Alcohol consumption and atherosclerotic burden in the proximal thoracic aorta

Shun Kohsaka, Zhezhen Jin, Tatjana Rundek, Shunichi Homma, Ralph L Sacco, Marco R. Di Tullio

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: The relationship between alcohol consumption and ischemic stroke or aortic atherosclerosis is unclear, but a protective effect of moderate consumption on stroke risk has been suggested. We conducted a cross-sectional analysis in a population-based sample to evaluate the possible association between alcohol consumption and aortic atherosclerotic plaque (AAP), which is associated with increased stroke risk. Methods: As part of the NINDS-funded Aortic Plaques and Risk of Ischemic Stroke (APRIS) study, 464 subjects over the age of 55 were studied (mean age 69.1 ± 9.0 with 251 males and 213 females), including 255 patients with first ischemic stroke and 209 stroke-free controls. Transesophageal echocardiogram was performed for the detection of AAP. Alcohol consumption was measured in number of drinks per week during the previous year using a standardized questionnaire, and categorized as: (1) none or minimal (<1 drink per month); (2) light to moderate (between 1 drink per month and 2 drinks daily); and (3) heavy (>2 daily). Multivariate conditional logistic regression analysis was used to calculate the odds ratios (ORs) and 95% confidence interval (CI) for alcohol consumption and AAP after adjustment for the potential confounding risk factors (age, sex, hypertension, diabetes, dyslipidemia, and cigarette smoking). Results: Overall, AAP was detected in 326 subjects (70.4%), and 174 subjects (37.6%) had AAP ≥ 4. mm, which carry higher stroke risk. No or minimal alcohol consumption was present in 241 subjects (53.2%), and 177 subjects (39.0%) had light to moderate consumption. Prevalence of light to moderate alcohol consumption was significantly lower in stroke patients than in controls (35.5% vs. 60.3%, p< 0.001) and in subjects who had AAP compared with those without it (41.6% vs. 58.8%, p= 0.008). After adjusting for significant predictors of atherosclerosis, alcohol consumption of any degree was inversely associated with AAP (OR 0.61; 95% CI 0.37-0.98, p= 0.042). The significance of the association was borderline for AAP ≥ 4. mm (OR 0.64, 95% CI 0.41-1.00, p= 0.054). In the dose-response analysis, only light to moderate alcohol consumption was significantly associated with a lower risk of having any AAP (adjusted OR 0.45; 95% CI 0.29-0.68, p< 0.001) or AAP ≥ 4. mm (adjusted OR 0.51; 95% CI 0.34-0.77, p= 0.001). Conclusions: Our data indicate that light to moderate alcohol consumption is associated with lower atherosclerotic burden in the proximal aortic arch. This observation may explain at least in part the lower risk of ischemic stroke observed in moderate alcohol consumers.

Original languageEnglish
Pages (from-to)794-798
Number of pages5
JournalAtherosclerosis
Volume219
Issue number2
DOIs
StatePublished - Dec 1 2011

Fingerprint

Atherosclerotic Plaques
Thoracic Aorta
Alcohol Drinking
Stroke
Odds Ratio
Confidence Intervals
Light
Atherosclerosis
National Institute of Neurological Disorders and Stroke
Dyslipidemias
Cross-Sectional Studies
Logistic Models
Smoking
Regression Analysis
Alcohols
Hypertension

Keywords

  • Alcohol drinking
  • Aorta
  • Atherosclerosis
  • Risk factors
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Alcohol consumption and atherosclerotic burden in the proximal thoracic aorta. / Kohsaka, Shun; Jin, Zhezhen; Rundek, Tatjana; Homma, Shunichi; Sacco, Ralph L; Di Tullio, Marco R.

In: Atherosclerosis, Vol. 219, No. 2, 01.12.2011, p. 794-798.

