Akinetic‐rigid syndrome in a 13‐year‐old girl with HIV‐related progressive multifocal leukoencephalopathy

Carlos Singer; Joseph R. Berger; Brian C. Bowen; Jocelyn H. Bruce; William J. Weiner

doi:10.1002/mds.870080120

Akinetic‐rigid syndrome in a 13‐year‐old girl with HIV‐related progressive multifocal leukoencephalopathy

Carlos Singer, Joseph R. Berger, Brian C. Bowen, Jocelyn H. Bruce, William J. Weiner

Neurology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A 13-year-old HIV-infected girl presented with a rapidly progressive akinetic-rigid syndrome. Cranial magnetic resonance imaging revealed bilateral centrum semiovale lesions extending into the basal ganglia. Detailed histopathological study of a biopsy specimen from the involved regions resulted in a diagnosis of progressive multifocal leukoencephalopathy (PML). This case illustrates that an akinetic-rigid syndrome may be a rare presentation of PML. HIV-related PML may have unusual radiological features. Brain biopsy may be necessary to confirm PML in cases associated with atypical clinical and radiological presentations.

Original language	English (US)
Pages (from-to)	113-116
Number of pages	4
Journal	Movement Disorders
Volume	8
Issue number	1
DOIs	https://doi.org/10.1002/mds.870080120
State	Published - 1993

Keywords

Acquired immunodeficiency syndrome
Akinetic‐rigid syndrome
Basal ganglia diseases
Bradykinesia
Magnetic resonance imaging
Parkinsonism
Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

Neurology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/mds.870080120

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abstract = "A 13-year-old HIV-infected girl presented with a rapidly progressive akinetic-rigid syndrome. Cranial magnetic resonance imaging revealed bilateral centrum semiovale lesions extending into the basal ganglia. Detailed histopathological study of a biopsy specimen from the involved regions resulted in a diagnosis of progressive multifocal leukoencephalopathy (PML). This case illustrates that an akinetic-rigid syndrome may be a rare presentation of PML. HIV-related PML may have unusual radiological features. Brain biopsy may be necessary to confirm PML in cases associated with atypical clinical and radiological presentations.",

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AU - Bruce, Jocelyn H.

AU - Weiner, William J.

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AB - A 13-year-old HIV-infected girl presented with a rapidly progressive akinetic-rigid syndrome. Cranial magnetic resonance imaging revealed bilateral centrum semiovale lesions extending into the basal ganglia. Detailed histopathological study of a biopsy specimen from the involved regions resulted in a diagnosis of progressive multifocal leukoencephalopathy (PML). This case illustrates that an akinetic-rigid syndrome may be a rare presentation of PML. HIV-related PML may have unusual radiological features. Brain biopsy may be necessary to confirm PML in cases associated with atypical clinical and radiological presentations.

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Akinetic‐rigid syndrome in a 13‐year‐old girl with HIV‐related progressive multifocal leukoencephalopathy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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