Airway hydration, apical K+ secretion, and the Large-conductance, Ca2+-activated and voltage-dependent potassium (BK) channel

Adrian Kis, Stefanie Krick, Nathalie Baumlin, Matthias A Salathe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Large-conductance, calcium-activated, and voltage-gated K+(BK) channels are expressed in many tissues of the human body, where they play important roles in signaling not only in excitable but also in nonexcitable cells. Because BK channel properties are rendered in part by their association with four β and four γ subunits, their channel function can differ drastically, depending on in which cellular system they are expressed. Recent studies verify the importance of apically expressed BK channels for airway surface liquid homeostasis and therefore of their significant role in mucociliary clearance. Here, we review evidence that inflammatory cytokines, which contribute to airway diseases, can lead to reduced BK activity via a functional down-regulation of the 7 regulatory subunit LRRC26. Therefore, manipulation of LRRC26 and pharmacological opening of BK channels represent two novel concepts of targeting epithelial dysfunction in inflammatory airway diseases.

Original languageEnglish (US)
Pages (from-to)S163-S168
JournalAnnals of the American Thoracic Society
Volume13
DOIs
StatePublished - Apr 1 2016

Fingerprint

Large-Conductance Calcium-Activated Potassium Channels
Potassium Channels
Mucociliary Clearance
Voltage-Gated Potassium Channels
Human Body
Homeostasis
Down-Regulation
Pharmacology
Cytokines
Calcium

Keywords

  • Airway surface liquid
  • BK channels
  • Mucociliary clearance

ASJC Scopus subject areas

  • Medicine(all)
  • Pulmonary and Respiratory Medicine

Cite this

Airway hydration, apical K+ secretion, and the Large-conductance, Ca2+-activated and voltage-dependent potassium (BK) channel. / Kis, Adrian; Krick, Stefanie; Baumlin, Nathalie; Salathe, Matthias A.

In: Annals of the American Thoracic Society, Vol. 13, 01.04.2016, p. S163-S168.

Research output: Contribution to journalArticle

Kis, Adrian ; Krick, Stefanie ; Baumlin, Nathalie ; Salathe, Matthias A. / Airway hydration, apical K+ secretion, and the Large-conductance, Ca2+-activated and voltage-dependent potassium (BK) channel. In: Annals of the American Thoracic Society. 2016 ; Vol. 13. pp. S163-S168.
@article{8dc8443b90ab47408024bbe0901d1f80,
title = "Airway hydration, apical K+ secretion, and the Large-conductance, Ca2+-activated and voltage-dependent potassium (BK) channel",
abstract = "Large-conductance, calcium-activated, and voltage-gated K+(BK) channels are expressed in many tissues of the human body, where they play important roles in signaling not only in excitable but also in nonexcitable cells. Because BK channel properties are rendered in part by their association with four β and four γ subunits, their channel function can differ drastically, depending on in which cellular system they are expressed. Recent studies verify the importance of apically expressed BK channels for airway surface liquid homeostasis and therefore of their significant role in mucociliary clearance. Here, we review evidence that inflammatory cytokines, which contribute to airway diseases, can lead to reduced BK activity via a functional down-regulation of the 7 regulatory subunit LRRC26. Therefore, manipulation of LRRC26 and pharmacological opening of BK channels represent two novel concepts of targeting epithelial dysfunction in inflammatory airway diseases.",
keywords = "Airway surface liquid, BK channels, Mucociliary clearance",
author = "Adrian Kis and Stefanie Krick and Nathalie Baumlin and Salathe, {Matthias A}",
year = "2016",
month = "4",
day = "1",
doi = "10.1513/AnnalsATS.201507-405KV",
language = "English (US)",
volume = "13",
pages = "S163--S168",
journal = "Annals of the American Thoracic Society",
issn = "2325-6621",
publisher = "American Thoracic Society",

}

TY - JOUR

T1 - Airway hydration, apical K+ secretion, and the Large-conductance, Ca2+-activated and voltage-dependent potassium (BK) channel

AU - Kis, Adrian

AU - Krick, Stefanie

AU - Baumlin, Nathalie

AU - Salathe, Matthias A

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Large-conductance, calcium-activated, and voltage-gated K+(BK) channels are expressed in many tissues of the human body, where they play important roles in signaling not only in excitable but also in nonexcitable cells. Because BK channel properties are rendered in part by their association with four β and four γ subunits, their channel function can differ drastically, depending on in which cellular system they are expressed. Recent studies verify the importance of apically expressed BK channels for airway surface liquid homeostasis and therefore of their significant role in mucociliary clearance. Here, we review evidence that inflammatory cytokines, which contribute to airway diseases, can lead to reduced BK activity via a functional down-regulation of the 7 regulatory subunit LRRC26. Therefore, manipulation of LRRC26 and pharmacological opening of BK channels represent two novel concepts of targeting epithelial dysfunction in inflammatory airway diseases.

AB - Large-conductance, calcium-activated, and voltage-gated K+(BK) channels are expressed in many tissues of the human body, where they play important roles in signaling not only in excitable but also in nonexcitable cells. Because BK channel properties are rendered in part by their association with four β and four γ subunits, their channel function can differ drastically, depending on in which cellular system they are expressed. Recent studies verify the importance of apically expressed BK channels for airway surface liquid homeostasis and therefore of their significant role in mucociliary clearance. Here, we review evidence that inflammatory cytokines, which contribute to airway diseases, can lead to reduced BK activity via a functional down-regulation of the 7 regulatory subunit LRRC26. Therefore, manipulation of LRRC26 and pharmacological opening of BK channels represent two novel concepts of targeting epithelial dysfunction in inflammatory airway diseases.

KW - Airway surface liquid

KW - BK channels

KW - Mucociliary clearance

UR - http://www.scopus.com/inward/record.url?scp=84989231095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989231095&partnerID=8YFLogxK

U2 - 10.1513/AnnalsATS.201507-405KV

DO - 10.1513/AnnalsATS.201507-405KV

M3 - Article

C2 - 27115952

AN - SCOPUS:84989231095

VL - 13

SP - S163-S168

JO - Annals of the American Thoracic Society

JF - Annals of the American Thoracic Society

SN - 2325-6621

ER -