP
Adrenergic Agents
Adrenergic Agonists
Prazosin
Phosphatidylinositols
Norepinephrine
Hydrolysis
Membranes

Keywords

  • alpha adrenergic receptor
  • chlorethylclonidine
  • cyclic AMP
  • Lithium

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alpha-1 adrenergic receptor binding and adrenergic-stimulated cyclic AMP production in rat cerebral cortex after chronic lithium treatment. / Casebolt, T. L.; Li, Xiaohua; Jope, Richard S.

In: Journal of Neural Transmission, Vol. 82, No. 3, 01.10.1990, p. 197-204.

Research output: Contribution to journalArticle

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