Akinetic‐rigid syndrome in a 13‐year‐old girl with HIV‐related progressive multifocal leukoencephalopathy

Carlos Singer; Joseph R. Berger; Brian C. Bowen; Jocelyn H. Bruce; William J. Weiner

doi:10.1002/mds.870080120

Akinetic‐rigid syndrome in a 13‐year‐old girl with HIV‐related progressive multifocal leukoencephalopathy

Carlos Singer, Joseph R. Berger, Brian C. Bowen, Jocelyn H. Bruce, William J. Weiner

Neurology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A 13-year-old HIV-infected girl presented with a rapidly progressive akinetic-rigid syndrome. Cranial magnetic resonance imaging revealed bilateral centrum semiovale lesions extending into the basal ganglia. Detailed histopathological study of a biopsy specimen from the involved regions resulted in a diagnosis of progressive multifocal leukoencephalopathy (PML). This case illustrates that an akinetic-rigid syndrome may be a rare presentation of PML. HIV-related PML may have unusual radiological features. Brain biopsy may be necessary to confirm PML in cases associated with atypical clinical and radiological presentations.

Original language	English (US)
Pages (from-to)	113-116
Number of pages	4
Journal	Movement Disorders
Volume	8
Issue number	1
DOIs	https://doi.org/10.1002/mds.870080120
State	Published - 1993

Keywords

Acquired immunodeficiency syndrome
Akinetic‐rigid syndrome
Basal ganglia diseases
Bradykinesia
Magnetic resonance imaging
Parkinsonism
Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

Neurology
Clinical Neurology

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abstract = "A 13-year-old HIV-infected girl presented with a rapidly progressive akinetic-rigid syndrome. Cranial magnetic resonance imaging revealed bilateral centrum semiovale lesions extending into the basal ganglia. Detailed histopathological study of a biopsy specimen from the involved regions resulted in a diagnosis of progressive multifocal leukoencephalopathy (PML). This case illustrates that an akinetic-rigid syndrome may be a rare presentation of PML. HIV-related PML may have unusual radiological features. Brain biopsy may be necessary to confirm PML in cases associated with atypical clinical and radiological presentations.",

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AU - Weiner, William J.

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