AKAPs: The architectural underpinnings of local cAMP signaling

Michael D. Kritzer; Jinliang Li; Kimberly Dodge-Kafka; Michael S. Kapiloff

doi:10.1016/j.yjmcc.2011.05.002

AKAPs: The architectural underpinnings of local cAMP signaling

Michael D. Kritzer, Jinliang Li, Kimberly Dodge-Kafka, Michael S. Kapiloff

Pediatrics

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled "Local Signaling in Myocytes".

Original language	English (US)
Pages (from-to)	351-358
Number of pages	8
Journal	Journal of Molecular and Cellular Cardiology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/j.yjmcc.2011.05.002
State	Published - Feb 2012

Keywords

AKAP
CAMP
Compartmentation
PKA
Scaffold
Signaling

ASJC Scopus subject areas

Molecular Biology
Cardiology and Cardiovascular Medicine

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10.1016/j.yjmcc.2011.05.002

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abstract = "The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled {"}Local Signaling in Myocytes{"}.",

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note = "Funding Information: This work was supported by NIH grants HL82705 to KDK and HL075398 to MSK and American Heart Association awards to MK and JL.",

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AU - Kapiloff, Michael S.

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AB - The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled "Local Signaling in Myocytes".

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KW - Scaffold

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AKAPs: The architectural underpinnings of local cAMP signaling

Abstract

Keywords

ASJC Scopus subject areas

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