Agranulocytosis associated with 'Mexican aspirin' (Dipyrone): Evidence for an autoimmune mechanism affecting multipotential hematopoietic progenitors

J. B. Hargis, V. F. La Russa, J. Redmond, S. W. Kessler, D. G. Wright

Research output: Contribution to journalArticle

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Abstract

A case of acute, transient agranulocytosis and thrombocytopenia associated with ingestion of dipyrone is reported. This once widely used analgesic, which is now banned in the United States, was obtained by the patient as 'aspirin' while traveling in Mexico. Studies of the effects of this patient's serum on purified CD34+ marrow cells, which were highly enriched for hematopoietic progenitors, showed not only a drug-dependent suppression of the in vitro growth of myeloid progenitors, as has been reported previously, but also a drug-dependent suppression of primitive multipotential progenitors (CFU-Mix) and erythroid progenitors (BFU-E). These findings indicate that autoimmune, antibody-hapten interactions which have been reported to occur in dipyrone- and aminopyrine-induced agranulocytosis are not restricted to the neutrophil lineage.

Original languageEnglish
Pages (from-to)213-215
Number of pages3
JournalAmerican Journal of Hematology
Volume31
Issue number3
StatePublished - Jan 1 1989

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Dipyrone
Agranulocytosis
Aspirin
Aminopyrine
Erythroid Precursor Cells
Haptens
Mexico
Thrombocytopenia
Pharmaceutical Preparations
Analgesics
Neutrophils
Eating
Bone Marrow
Antibodies
Growth
Serum
In Vitro Techniques

ASJC Scopus subject areas

  • Hematology

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Agranulocytosis associated with 'Mexican aspirin' (Dipyrone) : Evidence for an autoimmune mechanism affecting multipotential hematopoietic progenitors. / Hargis, J. B.; La Russa, V. F.; Redmond, J.; Kessler, S. W.; Wright, D. G.

In: American Journal of Hematology, Vol. 31, No. 3, 01.01.1989, p. 213-215.

Research output: Contribution to journalArticle

Hargis, J. B. ; La Russa, V. F. ; Redmond, J. ; Kessler, S. W. ; Wright, D. G. / Agranulocytosis associated with 'Mexican aspirin' (Dipyrone) : Evidence for an autoimmune mechanism affecting multipotential hematopoietic progenitors. In: American Journal of Hematology. 1989 ; Vol. 31, No. 3. pp. 213-215.
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