Alpha-1 adrenergic receptor binding and adrenergic-stimulated cyclic AMP production in rat cerebral cortex after chronic lithium treatment

T. L. Casebolt; Xiaohua Li; R. S. Jope

doi:10.1007/BF01272762

Alpha-1 adrenergic receptor binding and adrenergic-stimulated cyclic AMP production in rat cerebral cortex after chronic lithium treatment

T. L. Casebolt, Xiaohua Li, R. S. Jope

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Administration to rats of dietary lithium for 30 days was followed by evaluation of alpha-1 adrenergic receptor binding and of adrenergic-stimulated cyclic AMP (cAMP) accumulation in rat cerebral cortex. Chronic lithium treatment did not alter the binding characteristics of [³H]prazosin or the proportion of alpha-1 adrenergic receptor subtypes distinguished by chlorethylclonidine (CEC) pretreatment in rat cerebral cortical membranes. Accumulation of cAMP in cortical slices incubated with adrenergic agonists was unaffected in lithium-treated rats. These results demonstrate that chronic lithium treatment-induced reduction of norepinephrine (NE)-stimulated phosphoinositide (PI) hydrolysis (Casebolt and Jope, 1987) is not due to changes in the alpha-1 adrenergic receptor and is more sensitive to in vivo lithium treatment than is adrenergic-stimulated cAMP accumulation.

Original language	English (US)
Pages (from-to)	197-204
Number of pages	8
Journal	Journal of Neural Transmission
Volume	82
Issue number	3
DOIs	https://doi.org/10.1007/BF01272762
State	Published - Oct 1990
Externally published	Yes

Keywords

alpha adrenergic receptor
chlorethylclonidine
cyclic AMP
Lithium

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1007/BF01272762

Cite this

@article{992765387afc4ac2b9667bf5c0c5d888,

title = "Alpha-1 adrenergic receptor binding and adrenergic-stimulated cyclic AMP production in rat cerebral cortex after chronic lithium treatment",

abstract = "Administration to rats of dietary lithium for 30 days was followed by evaluation of alpha-1 adrenergic receptor binding and of adrenergic-stimulated cyclic AMP (cAMP) accumulation in rat cerebral cortex. Chronic lithium treatment did not alter the binding characteristics of [3H]prazosin or the proportion of alpha-1 adrenergic receptor subtypes distinguished by chlorethylclonidine (CEC) pretreatment in rat cerebral cortical membranes. Accumulation of cAMP in cortical slices incubated with adrenergic agonists was unaffected in lithium-treated rats. These results demonstrate that chronic lithium treatment-induced reduction of norepinephrine (NE)-stimulated phosphoinositide (PI) hydrolysis (Casebolt and Jope, 1987) is not due to changes in the alpha-1 adrenergic receptor and is more sensitive to in vivo lithium treatment than is adrenergic-stimulated cAMP accumulation.",

keywords = "alpha adrenergic receptor, chlorethylclonidine, cyclic AMP, Lithium",

author = "Casebolt, {T. L.} and Xiaohua Li and Jope, {R. S.}",

year = "1990",

month = oct,

doi = "10.1007/BF01272762",

language = "English (US)",

volume = "82",

pages = "197--204",

journal = "Journal of Neural Transmission",

issn = "0300-9564",

publisher = "Springer Verlag",

number = "3",

}

TY - JOUR

T1 - Alpha-1 adrenergic receptor binding and adrenergic-stimulated cyclic AMP production in rat cerebral cortex after chronic lithium treatment

AU - Casebolt, T. L.

AU - Li, Xiaohua

AU - Jope, R. S.

PY - 1990/10

Y1 - 1990/10

N2 - Administration to rats of dietary lithium for 30 days was followed by evaluation of alpha-1 adrenergic receptor binding and of adrenergic-stimulated cyclic AMP (cAMP) accumulation in rat cerebral cortex. Chronic lithium treatment did not alter the binding characteristics of [3H]prazosin or the proportion of alpha-1 adrenergic receptor subtypes distinguished by chlorethylclonidine (CEC) pretreatment in rat cerebral cortical membranes. Accumulation of cAMP in cortical slices incubated with adrenergic agonists was unaffected in lithium-treated rats. These results demonstrate that chronic lithium treatment-induced reduction of norepinephrine (NE)-stimulated phosphoinositide (PI) hydrolysis (Casebolt and Jope, 1987) is not due to changes in the alpha-1 adrenergic receptor and is more sensitive to in vivo lithium treatment than is adrenergic-stimulated cAMP accumulation.

AB - Administration to rats of dietary lithium for 30 days was followed by evaluation of alpha-1 adrenergic receptor binding and of adrenergic-stimulated cyclic AMP (cAMP) accumulation in rat cerebral cortex. Chronic lithium treatment did not alter the binding characteristics of [3H]prazosin or the proportion of alpha-1 adrenergic receptor subtypes distinguished by chlorethylclonidine (CEC) pretreatment in rat cerebral cortical membranes. Accumulation of cAMP in cortical slices incubated with adrenergic agonists was unaffected in lithium-treated rats. These results demonstrate that chronic lithium treatment-induced reduction of norepinephrine (NE)-stimulated phosphoinositide (PI) hydrolysis (Casebolt and Jope, 1987) is not due to changes in the alpha-1 adrenergic receptor and is more sensitive to in vivo lithium treatment than is adrenergic-stimulated cAMP accumulation.

KW - alpha adrenergic receptor

KW - chlorethylclonidine

KW - cyclic AMP

KW - Lithium

UR - http://www.scopus.com/inward/record.url?scp=0025088710&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025088710&partnerID=8YFLogxK

U2 - 10.1007/BF01272762

DO - 10.1007/BF01272762

M3 - Article

C2 - 1979002

AN - SCOPUS:0025088710

VL - 82

SP - 197

EP - 204

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

SN - 0300-9564

IS - 3

ER -

Alpha-1 adrenergic receptor binding and adrenergic-stimulated cyclic AMP production in rat cerebral cortex after chronic lithium treatment

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this