AIDS-related glomerulopathy

Occurrence in specific risk groups

V. Pardo, R. Meneses, L. Ossa, D. J. Jaffe, J. Strauss, David Roth, J. J. Bourgoignie

Research output: Contribution to journalArticle

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Abstract

The histopathology and incidence of AIDS-related glomerulopathy was evaluated by renal biopsy (N = 24) or at autopsy in 159 patients, including 131 adults and 28 infants and children with AIDS. Thirty-five patients had overt clinical manifestations of renal disease characterized by a nephrotic syndrome with focal and segmental glomerular sclerosis (FSS). Fifteen patients had diffuse glomerular mesangial hyperplasia (MH) without or with minimal clinical renal disease and 109 had intact or minimally involved glomeruli. Whereas 15 of 30 (50%) i.v. drug users with AIDS had evidence of renal disease, only one of 53 (2%) homosexuals had clinical renal disease and only 6 (11%) had histologic evidence of glomerular pathology. The study confirms the important risk of i.v. drug use as a pathogenic factor of renal disease and shows a rarity of renal disease in homosexual or bisexual men with AIDS. On the other hand, 30% of adult Haitians with AIDS had FSS or diffuse MH, although i.v. drug use is not an important risk factor in this population. Moreover, eight of 28 (29%) children with perinatal AIDS had evidence of renal involvement, including four with a nephrotic syndrome and FSS. The data provide strong evidence for the existence of an AIDS-related glomerulopathy independent of i.v. drug use, but suggest that unrecognized co-factors may be important in the development of renal disease.

Original languageEnglish
Pages (from-to)1167-1173
Number of pages7
JournalKidney International
Volume31
Issue number5
StatePublished - Jul 6 1987
Externally publishedYes

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Acquired Immunodeficiency Syndrome
Kidney
Nephrotic Syndrome
Sclerosis
Hyperplasia
Pharmaceutical Preparations
Drug Users
Autopsy
Pathology
Biopsy
Incidence
Population
Sexual Minorities

ASJC Scopus subject areas

  • Nephrology

Cite this

Pardo, V., Meneses, R., Ossa, L., Jaffe, D. J., Strauss, J., Roth, D., & Bourgoignie, J. J. (1987). AIDS-related glomerulopathy: Occurrence in specific risk groups. Kidney International, 31(5), 1167-1173.

AIDS-related glomerulopathy : Occurrence in specific risk groups. / Pardo, V.; Meneses, R.; Ossa, L.; Jaffe, D. J.; Strauss, J.; Roth, David; Bourgoignie, J. J.

In: Kidney International, Vol. 31, No. 5, 06.07.1987, p. 1167-1173.

Research output: Contribution to journalArticle

Pardo, V, Meneses, R, Ossa, L, Jaffe, DJ, Strauss, J, Roth, D & Bourgoignie, JJ 1987, 'AIDS-related glomerulopathy: Occurrence in specific risk groups', Kidney International, vol. 31, no. 5, pp. 1167-1173.
Pardo V, Meneses R, Ossa L, Jaffe DJ, Strauss J, Roth D et al. AIDS-related glomerulopathy: Occurrence in specific risk groups. Kidney International. 1987 Jul 6;31(5):1167-1173.
Pardo, V. ; Meneses, R. ; Ossa, L. ; Jaffe, D. J. ; Strauss, J. ; Roth, David ; Bourgoignie, J. J. / AIDS-related glomerulopathy : Occurrence in specific risk groups. In: Kidney International. 1987 ; Vol. 31, No. 5. pp. 1167-1173.
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