Alcohol use in donors is a protective factor on recipients' outcome after heart transplantation

David De La Zerda, Oved Cohen, Ramin E. Beygui, John Kobashigawa, Diana Hekmat, Hillel Laks

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVE. The outcome of heart transplantation is highly influenced by good donor selection. Because a history of alcoholism is prevalent among potential heart donors, we sought to explore the effect of alcohol use in donors on the outcome of heart transplantation in the recipient. METHOD. A total of 437 consecutive patients underwent heart transplantation from January 2002 through September 2005. Patients' files were retrospectively studied. Mean follow-up period was 3.14±1.9 years (range, 3 days to 6.5 yrs). The cohort was divided into two subgroups. The alcoholic donor group (ADG) included 98 of 421 patients and the nonalcoholic donor group (NADG) included 323 of 421 patients. Mean age was 35.3±11.4 yrs (range, 18-66) for the ADG and 33±12.2 yrs (range, 18-62) for the NADG. RESULTS. Mortality among the ADG was 7 of 98 (7.1%) and for NADG was 55 of 323 (17.1%) (P=0.015). The mean interval time between transplant and mortality was, for ADG, 27.7±20.6 months (range, 0.07-51) and for NADG, 16.4±19.6 months (range, 0.14-73) (P=0.031). Survival rate was significantly higher among the ADG at 72.8±1.9 months compared with NADG at 66.2±1.5 months (P=0.019). Overall rejection rate was 22 of 421 (5.2%); rejection rate was 17 of 323 (5.2%) in NADG and 5 of 98 (5.1%) in ADG. Rejection free survival was 74.6±0.85 with no significant difference between the two groups (P=0.85). CONCLUSION. The chronic alcoholism of donors was found to be a protective factor regarding the outcome after heart transplantation. Significant differences were found in mortality rate and survival after heart transplantation between the ADG and NADG. These data support the fact that it is safe to use donors' hearts regardless of a history of alcoholism.

Original languageEnglish (US)
Pages (from-to)1214-1218
Number of pages5
JournalTransplantation
Volume83
Issue number9
DOIs
StatePublished - May 2007
Externally publishedYes

Fingerprint

Heart Transplantation
Alcohols
Tissue Donors
Alcoholics
Alcoholism
Protective Factors
Mortality
Donor Selection
Survival

Keywords

  • Alcoholic donor group
  • Chronic alcohol users
  • Heart transplantation

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Alcohol use in donors is a protective factor on recipients' outcome after heart transplantation. / De La Zerda, David; Cohen, Oved; Beygui, Ramin E.; Kobashigawa, John; Hekmat, Diana; Laks, Hillel.

In: Transplantation, Vol. 83, No. 9, 05.2007, p. 1214-1218.

Research output: Contribution to journalArticle

De La Zerda, David ; Cohen, Oved ; Beygui, Ramin E. ; Kobashigawa, John ; Hekmat, Diana ; Laks, Hillel. / Alcohol use in donors is a protective factor on recipients' outcome after heart transplantation. In: Transplantation. 2007 ; Vol. 83, No. 9. pp. 1214-1218.
@article{8a712d57a89642c8b4dc825679400495,
title = "Alcohol use in donors is a protective factor on recipients' outcome after heart transplantation",
abstract = "OBJECTIVE. The outcome of heart transplantation is highly influenced by good donor selection. Because a history of alcoholism is prevalent among potential heart donors, we sought to explore the effect of alcohol use in donors on the outcome of heart transplantation in the recipient. METHOD. A total of 437 consecutive patients underwent heart transplantation from January 2002 through September 2005. Patients' files were retrospectively studied. Mean follow-up period was 3.14±1.9 years (range, 3 days to 6.5 yrs). The cohort was divided into two subgroups. The alcoholic donor group (ADG) included 98 of 421 patients and the nonalcoholic donor group (NADG) included 323 of 421 patients. Mean age was 35.3±11.4 yrs (range, 18-66) for the ADG and 33±12.2 yrs (range, 18-62) for the NADG. RESULTS. Mortality among the ADG was 7 of 98 (7.1{\%}) and for NADG was 55 of 323 (17.1{\%}) (P=0.015). The mean interval time between transplant and mortality was, for ADG, 27.7±20.6 months (range, 0.07-51) and for NADG, 16.4±19.6 months (range, 0.14-73) (P=0.031). Survival rate was significantly higher among the ADG at 72.8±1.9 months compared with NADG at 66.2±1.5 months (P=0.019). Overall rejection rate was 22 of 421 (5.2{\%}); rejection rate was 17 of 323 (5.2{\%}) in NADG and 5 of 98 (5.1{\%}) in ADG. Rejection free survival was 74.6±0.85 with no significant difference between the two groups (P=0.85). CONCLUSION. The chronic alcoholism of donors was found to be a protective factor regarding the outcome after heart transplantation. Significant differences were found in mortality rate and survival after heart transplantation between the ADG and NADG. These data support the fact that it is safe to use donors' hearts regardless of a history of alcoholism.",
keywords = "Alcoholic donor group, Chronic alcohol users, Heart transplantation",
author = "{De La Zerda}, David and Oved Cohen and Beygui, {Ramin E.} and John Kobashigawa and Diana Hekmat and Hillel Laks",
year = "2007",
month = "5",
doi = "10.1097/01.tp.0000261713.24244.ea",
language = "English (US)",
volume = "83",
pages = "1214--1218",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Alcohol use in donors is a protective factor on recipients' outcome after heart transplantation

