Airway blood flow reactivity in smokers

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Cigarette smoking has been associated with impaired endothelium-dependent relaxation responses in the brachial and coronary arteries (endothelial dysfunction). The aim of the present study was to determine if the airway circulation is also affected and if airway treatment has an effect on endothelial function. Airway blood flow (Qaw) responses to inhaled albuterol as an index of endothelial function were measured in age-matched healthy current smokers, healthy ex-smokers, ex-smokers with COPD and healthy lifetime non-smokers; in the ex-smokers with COPD, the albuterol responsiveness was repeated after a 4-week treatment with an inhaled glucocorticoid/β2-adrenergic agonist combination drug. Mean baseline Qaw was similar in the four groups. Albuterol inhalation increased mean Qaw in lifetime non-smokers (50.1±8.3%; p < 0.0 5) and in healthy ex-smokers (37.2±3.4%; p < 0.0 5) but not in healthy current smokers (13.9±3.2%; p=NS) and ex-smokers with COPD (9.7±4.5%; p=NS). While drug treatment per se did not change Qaw significantly, it restored albuterol responsiveness (+67.6±11.1%; p < 0.0 5) in the ex-smokers with COPD. Thus, cigarette smoking is associated with endothelial dysfunction in the airway, with a partial recovery of endothelial function after smoking cessation in healthy ex-smokers but not in ex-smokers with COPD. In the latter, combined glucocorticoid/β2-adrenergic agonist treatment restores albuterol responsiveness.

Original languageEnglish
Pages (from-to)126-129
Number of pages4
JournalPulmonary Pharmacology and Therapeutics
Volume20
Issue number2
DOIs
StatePublished - Apr 1 2007

Fingerprint

Albuterol
Chronic Obstructive Pulmonary Disease
Blood
Adrenergic Agonists
Tobacco Products
Glucocorticoids
Smoking
Drug therapy
Brachial Artery
Recovery of Function
Smoking Cessation
Drug Combinations
Inhalation
Endothelium
Coronary Vessels
Recovery
Pharmaceutical Preparations

Keywords

  • Airway blood flow
  • Albuterol
  • Cigarette smoke
  • Endothelial dysfunction

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology

Cite this

Airway blood flow reactivity in smokers. / Wanner, Adam; Campos, Michael A; Mendes, Eliana.

In: Pulmonary Pharmacology and Therapeutics, Vol. 20, No. 2, 01.04.2007, p. 126-129.

Research output: Contribution to journalArticle

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