Abstract
A case of acute, transient agranulocytosis and thrombocytopenia associated with ingestion of dipyrone is reported. This once widely used analgesic, which is now banned in the United States, was obtained by the patient as 'aspirin' while traveling in Mexico. Studies of the effects of this patient's serum on purified CD34+ marrow cells, which were highly enriched for hematopoietic progenitors, showed not only a drug-dependent suppression of the in vitro growth of myeloid progenitors, as has been reported previously, but also a drug-dependent suppression of primitive multipotential progenitors (CFU-Mix) and erythroid progenitors (BFU-E). These findings indicate that autoimmune, antibody-hapten interactions which have been reported to occur in dipyrone- and aminopyrine-induced agranulocytosis are not restricted to the neutrophil lineage.
| Original language | English |
|---|---|
| Pages (from-to) | 213-215 |
| Number of pages | 3 |
| Journal | American Journal of Hematology |
| Volume | 31 |
| Issue number | 3 |
| State | Published - Jan 1 1989 |
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ASJC Scopus subject areas
- Hematology
Cite this
Agranulocytosis associated with 'Mexican aspirin' (Dipyrone) : Evidence for an autoimmune mechanism affecting multipotential hematopoietic progenitors. / Hargis, J. B.; La Russa, V. F.; Redmond, J.; Kessler, S. W.; Wright, D. G.
In: American Journal of Hematology, Vol. 31, No. 3, 01.01.1989, p. 213-215.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Agranulocytosis associated with 'Mexican aspirin' (Dipyrone)
T2 - Evidence for an autoimmune mechanism affecting multipotential hematopoietic progenitors
AU - Hargis, J. B.
AU - La Russa, V. F.
AU - Redmond, J.
AU - Kessler, S. W.
AU - Wright, D. G.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - A case of acute, transient agranulocytosis and thrombocytopenia associated with ingestion of dipyrone is reported. This once widely used analgesic, which is now banned in the United States, was obtained by the patient as 'aspirin' while traveling in Mexico. Studies of the effects of this patient's serum on purified CD34+ marrow cells, which were highly enriched for hematopoietic progenitors, showed not only a drug-dependent suppression of the in vitro growth of myeloid progenitors, as has been reported previously, but also a drug-dependent suppression of primitive multipotential progenitors (CFU-Mix) and erythroid progenitors (BFU-E). These findings indicate that autoimmune, antibody-hapten interactions which have been reported to occur in dipyrone- and aminopyrine-induced agranulocytosis are not restricted to the neutrophil lineage.
AB - A case of acute, transient agranulocytosis and thrombocytopenia associated with ingestion of dipyrone is reported. This once widely used analgesic, which is now banned in the United States, was obtained by the patient as 'aspirin' while traveling in Mexico. Studies of the effects of this patient's serum on purified CD34+ marrow cells, which were highly enriched for hematopoietic progenitors, showed not only a drug-dependent suppression of the in vitro growth of myeloid progenitors, as has been reported previously, but also a drug-dependent suppression of primitive multipotential progenitors (CFU-Mix) and erythroid progenitors (BFU-E). These findings indicate that autoimmune, antibody-hapten interactions which have been reported to occur in dipyrone- and aminopyrine-induced agranulocytosis are not restricted to the neutrophil lineage.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024334533&partnerID=8YFLogxK
M3 - Article
C2 - 2741915
AN - SCOPUS:0024334533
VL - 31
SP - 213
EP - 215
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 3
ER -