Akinetic‐rigid syndrome in a 13‐year‐old girl with HIV‐related progressive multifocal leukoencephalopathy

Carlos Singer, Joseph R. Berger, Brian C. Bowen, Jocelyn H. Bruce, William J. Weiner

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


A 13-year-old HIV-infected girl presented with a rapidly progressive akinetic-rigid syndrome. Cranial magnetic resonance imaging revealed bilateral centrum semiovale lesions extending into the basal ganglia. Detailed histopathological study of a biopsy specimen from the involved regions resulted in a diagnosis of progressive multifocal leukoencephalopathy (PML). This case illustrates that an akinetic-rigid syndrome may be a rare presentation of PML. HIV-related PML may have unusual radiological features. Brain biopsy may be necessary to confirm PML in cases associated with atypical clinical and radiological presentations.

Original languageEnglish (US)
Pages (from-to)113-116
Number of pages4
JournalMovement Disorders
Issue number1
StatePublished - 1993


  • Acquired immunodeficiency syndrome
  • Akinetic‐rigid syndrome
  • Basal ganglia diseases
  • Bradykinesia
  • Magnetic resonance imaging
  • Parkinsonism
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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