Alcohol consumption and common carotid intima-media thickness: The USE-IMT study

Annie R. Britton, Diederick E. Grobbee, Hester M. den Ruijter, Todd J. Anderson, Moise Desvarieux, Gunnar Engström, Greg W. Evans, Bo Hedblad, Jussi Kauhanen, Sudhir Kurl, Eva M. Lonn, Ellisiv B. Mathiesen, Joseph F. Polak, Jacqueline F. Price, Christopher M. Rembold, Maria Rosvall, Tatjana Rundek, Jukka T. Salonen, Coen Stehouwer, Tomi Pekka TuomainenMichiel L. Bots

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims: Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population. Methods: Individual participant data from eight cohorts, involving 37,494 individuals from the USE-IMT collaboration were used. Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) with alcohol consumption. Results: The mean age was 57.9 years (SD 8.6) and the mean CIMT was 0.75 mm (SD 0.177). About, 40.5% reported no alcohol consumed, and among those who drank, mean consumption was 13.3 g per day (SD 16.4). Those consuming no alcohol or a very small amount (<5 g per day) had significantly lower common CIMT values than those consuming >10 g per day, after adjusting for a range of confounding factors. Conclusion: In this large CIMT consortium, we did not find evidence to support a protective effect of alcohol on CIMT.

Original languageEnglish (US)
Pages (from-to)483-486
Number of pages4
JournalAlcohol and Alcoholism
Volume52
Issue number4
DOIs
StatePublished - Jul 1 2017

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Carotid Intima-Media Thickness
Alcohol Drinking
Alcohols
Linear Models
Drinking
Atherosclerosis
Linear regression
Light
Population

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Medicine(all)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Britton, A. R., Grobbee, D. E., den Ruijter, H. M., Anderson, T. J., Desvarieux, M., Engström, G., ... Bots, M. L. (2017). Alcohol consumption and common carotid intima-media thickness: The USE-IMT study. Alcohol and Alcoholism, 52(4), 483-486. https://doi.org/10.1093/alcalc/agx028

Alcohol consumption and common carotid intima-media thickness : The USE-IMT study. / Britton, Annie R.; Grobbee, Diederick E.; den Ruijter, Hester M.; Anderson, Todd J.; Desvarieux, Moise; Engström, Gunnar; Evans, Greg W.; Hedblad, Bo; Kauhanen, Jussi; Kurl, Sudhir; Lonn, Eva M.; Mathiesen, Ellisiv B.; Polak, Joseph F.; Price, Jacqueline F.; Rembold, Christopher M.; Rosvall, Maria; Rundek, Tatjana; Salonen, Jukka T.; Stehouwer, Coen; Tuomainen, Tomi Pekka; Bots, Michiel L.

In: Alcohol and Alcoholism, Vol. 52, No. 4, 01.07.2017, p. 483-486.

Research output: Contribution to journalArticle

Britton, AR, Grobbee, DE, den Ruijter, HM, Anderson, TJ, Desvarieux, M, Engström, G, Evans, GW, Hedblad, B, Kauhanen, J, Kurl, S, Lonn, EM, Mathiesen, EB, Polak, JF, Price, JF, Rembold, CM, Rosvall, M, Rundek, T, Salonen, JT, Stehouwer, C, Tuomainen, TP & Bots, ML 2017, 'Alcohol consumption and common carotid intima-media thickness: The USE-IMT study', Alcohol and Alcoholism, vol. 52, no. 4, pp. 483-486. https://doi.org/10.1093/alcalc/agx028
Britton AR, Grobbee DE, den Ruijter HM, Anderson TJ, Desvarieux M, Engström G et al. Alcohol consumption and common carotid intima-media thickness: The USE-IMT study. Alcohol and Alcoholism. 2017 Jul 1;52(4):483-486. https://doi.org/10.1093/alcalc/agx028
Britton, Annie R. ; Grobbee, Diederick E. ; den Ruijter, Hester M. ; Anderson, Todd J. ; Desvarieux, Moise ; Engström, Gunnar ; Evans, Greg W. ; Hedblad, Bo ; Kauhanen, Jussi ; Kurl, Sudhir ; Lonn, Eva M. ; Mathiesen, Ellisiv B. ; Polak, Joseph F. ; Price, Jacqueline F. ; Rembold, Christopher M. ; Rosvall, Maria ; Rundek, Tatjana ; Salonen, Jukka T. ; Stehouwer, Coen ; Tuomainen, Tomi Pekka ; Bots, Michiel L. / Alcohol consumption and common carotid intima-media thickness : The USE-IMT study. In: Alcohol and Alcoholism. 2017 ; Vol. 52, No. 4. pp. 483-486.
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AU - Britton, Annie R.

AU - Grobbee, Diederick E.

AU - den Ruijter, Hester M.

AU - Anderson, Todd J.

AU - Desvarieux, Moise

AU - Engström, Gunnar

AU - Evans, Greg W.

AU - Hedblad, Bo

AU - Kauhanen, Jussi

AU - Kurl, Sudhir

AU - Lonn, Eva M.

AU - Mathiesen, Ellisiv B.

AU - Polak, Joseph F.

AU - Price, Jacqueline F.

AU - Rembold, Christopher M.

AU - Rosvall, Maria

AU - Rundek, Tatjana

AU - Salonen, Jukka T.

AU - Stehouwer, Coen

AU - Tuomainen, Tomi Pekka

AU - Bots, Michiel L.

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N2 - Aims: Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population. Methods: Individual participant data from eight cohorts, involving 37,494 individuals from the USE-IMT collaboration were used. Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) with alcohol consumption. Results: The mean age was 57.9 years (SD 8.6) and the mean CIMT was 0.75 mm (SD 0.177). About, 40.5% reported no alcohol consumed, and among those who drank, mean consumption was 13.3 g per day (SD 16.4). Those consuming no alcohol or a very small amount (<5 g per day) had significantly lower common CIMT values than those consuming >10 g per day, after adjusting for a range of confounding factors. Conclusion: In this large CIMT consortium, we did not find evidence to support a protective effect of alcohol on CIMT.

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