Allergy increases susceptibility to otitis media with effusion in a rat model

Robert F. Labadie, Brian S. Jewett, Craig F. Hart, Jiri Prazma, Harold C. Pillsbury

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To investigate the possible relationship between allergy and otitis media with effusion (OME), we investigated the hypothesis that allergen presentation to the middle ear causes functional disruption of the eustachian tube predisposing to the development of OME. Thirteen of 19 Brown-Norway rats were sensitized to ovalbumin, and the remaining 6 served as nonallergic controls. To mimic subclinical exposure to allergen, we transtympanically injected ovalbumin at a dose (0.01 mg) that produced no changes detectable by otologic examination. Next, both allergic and nonallergic rats were exposed to transtympanic injection of either low-dose (10 μg/mL) or high-dose (100 μg/mL) lipopolysaccharide to simulate bacterial exposure. The allergic rats were found to have larger middle ear effusions when exposed to high-dose lipopolysaccharide as compared with the nonallergic controls. This response could be inhibited by diphenhydramine. We conclude that allergen presentation to the middle ear of allergic rats causes eustachian tube dysfunction predisposing to OME.

Original languageEnglish
Pages (from-to)687-692
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Volume121
Issue number6
DOIs
StatePublished - Dec 23 1999
Externally publishedYes

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Otitis Media with Effusion
Hypersensitivity
Allergens
Eustachian Tube
Ovalbumin
Middle Ear
Lipopolysaccharides
Diphenhydramine
Injections

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Allergy increases susceptibility to otitis media with effusion in a rat model. / Labadie, Robert F.; Jewett, Brian S.; Hart, Craig F.; Prazma, Jiri; Pillsbury, Harold C.

In: Otolaryngology - Head and Neck Surgery, Vol. 121, No. 6, 23.12.1999, p. 687-692.

Research output: Contribution to journalArticle

Labadie, Robert F. ; Jewett, Brian S. ; Hart, Craig F. ; Prazma, Jiri ; Pillsbury, Harold C. / Allergy increases susceptibility to otitis media with effusion in a rat model. In: Otolaryngology - Head and Neck Surgery. 1999 ; Vol. 121, No. 6. pp. 687-692.
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