Abstract
The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled "Local Signaling in Myocytes".
Original language | English (US) |
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Pages (from-to) | 351-358 |
Number of pages | 8 |
Journal | Journal of Molecular and Cellular Cardiology |
Volume | 52 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2012 |
Keywords
- AKAP
- CAMP
- Compartmentation
- PKA
- Scaffold
- Signaling
ASJC Scopus subject areas
- Molecular Biology
- Cardiology and Cardiovascular Medicine