AKAPs: The architectural underpinnings of local cAMP signaling

Michael D. Kritzer, Jinliang Li, Kimberly Dodge-Kafka, Michael S. Kapiloff

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled "Local Signaling in Myocytes".

Original languageEnglish (US)
Pages (from-to)351-358
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Volume52
Issue number2
DOIs
StatePublished - Feb 2012

Keywords

  • AKAP
  • CAMP
  • Compartmentation
  • PKA
  • Scaffold
  • Signaling

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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