Alcohol use at time of injury and survival following traumatic brain injury: Results from the national trauma data bank

Chiung M. Chen, Hsiao Ye Yi, Young Hee Yoon, Chuanhui Dong

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objective: Premised on biological evidence from animal research, recent clinical studies have, for the most part, concluded that elevated blood alcohol concentration levels are independently associated with higher survival or decreased mortality in patients with moderate to severe traumatic brain injury (TBI). This study aims to provide some counterevidence to this claim and to further future investigations. Method: Incident data were drawn from the largest U.S. trauma registry, the National Trauma Data Bank, for emergency department admission years 2002-2006. TBI was identified according to the National Trauma Data Bank's definition using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM), codes. To eliminate confounding, the exact matching method was used to match alcohol-positive with alcohol-negative incidents on sex, age, race/ethnicity, and facility. Logistic regression compared in-hospital mortality between 44,043 alcohol-positive and 59,817 matched alcohol-negative TBI incidents, with and without causes and intents of TBI and Injury Severity Score as covariates. A sensitivity analysis was performed within a subsample of isolated moderate to severe TBI incidents. Results: Alcohol use at the time of injury was found to be significantly associated with an increased risk for TBI. Including varied causes and intents of TBI and Injury Severity Score as potential confounders in the regression model explained away the statistical significance of the seemingly protective effect of alcohol against TBI mortality for all TBIs and for isolated moderate to severe TBIs. Conclusions: The null finding shows that the purported reduction in TBI mortality attributed to positive blood alcohol likely is attributable to residual confounding. Accordingly, the risk of TBI associated with alcohol use should not be overlooked.

Original languageEnglish
Pages (from-to)531-541
Number of pages11
JournalJournal of Studies on Alcohol and Drugs
Volume73
Issue number4
StatePublished - Jul 1 2012
Externally publishedYes

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data bank
trauma
Brain
brain
alcohol
Alcohols
Databases
Survival
Wounds and Injuries
incident
mortality
Injury Severity Score
International Classification of Diseases
Mortality
Blood
time
Traumatic Brain Injury
regression
cause
statistical significance

ASJC Scopus subject areas

  • Health(social science)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Alcohol use at time of injury and survival following traumatic brain injury : Results from the national trauma data bank. / Chen, Chiung M.; Yi, Hsiao Ye; Yoon, Young Hee; Dong, Chuanhui.

In: Journal of Studies on Alcohol and Drugs, Vol. 73, No. 4, 01.07.2012, p. 531-541.

Research output: Contribution to journalArticle

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