Allogeneic tumor-cell-based vaccines secreting endoplasmic reticulum chaperone gp96

Eckhard R. Podack, Luis E. Raez

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Heat-shock proteins are chaperones for proteins including tumor antigens. Heat-shock protein gp96, also known as glucose-regulated protein grp94, is the primary chaperone of the endoplasmic reticulum and a natural adjuvant for priming the innate and adaptive immune system. By transferring tumor cells with a genetically modified secretory form of gp96, the tumor cells are transformed into vaccine cells. Gp96 vaccines in murine studies trigger robust innate and antigen-specific cellular immune responses and cause tumor rejection followed by long-lasting tumor immunity. The authors briefly review here the generation of cytotoxic T lymphocyte responses by gp96 and the most up to date clinical data in the use of gp96-based cancer vaccines.

Original languageEnglish (US)
Pages (from-to)1679-1688
Number of pages10
JournalExpert Opinion on Biological Therapy
Volume7
Issue number11
DOIs
StatePublished - Nov 1 2007

Keywords

  • Cancer vaccines
  • CD8 CTL
  • Dendritic cells
  • Heat-shock proteins
  • Hspgp96
  • Immunotherapy
  • Innate immunity
  • NK cells
  • Non-immunogenic tumors

ASJC Scopus subject areas

  • Pharmacology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics
  • Immunology

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