Airway tissue engineering: An update

Jonathan M. Fishman, Katherine Wiles, Mark W. Lowdell, Paolo De Coppi, Martin J. Elliott, Anthony Atala, Martin A. Birchall

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Introduction: Prosthetic materials, autologous tissues, cryopreserved homografts and allogeneic tissues have thus far proven unsuccessful in providing long-term functional solutions to extensive upper airway disease and damage. Research is therefore focusing on the rapidly expanding fields of regenerative medicine and tissue engineering in order to provide stem cell-based constructs for airway reconstruction, substitution and/or regeneration. Areas covered: Advances in stem cell technology, biomaterials and growth factor interactions have been instrumental in guiding optimization of tissue-engineered airways, leading to several first-in-man studies investigating stem cell-based tissue-engineered tracheal transplants in patients. Here, we summarize current progress, outstanding research questions, as well as future directions within the field. Expert opinion: The complex immune interaction between the transplant and host in vivo is only beginning to be untangled. Recent progress in our understanding of stem cell biology, decellularization techniques, biomaterials and transplantation immunobiology offers the prospect of transplanting airways without the need for lifelong immunosuppression. In addition, progress in airway revascularization, reinnervation and ever-increasingly sophisticated bioreactor design is opening up new avenues for the construction of a tissue-engineered larynx. Finally, 3D printing is a novel technique with the potential to render microscopic control over how cells are incorporated and grown onto the tissue-engineered airway.

Original languageEnglish (US)
Pages (from-to)1477-1491
Number of pages15
JournalExpert Opinion on Biological Therapy
Volume14
Issue number10
DOIs
StatePublished - Oct 1 2014

Keywords

  • Airway management
  • Angiogenesis
  • Artificial organs
  • Biocompatible materials
  • Bioreactors
  • Larynx
  • Regenerative medicine
  • Stem cells
  • Tissue engineering
  • Tissue scaffolds
  • Trachea
  • Transplantation

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry
  • Drug Discovery

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  • Cite this

    Fishman, J. M., Wiles, K., Lowdell, M. W., De Coppi, P., Elliott, M. J., Atala, A., & Birchall, M. A. (2014). Airway tissue engineering: An update. Expert Opinion on Biological Therapy, 14(10), 1477-1491. https://doi.org/10.1517/14712598.2014.938631