Allelic differences in the brain-derived neurotrophic factor val66met polymorphism in late-life depression

Warren D. Taylor, Stephan L Zuchner, Douglas R. Mcquoid, David C. Steffens, Marcy C. Speer, K. Ranga R Krishnan

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

OBJECTIVE: The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with cognitive and neuroimaging changes. The authors examined the relationship between this polymorphism and depression in an elderly sample, hypothesizing that the Met66 allele would be associated with late-life depression. METHODS: A total of 245 elderly depressed white subjects and 94 elderly comparison white subjects completed clinical assessments and provided a blood sample for genotyping. Subjects were dichotomized as either homozygous for the Val66 allele or Met66 allele carriers. Gene frequencies were compared between groups, with separate analyses examining for differences in gene frequencies based on age of depression onset, family history, and depression history. Logistic regression models examined the relationship between genotype and depression after controlling for age, sex, and race. RESULTS: Depressed subjects were more likely to be Met66 allele carriers than were comparison subjects (38.8% versus 24.4%; Χ 2 = 6.13, 1 df, p = 0.0133). This relationship remained significant after controlling for covariates (Wald Χ 2 = 5.10, 1 df, p = 0.024; odds ratio: 1.92, 95% confidence interval: 1.09-3.38). There were no significant relationships between genotype and age of onset, number of episodes, or family history of depression. CONCLUSION: Met66 allele carriers have almost double the odds of having geriatric depression than do Val66 allele homozygotes. This polymorphism was unrelated to other clinical characteristics of depression in later life.

Original languageEnglish
Pages (from-to)850-857
Number of pages8
JournalAmerican Journal of Geriatric Psychiatry
Volume15
Issue number10
DOIs
StatePublished - Oct 1 2007
Externally publishedYes

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Brain-Derived Neurotrophic Factor
Depression
Alleles
Age of Onset
Gene Frequency
Logistic Models
Genotype
Homozygote
Neuroimaging
Geriatrics
Odds Ratio
Confidence Intervals
Genes

Keywords

  • depression
  • Gene frequency
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

Allelic differences in the brain-derived neurotrophic factor val66met polymorphism in late-life depression. / Taylor, Warren D.; Zuchner, Stephan L; Mcquoid, Douglas R.; Steffens, David C.; Speer, Marcy C.; Krishnan, K. Ranga R.

In: American Journal of Geriatric Psychiatry, Vol. 15, No. 10, 01.10.2007, p. 850-857.

Research output: Contribution to journalArticle

Taylor, Warren D. ; Zuchner, Stephan L ; Mcquoid, Douglas R. ; Steffens, David C. ; Speer, Marcy C. ; Krishnan, K. Ranga R. / Allelic differences in the brain-derived neurotrophic factor val66met polymorphism in late-life depression. In: American Journal of Geriatric Psychiatry. 2007 ; Vol. 15, No. 10. pp. 850-857.
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