Allograft rejection of small bowel transplantation in pigs

Seigo Nishida, Teruo Komokata, Seiji Ogata, Akira Ikoma, Nobuo Hamada, Hitoshi Matsumoto, Takashi Ushijima, Koki Tanaka, Hiroki Yoshida, Akira Taira

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Small bowel allograft rejection in large animals has yet to be well defined. There are no specific early signs of graft rejection. The present experiments were undertaken to compare acute small bowel allograft rejection in pigs with and without FK506 and also to examine the usefulness of mucosal biopsies. Thirty-six outbred Large-White pigs were divided into (1) group 1 (n = 9): nonimmunosuppressed recipients; (2) group 2 (n = 8): FK506- immunosuppressed recipients; (3) group 3 (n = 2): autotransplant controls; and (4) donors (n = 17). Orthotopic small bowel transplantations were performed with Thiry-Vella loops for daily biopsies. The survival rate of group 2 was significantly longer than that of group 1 (P < 0.05). One best survivor in group 2 was killed at postoperative day (POD) 365. Treatment by FK506 prevented rejection, but most of the pigs died of pneumonia. In group 1, rejection began on POD 3 and progressed to severe rejection rapidly within 7 days. In group 2, rejection began from POD 6 to POD 8, but either remained mild or spontaneously improved. The differences in the routine laboratory data and the tumor necrosis factor-α level were not evident between the groups. Histological studies of repeated graft biopsies are thus considered to be essential for detecting signs of graft rejection.

Original languageEnglish (US)
Pages (from-to)1138-1145
Number of pages8
JournalSurgery Today
Volume28
Issue number11
DOIs
StatePublished - 1998

Keywords

  • Allograft rejection
  • Mucosal biopsy
  • Pig
  • Small bowel transplantation

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Nishida, S., Komokata, T., Ogata, S., Ikoma, A., Hamada, N., Matsumoto, H., Ushijima, T., Tanaka, K., Yoshida, H., & Taira, A. (1998). Allograft rejection of small bowel transplantation in pigs. Surgery Today, 28(11), 1138-1145. https://doi.org/10.1007/s005950050301