AKAPs: The architectural underpinnings of local cAMP signaling

Michael D. Kritzer; Jinliang Li; Kimberly Dodge-Kafka; Michael S. Kapiloff

doi:10.1016/j.yjmcc.2011.05.002

AKAPs: The architectural underpinnings of local cAMP signaling

Michael D. Kritzer, Jinliang Li, Kimberly Dodge-Kafka, Michael S. Kapiloff

Research output: Contribution to journal › Review article › peer-review

75 Scopus citations

Abstract

The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled "Local Signaling in Myocytes".

Original language	English (US)
Pages (from-to)	351-358
Number of pages	8
Journal	Journal of Molecular and Cellular Cardiology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/j.yjmcc.2011.05.002
State	Published - Feb 2012
Externally published	Yes

Keywords

AKAP
CAMP
Compartmentation
PKA
Scaffold
Signaling

ASJC Scopus subject areas

Molecular Biology
Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.yjmcc.2011.05.002

Cite this

@article{14f0c59e81ad47118e94daca9b09ca97,

title = "AKAPs: The architectural underpinnings of local cAMP signaling",

abstract = "The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled {"}Local Signaling in Myocytes{"}.",

keywords = "AKAP, CAMP, Compartmentation, PKA, Scaffold, Signaling",

author = "Kritzer, {Michael D.} and Jinliang Li and Kimberly Dodge-Kafka and Kapiloff, {Michael S.}",

note = "Funding Information: This work was supported by NIH grants HL82705 to KDK and HL075398 to MSK and American Heart Association awards to MK and JL.",

year = "2012",

month = feb,

doi = "10.1016/j.yjmcc.2011.05.002",

language = "English (US)",

volume = "52",

pages = "351--358",

journal = "Journal of Molecular and Cellular Cardiology",

issn = "0022-2828",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - AKAPs

T2 - The architectural underpinnings of local cAMP signaling

AU - Kritzer, Michael D.

AU - Li, Jinliang

AU - Dodge-Kafka, Kimberly

AU - Kapiloff, Michael S.

N1 - Funding Information: This work was supported by NIH grants HL82705 to KDK and HL075398 to MSK and American Heart Association awards to MK and JL.

PY - 2012/2

Y1 - 2012/2

N2 - The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled "Local Signaling in Myocytes".

AB - The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled "Local Signaling in Myocytes".

KW - AKAP

KW - CAMP

KW - Compartmentation

KW - PKA

KW - Scaffold

KW - Signaling

UR - http://www.scopus.com/inward/record.url?scp=84855998675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855998675&partnerID=8YFLogxK

U2 - 10.1016/j.yjmcc.2011.05.002

DO - 10.1016/j.yjmcc.2011.05.002

M3 - Review article

C2 - 21600214

AN - SCOPUS:84855998675

VL - 52

SP - 351

EP - 358

JO - Journal of Molecular and Cellular Cardiology

JF - Journal of Molecular and Cellular Cardiology

SN - 0022-2828

IS - 2

ER -

AKAPs: The architectural underpinnings of local cAMP signaling

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this