Research output: Contribution to journalArticle

Kohsaka, Shun ; Jin, Zhezhen ; Rundek, Tatjana ; Homma, Shunichi ; Sacco, Ralph L ; Di Tullio, Marco R. / Alcohol consumption and atherosclerotic burden in the proximal thoracic aorta. In: Atherosclerosis. 2011 ; Vol. 219, No. 2. pp. 794-798.
@article{ac297d1271be4552b51314b3929b023a,
title = "Alcohol consumption and atherosclerotic burden in the proximal thoracic aorta",
abstract = "Background: The relationship between alcohol consumption and ischemic stroke or aortic atherosclerosis is unclear, but a protective effect of moderate consumption on stroke risk has been suggested. We conducted a cross-sectional analysis in a population-based sample to evaluate the possible association between alcohol consumption and aortic atherosclerotic plaque (AAP), which is associated with increased stroke risk. Methods: As part of the NINDS-funded Aortic Plaques and Risk of Ischemic Stroke (APRIS) study, 464 subjects over the age of 55 were studied (mean age 69.1 ± 9.0 with 251 males and 213 females), including 255 patients with first ischemic stroke and 209 stroke-free controls. Transesophageal echocardiogram was performed for the detection of AAP. Alcohol consumption was measured in number of drinks per week during the previous year using a standardized questionnaire, and categorized as: (1) none or minimal (<1 drink per month); (2) light to moderate (between 1 drink per month and 2 drinks daily); and (3) heavy (>2 daily). Multivariate conditional logistic regression analysis was used to calculate the odds ratios (ORs) and 95{\%} confidence interval (CI) for alcohol consumption and AAP after adjustment for the potential confounding risk factors (age, sex, hypertension, diabetes, dyslipidemia, and cigarette smoking). Results: Overall, AAP was detected in 326 subjects (70.4{\%}), and 174 subjects (37.6{\%}) had AAP ≥ 4. mm, which carry higher stroke risk. No or minimal alcohol consumption was present in 241 subjects (53.2{\%}), and 177 subjects (39.0{\%}) had light to moderate consumption. Prevalence of light to moderate alcohol consumption was significantly lower in stroke patients than in controls (35.5{\%} vs. 60.3{\%}, p< 0.001) and in subjects who had AAP compared with those without it (41.6{\%} vs. 58.8{\%}, p= 0.008). After adjusting for significant predictors of atherosclerosis, alcohol consumption of any degree was inversely associated with AAP (OR 0.61; 95{\%} CI 0.37-0.98, p= 0.042). The significance of the association was borderline for AAP ≥ 4. mm (OR 0.64, 95{\%} CI 0.41-1.00, p= 0.054). In the dose-response analysis, only light to moderate alcohol consumption was significantly associated with a lower risk of having any AAP (adjusted OR 0.45; 95{\%} CI 0.29-0.68, p< 0.001) or AAP ≥ 4. mm (adjusted OR 0.51; 95{\%} CI 0.34-0.77, p= 0.001). Conclusions: Our data indicate that light to moderate alcohol consumption is associated with lower atherosclerotic burden in the proximal aortic arch. This observation may explain at least in part the lower risk of ischemic stroke observed in moderate alcohol consumers.",
keywords = "Alcohol drinking, Aorta, Atherosclerosis, Risk factors, Stroke",
author = "Shun Kohsaka and Zhezhen Jin and Tatjana Rundek and Shunichi Homma and Sacco, {Ralph L} and {Di Tullio}, {Marco R.}",
year = "2011",
month = "12",
day = "1",
doi = "10.1016/j.atherosclerosis.2011.07.129",
language = "English",
volume = "219",
pages = "794--798",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Alcohol consumption and atherosclerotic burden in the proximal thoracic aorta

