Allogeneic bone marrow supports human islet β cell survival and function over six months

Lu Guang Luo, Evangelos Badiavas, John ZQ Luo, Abby Maizel

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

In this study, we have established a new strategy increasing human islet longevity utilizing allogeneic whole bone marrow (BM) co-cultured with human islets. The cultured islets' function and survival have been evaluated by analysis of insulin secretion in response to high-glucose-challenge, morphological evaluation of cell growth. Human islet only culture failed to reveal evidence of long term survival, growth or function in terms of insulin release or insulin response to glucose challenge. These results indicate that BM increases islet survival and function with the eventual formation of pancreatic endocrine tissue capable of sustaining β cell fuction.

Original languageEnglish (US)
Pages (from-to)859-864
Number of pages6
JournalBiochemical and biophysical research communications
Volume361
Issue number4
DOIs
StatePublished - Oct 5 2007
Externally publishedYes

Keywords

  • Allogeneic bone marrow
  • Diabetes
  • Function
  • Growth
  • Human islet
  • Insulin
  • Survival

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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