Abstract
A 13-year-old HIV-infected girl presented with a rapidly progressive akinetic-rigid syndrome. Cranial magnetic resonance imaging revealed bilateral centrum semiovale lesions extending into the basal ganglia. Detailed histopathological study of a biopsy specimen from the involved regions resulted in a diagnosis of progressive multifocal leukoencephalopathy (PML). This case illustrates that an akinetic-rigid syndrome may be a rare presentation of PML. HIV-related PML may have unusual radiological features. Brain biopsy may be necessary to confirm PML in cases associated with atypical clinical and radiological presentations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 113-116 |
| Number of pages | 4 |
| Journal | Movement Disorders |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1993 |
Keywords
- Acquired immunodeficiency syndrome
- Akinetic‐rigid syndrome
- Basal ganglia diseases
- Bradykinesia
- Magnetic resonance imaging
- Parkinsonism
- Progressive multifocal leukoencephalopathy
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
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Cite this
Singer, C., Berger, J. R., Bowen, B. C., Bruce, J. H., & Weiner, W. J. (1993). Akinetic‐rigid syndrome in a 13‐year‐old girl with HIV‐related progressive multifocal leukoencephalopathy. Movement Disorders, 8(1), 113-116. https://doi.org/10.1002/mds.870080120