Akinetic-rigid syndrome in a 13-Year-Old girl with HIV-Related progressive multifocal leukoencephalopathy

Carlos Singer, J. R. Berger, B. C. Bowen, J. H. Bruce, W. J. Weiner

Research output: Contribution to journalArticle

29 Scopus citations


A 13-year-old HIV-infected girl presented with a rapidly progressive akinetic-rigid syndrome. Cranial magnetic resonance imaging revealed bilateral centrum semiovale lesions extending into the basal ganglia. Detailed histopathological study of a biopsy specimen from the involved regions resulted in a diagnosis of progressive multifocal leukoencephalopathy (PML). This case illustrates that an akinetic-rigid syndrome may be a rare presentation of PML. HIV-related PML may have unusual radiological features. Brain biopsy may be necessary to confirm PML in cases associated with atypical clinical and radiological presentations.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalMovement Disorders
Issue number1
StatePublished - Feb 12 1993


ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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