Aging, progenitor cell exhaustion, and atherosclerosis

Frederick M. Rauscher, Pascal Goldschmidt-Clermont, Bryce H. Davis, Tao Wang, David Gregg, Priya Ramaswami, Anne M. Pippen, Brian H. Annex, Chunming Dong, Doris A. Taylor

Research output: Contribution to journalArticle

584 Citations (Scopus)

Abstract

Background - Atherosclerosis is largely attributed to chronic vascular injury, as occurs with excess cholesterol; however, the effect of concomitant vascular aging remains unexplained. We hypothesize that the effect of time in atherosclerosis progression is related to obsolescence of endogenous progenitor cells that normally repair and rejuvenate the arteries. Methods and Results - Here we show that chronic treatment with bone marrow-derived progenitor cells from young nonatherosclerotic ApoE-/- mice prevents atherosclerosis progression in ApoE-/- recipients despite persistent hypercholesterolemia. In contrast, treatment with bone marrow cells from older ApoE-/- mice with atherosclerosis is much less effective. Cells with vascular progenitor potential are decreased in the bone marrow of aging ApoE-/- mice, but cells injected from donor mice engraft on recipient arteries in areas at risk for atherosclerotic injury. Conclusions - Our data indicate that progressive progenitor cell deficits may contribute to the development of atherosclerosis.

Original languageEnglish
Pages (from-to)457-463
Number of pages7
JournalCirculation
Volume108
Issue number4
DOIs
StatePublished - Jul 29 2003
Externally publishedYes

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Apolipoproteins E
Atherosclerosis
Stem Cells
Blood Vessels
Arteries
Bone Marrow
Vascular System Injuries
Hypercholesterolemia
Bone Marrow Cells
Cholesterol
Wounds and Injuries

Keywords

  • Aging
  • Atherosclerosis
  • Stem cells

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Rauscher, F. M., Goldschmidt-Clermont, P., Davis, B. H., Wang, T., Gregg, D., Ramaswami, P., ... Taylor, D. A. (2003). Aging, progenitor cell exhaustion, and atherosclerosis. Circulation, 108(4), 457-463. https://doi.org/10.1161/01.CIR.0000082924.75945.48

Aging, progenitor cell exhaustion, and atherosclerosis. / Rauscher, Frederick M.; Goldschmidt-Clermont, Pascal; Davis, Bryce H.; Wang, Tao; Gregg, David; Ramaswami, Priya; Pippen, Anne M.; Annex, Brian H.; Dong, Chunming; Taylor, Doris A.

In: Circulation, Vol. 108, No. 4, 29.07.2003, p. 457-463.

Research output: Contribution to journalArticle

Rauscher, FM, Goldschmidt-Clermont, P, Davis, BH, Wang, T, Gregg, D, Ramaswami, P, Pippen, AM, Annex, BH, Dong, C & Taylor, DA 2003, 'Aging, progenitor cell exhaustion, and atherosclerosis', Circulation, vol. 108, no. 4, pp. 457-463. https://doi.org/10.1161/01.CIR.0000082924.75945.48
Rauscher FM, Goldschmidt-Clermont P, Davis BH, Wang T, Gregg D, Ramaswami P et al. Aging, progenitor cell exhaustion, and atherosclerosis. Circulation. 2003 Jul 29;108(4):457-463. https://doi.org/10.1161/01.CIR.0000082924.75945.48
Rauscher, Frederick M. ; Goldschmidt-Clermont, Pascal ; Davis, Bryce H. ; Wang, Tao ; Gregg, David ; Ramaswami, Priya ; Pippen, Anne M. ; Annex, Brian H. ; Dong, Chunming ; Taylor, Doris A. / Aging, progenitor cell exhaustion, and atherosclerosis. In: Circulation. 2003 ; Vol. 108, No. 4. pp. 457-463.
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