Allele Polymorphism of a New Pentanucleotide STR Marker Located to an Intron of the Tumor Suppressor Gene ING1

T. A. Borodina, D. V. Ivanov, E. K. Khusnutdinova, V. A. Spitsyn, A. V. Baranova, N. K. Yankovsky

Research output: Contribution to journalArticle

Abstract

Using polymerase chain reaction (PCR) DNA samples of unrelated subjects from the Volga-Ural region of Russia were examined to study allele polymorphism of the pentanucleotide repeat (TTGTG)g localized to an intron of the tumor suppressor gene ING1. STR marker was registered in the EMBL database with the accession number AJ277387. In a sample of 119 individuals, three pentanucleotide alleles consisting of seven, eight, and nine repeated monomers were revealed. The allele frequencies were 0.24, 0.74, and 0.02, respectively. Heterozygosity was 0.45. On the basis of these data, the repeat can be regarded as a polymorphic STR marker for the ING1 gene and used in population and clinical studies.

Original languageEnglish (US)
Pages (from-to)102-104
Number of pages3
JournalRussian Journal of Genetics
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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