AKAPs: The architectural underpinnings of local cAMP signaling

Michael D. Kritzer; Jinliang Li; Kimberly Dodge-Kafka; Michael S. Kapiloff

doi:10.1016/j.yjmcc.2011.05.002

AKAPs: The architectural underpinnings of local cAMP signaling

Michael D. Kritzer, Jinliang Li, Kimberly Dodge-Kafka, Michael S. Kapiloff

Pediatrics

Research output: Contribution to journal › Review article

56 Scopus citations

Abstract

The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled "Local Signaling in Myocytes".

Original language	English (US)
Pages (from-to)	351-358
Number of pages	8
Journal	Journal of Molecular and Cellular Cardiology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/j.yjmcc.2011.05.002
State	Published - Feb 1 2012

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Keywords

AKAP
CAMP
Compartmentation
PKA
Scaffold
Signaling

ASJC Scopus subject areas

Molecular Biology
Cardiology and Cardiovascular Medicine

Cite this

Kritzer, M. D., Li, J., Dodge-Kafka, K., & Kapiloff, M. S. (2012). AKAPs: The architectural underpinnings of local cAMP signaling. Journal of Molecular and Cellular Cardiology, 52(2), 351-358. https://doi.org/10.1016/j.yjmcc.2011.05.002

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10.1016/j.yjmcc.2011.05.002