AU - Kohsaka, Shun

AU - Jin, Zhezhen

AU - Rundek, Tatjana

AU - Homma, Shunichi

AU - Sacco, Ralph L

AU - Di Tullio, Marco R.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Background: The relationship between alcohol consumption and ischemic stroke or aortic atherosclerosis is unclear, but a protective effect of moderate consumption on stroke risk has been suggested. We conducted a cross-sectional analysis in a population-based sample to evaluate the possible association between alcohol consumption and aortic atherosclerotic plaque (AAP), which is associated with increased stroke risk. Methods: As part of the NINDS-funded Aortic Plaques and Risk of Ischemic Stroke (APRIS) study, 464 subjects over the age of 55 were studied (mean age 69.1 ± 9.0 with 251 males and 213 females), including 255 patients with first ischemic stroke and 209 stroke-free controls. Transesophageal echocardiogram was performed for the detection of AAP. Alcohol consumption was measured in number of drinks per week during the previous year using a standardized questionnaire, and categorized as: (1) none or minimal (<1 drink per month); (2) light to moderate (between 1 drink per month and 2 drinks daily); and (3) heavy (>2 daily). Multivariate conditional logistic regression analysis was used to calculate the odds ratios (ORs) and 95% confidence interval (CI) for alcohol consumption and AAP after adjustment for the potential confounding risk factors (age, sex, hypertension, diabetes, dyslipidemia, and cigarette smoking). Results: Overall, AAP was detected in 326 subjects (70.4%), and 174 subjects (37.6%) had AAP ≥ 4. mm, which carry higher stroke risk. No or minimal alcohol consumption was present in 241 subjects (53.2%), and 177 subjects (39.0%) had light to moderate consumption. Prevalence of light to moderate alcohol consumption was significantly lower in stroke patients than in controls (35.5% vs. 60.3%, p< 0.001) and in subjects who had AAP compared with those without it (41.6% vs. 58.8%, p= 0.008). After adjusting for significant predictors of atherosclerosis, alcohol consumption of any degree was inversely associated with AAP (OR 0.61; 95% CI 0.37-0.98, p= 0.042). The significance of the association was borderline for AAP ≥ 4. mm (OR 0.64, 95% CI 0.41-1.00, p= 0.054). In the dose-response analysis, only light to moderate alcohol consumption was significantly associated with a lower risk of having any AAP (adjusted OR 0.45; 95% CI 0.29-0.68, p< 0.001) or AAP ≥ 4. mm (adjusted OR 0.51; 95% CI 0.34-0.77, p= 0.001). Conclusions: Our data indicate that light to moderate alcohol consumption is associated with lower atherosclerotic burden in the proximal aortic arch. This observation may explain at least in part the lower risk of ischemic stroke observed in moderate alcohol consumers.

AB - Background: The relationship between alcohol consumption and ischemic stroke or aortic atherosclerosis is unclear, but a protective effect of moderate consumption on stroke risk has been suggested. We conducted a cross-sectional analysis in a population-based sample to evaluate the possible association between alcohol consumption and aortic atherosclerotic plaque (AAP), which is associated with increased stroke risk. Methods: As part of the NINDS-funded Aortic Plaques and Risk of Ischemic Stroke (APRIS) study, 464 subjects over the age of 55 were studied (mean age 69.1 ± 9.0 with 251 males and 213 females), including 255 patients with first ischemic stroke and 209 stroke-free controls. Transesophageal echocardiogram was performed for the detection of AAP. Alcohol consumption was measured in number of drinks per week during the previous year using a standardized questionnaire, and categorized as: (1) none or minimal (<1 drink per month); (2) light to moderate (between 1 drink per month and 2 drinks daily); and (3) heavy (>2 daily). Multivariate conditional logistic regression analysis was used to calculate the odds ratios (ORs) and 95% confidence interval (CI) for alcohol consumption and AAP after adjustment for the potential confounding risk factors (age, sex, hypertension, diabetes, dyslipidemia, and cigarette smoking). Results: Overall, AAP was detected in 326 subjects (70.4%), and 174 subjects (37.6%) had AAP ≥ 4. mm, which carry higher stroke risk. No or minimal alcohol consumption was present in 241 subjects (53.2%), and 177 subjects (39.0%) had light to moderate consumption. Prevalence of light to moderate alcohol consumption was significantly lower in stroke patients than in controls (35.5% vs. 60.3%, p< 0.001) and in subjects who had AAP compared with those without it (41.6% vs. 58.8%, p= 0.008). After adjusting for significant predictors of atherosclerosis, alcohol consumption of any degree was inversely associated with AAP (OR 0.61; 95% CI 0.37-0.98, p= 0.042). The significance of the association was borderline for AAP ≥ 4. mm (OR 0.64, 95% CI 0.41-1.00, p= 0.054). In the dose-response analysis, only light to moderate alcohol consumption was significantly associated with a lower risk of having any AAP (adjusted OR 0.45; 95% CI 0.29-0.68, p< 0.001) or AAP ≥ 4. mm (adjusted OR 0.51; 95% CI 0.34-0.77, p= 0.001). Conclusions: Our data indicate that light to moderate alcohol consumption is associated with lower atherosclerotic burden in the proximal aortic arch. This observation may explain at least in part the lower risk of ischemic stroke observed in moderate alcohol consumers.

KW - Alcohol drinking

KW - Aorta

KW - Atherosclerosis

KW - Risk factors

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=82955195428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82955195428&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2011.07.129

DO - 10.1016/j.atherosclerosis.2011.07.129

M3 - Article

C2 - 21885050

AN - SCOPUS:82955195428

VL - 219

SP - 794

EP - 798

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -