Allosensitization and outcomes in pediatric heart transplantation

William T. Mahle, Margaret A. Tresler, R. Erik Edens, Paolo Rusconi, James F. George, David C. Naftel, Robert E. Shaddy

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Background: Allosensitization among children being considered for heart transplantation remains a great challenge. Controversy exists as to the best approach for those with elevated panel-reactive antibody (PRA) titers. We sought to define the association between elevated PRA and outcomes using data from the multi-institutional Pediatric Heart Transplant Study Group. Methods: Between January 1993 and December 2008, 3,016 patients (>1 month of age) were listed for heart transplantation. PRA data at listing were available for 2,500 (83%) patients, and 2,237 underwent transplantation with PRA data being available for 1,904 (85%). Because various PRA assays were employed (e.g., cell-based and solid phase) we entered the highest value regardless of methodology. Results: Among the factors associated with high PRA at transplant were Status 1 at listing, previous sternotomy and prior Norwood procedure. An elevated PRA at listing was associated with higher risk of death while waiting. Of subjects with PRA <50% only 57% were transplanted by 1 year on the waitlist, as compared with 76% of those with PRA <10%. Waitlist mortality for the highly allosensitized subjects (<PRA 50%) was 19% by 12 months. Survival at 1 year after transplantation was significantly lower in those with PRA <50% versus those with PRA <10% (73% vs 90%, respectively, p < 0.0001). Those with elevated PRA who had a negative prospective crossmatch had no difference in survival compared with those without allosensitization. There was no significant association between PRA levels and time to first rejection or development of coronary allograft vasculopathy. Conclusions: Significant allosensitization is associated with more than a 2-fold increased risk of death within the first transplant year. Although prospective crossmatching abrogates the risk of post-transplant mortality, it may contribute to higher pre-transplant attrition due to longer waitlist times. There is a critical need for strategies to minimize the impact of allosensitization and antibody-mediated rejection immediately after transplantation.

Original languageEnglish
Pages (from-to)1221-1227
Number of pages7
JournalJournal of Heart and Lung Transplantation
Volume30
Issue number11
DOIs
StatePublished - Nov 1 2011

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Keywords

  • allosensitization
  • antibody-mediated rejection
  • heart transplantation
  • pediatrics

ASJC Scopus subject areas

  • Transplantation
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Mahle, W. T., Tresler, M. A., Edens, R. E., Rusconi, P., George, J. F., Naftel, D. C., & Shaddy, R. E. (2011). Allosensitization and outcomes in pediatric heart transplantation. Journal of Heart and Lung Transplantation, 30(11), 1221-1227. https://doi.org/10.1016/j.healun.2011.06.005