AU - De La Zerda, David

AU - Cohen, Oved

AU - Beygui, Ramin E.

AU - Kobashigawa, John

AU - Hekmat, Diana

AU - Laks, Hillel

PY - 2007/5

Y1 - 2007/5

N2 - OBJECTIVE. The outcome of heart transplantation is highly influenced by good donor selection. Because a history of alcoholism is prevalent among potential heart donors, we sought to explore the effect of alcohol use in donors on the outcome of heart transplantation in the recipient. METHOD. A total of 437 consecutive patients underwent heart transplantation from January 2002 through September 2005. Patients' files were retrospectively studied. Mean follow-up period was 3.14±1.9 years (range, 3 days to 6.5 yrs). The cohort was divided into two subgroups. The alcoholic donor group (ADG) included 98 of 421 patients and the nonalcoholic donor group (NADG) included 323 of 421 patients. Mean age was 35.3±11.4 yrs (range, 18-66) for the ADG and 33±12.2 yrs (range, 18-62) for the NADG. RESULTS. Mortality among the ADG was 7 of 98 (7.1%) and for NADG was 55 of 323 (17.1%) (P=0.015). The mean interval time between transplant and mortality was, for ADG, 27.7±20.6 months (range, 0.07-51) and for NADG, 16.4±19.6 months (range, 0.14-73) (P=0.031). Survival rate was significantly higher among the ADG at 72.8±1.9 months compared with NADG at 66.2±1.5 months (P=0.019). Overall rejection rate was 22 of 421 (5.2%); rejection rate was 17 of 323 (5.2%) in NADG and 5 of 98 (5.1%) in ADG. Rejection free survival was 74.6±0.85 with no significant difference between the two groups (P=0.85). CONCLUSION. The chronic alcoholism of donors was found to be a protective factor regarding the outcome after heart transplantation. Significant differences were found in mortality rate and survival after heart transplantation between the ADG and NADG. These data support the fact that it is safe to use donors' hearts regardless of a history of alcoholism.

AB - OBJECTIVE. The outcome of heart transplantation is highly influenced by good donor selection. Because a history of alcoholism is prevalent among potential heart donors, we sought to explore the effect of alcohol use in donors on the outcome of heart transplantation in the recipient. METHOD. A total of 437 consecutive patients underwent heart transplantation from January 2002 through September 2005. Patients' files were retrospectively studied. Mean follow-up period was 3.14±1.9 years (range, 3 days to 6.5 yrs). The cohort was divided into two subgroups. The alcoholic donor group (ADG) included 98 of 421 patients and the nonalcoholic donor group (NADG) included 323 of 421 patients. Mean age was 35.3±11.4 yrs (range, 18-66) for the ADG and 33±12.2 yrs (range, 18-62) for the NADG. RESULTS. Mortality among the ADG was 7 of 98 (7.1%) and for NADG was 55 of 323 (17.1%) (P=0.015). The mean interval time between transplant and mortality was, for ADG, 27.7±20.6 months (range, 0.07-51) and for NADG, 16.4±19.6 months (range, 0.14-73) (P=0.031). Survival rate was significantly higher among the ADG at 72.8±1.9 months compared with NADG at 66.2±1.5 months (P=0.019). Overall rejection rate was 22 of 421 (5.2%); rejection rate was 17 of 323 (5.2%) in NADG and 5 of 98 (5.1%) in ADG. Rejection free survival was 74.6±0.85 with no significant difference between the two groups (P=0.85). CONCLUSION. The chronic alcoholism of donors was found to be a protective factor regarding the outcome after heart transplantation. Significant differences were found in mortality rate and survival after heart transplantation between the ADG and NADG. These data support the fact that it is safe to use donors' hearts regardless of a history of alcoholism.

KW - Alcoholic donor group

KW - Chronic alcohol users

KW - Heart transplantation

UR - http://www.scopus.com/inward/record.url?scp=34248392641&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248392641&partnerID=8YFLogxK

U2 - 10.1097/01.tp.0000261713.24244.ea

DO - 10.1097/01.tp.0000261713.24244.ea

M3 - Article

VL - 83

SP - 1214

EP - 1218

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 9

ER -