Albuminuria in recent-onset type 2 diabetes: The Strong Heart Study

Jay M Sosenko, Dongsheng Hu, Tom Welty, Barbara V. Howard, Elisa Lee, David C. Robbins

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

OBJECTIVE - It is not known how frequently abnormal albumin excretion occurs in the initial years after the onset of type 2 diabetes and to what extent its occurrence is related to the severity of diabetes. We have used a prospective cohort study to examine this. RESEARCH DESIGN AND METHODS - A total of 782 participants from the Strong Heart Study who had normal glucose tolerance and normal albumin excretion (albumin-to-creatinine ratio <30 mg albumin/g creatinine) at baseline were assessed for diabetes and abnormal albumin excretion at a follow-up visit (interval 3.91 ± 0.95 years, mean ± SD). Logistic regression models were used to examine the associations. RESULTS - Abnormal albumin excretion was detected in 52 (6.6%) and diabetes was determined to be present in 105 (13.4%) of the participants at the follow-up visit. In univariate analyses, abnormal albumin excretion was statistically significantly related to the baseline albumin-to-creatinine ratio, diastolic blood pressure, fasting insulin, and extent of American Indian heritage. Abnormal albumin excretion was much more prevalent in those with recent onset diabetes at the follow-up visit (18 vs. 5%, P < 0.001). In a logistic regression analysis, abnormal albumin excretion and diabetes remained strongly related (odds ratio 3.45, P < 0.001), and associations of abnormal albumin excretion with baseline albumin-to-creatinine ratio, blood pressure, and American Indian heritage also remained significant in a separate logistic regression analysis, including only those who developed diabetes. There was a strong association between abnormal albumin excretion and fasting glucose levels (<0.01) at the follow-up visit. CONCLUSIONS - These data suggest that an appreciable percentage of individuals develop abnormal albumin excretion within the first few years after the onset of type 2 diabetes. Also, the severity of diabetes at onset appears to be a key risk factor for the early development of abnormal albumin excretion.

Original languageEnglish
Pages (from-to)1078-1084
Number of pages7
JournalDiabetes Care
Volume25
Issue number6
DOIs
StatePublished - Jun 1 2002

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Albuminuria
Type 2 Diabetes Mellitus
Albumins
Creatinine
Logistic Models
North American Indians
Blood Pressure
Fasting
Regression Analysis
Glucose

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Sosenko, J. M., Hu, D., Welty, T., Howard, B. V., Lee, E., & Robbins, D. C. (2002). Albuminuria in recent-onset type 2 diabetes: The Strong Heart Study. Diabetes Care, 25(6), 1078-1084. https://doi.org/10.2337/diacare.25.6.1078

Albuminuria in recent-onset type 2 diabetes : The Strong Heart Study. / Sosenko, Jay M; Hu, Dongsheng; Welty, Tom; Howard, Barbara V.; Lee, Elisa; Robbins, David C.

In: Diabetes Care, Vol. 25, No. 6, 01.06.2002, p. 1078-1084.

Research output: Contribution to journalArticle

Sosenko, JM, Hu, D, Welty, T, Howard, BV, Lee, E & Robbins, DC 2002, 'Albuminuria in recent-onset type 2 diabetes: The Strong Heart Study', Diabetes Care, vol. 25, no. 6, pp. 1078-1084. https://doi.org/10.2337/diacare.25.6.1078
Sosenko, Jay M ; Hu, Dongsheng ; Welty, Tom ; Howard, Barbara V. ; Lee, Elisa ; Robbins, David C. / Albuminuria in recent-onset type 2 diabetes : The Strong Heart Study. In: Diabetes Care. 2002 ; Vol. 25, No. 6. pp. 1078-1084.
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AB - OBJECTIVE - It is not known how frequently abnormal albumin excretion occurs in the initial years after the onset of type 2 diabetes and to what extent its occurrence is related to the severity of diabetes. We have used a prospective cohort study to examine this. RESEARCH DESIGN AND METHODS - A total of 782 participants from the Strong Heart Study who had normal glucose tolerance and normal albumin excretion (albumin-to-creatinine ratio <30 mg albumin/g creatinine) at baseline were assessed for diabetes and abnormal albumin excretion at a follow-up visit (interval 3.91 ± 0.95 years, mean ± SD). Logistic regression models were used to examine the associations. RESULTS - Abnormal albumin excretion was detected in 52 (6.6%) and diabetes was determined to be present in 105 (13.4%) of the participants at the follow-up visit. In univariate analyses, abnormal albumin excretion was statistically significantly related to the baseline albumin-to-creatinine ratio, diastolic blood pressure, fasting insulin, and extent of American Indian heritage. Abnormal albumin excretion was much more prevalent in those with recent onset diabetes at the follow-up visit (18 vs. 5%, P < 0.001). In a logistic regression analysis, abnormal albumin excretion and diabetes remained strongly related (odds ratio 3.45, P < 0.001), and associations of abnormal albumin excretion with baseline albumin-to-creatinine ratio, blood pressure, and American Indian heritage also remained significant in a separate logistic regression analysis, including only those who developed diabetes. There was a strong association between abnormal albumin excretion and fasting glucose levels (<0.01) at the follow-up visit. CONCLUSIONS - These data suggest that an appreciable percentage of individuals develop abnormal albumin excretion within the first few years after the onset of type 2 diabetes. Also, the severity of diabetes at onset appears to be a key risk factor for the early development of abnormal albumin excretion.

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