Aging of the recipients but not of the bone marrow donors enhances autoimmunity in syngeneic radiation chimeras

Gino Doria, Camillo Mancini, Masanori Utsuyama, Daniela Frasca, Katsuiku Hirokawa

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Young and old mice have been lethally irradiated and injected with syngeneic bone marrow cells from young or old donors to investigate whether self reactivity in old mice results from age-related damage of the radioresistant stromal cells and/or of the bone marrow hematopoietic cells. Thymus and spleen cell repopulations and mitotic responses at 3 months after irradiation are lower in old than in young recipients, suggesting age-related accumulation of stromal cell damage in the thymus as well as in other central and peripheral lymphoid tissues. The same efficiency of bone marrow cells from young and old donors to repopulate the thymus and spleen in recipients of equal age rules out the detrimental effects of aging on stem cells as well as T and B cell precursors. The serum concentration of auto-antibody and glomerular lesions at 3 and 9 months after irradiation were more pronounced in old than in young recipients and displayed no difference in recipients of equal age, regardless of the age of the bone marrow cell donors. These findings support the possibility that age-related damage of stromal cells induces disregulation of the immune system leading to autoimmune phenomena.

Original languageEnglish
Pages (from-to)131-142
Number of pages12
JournalMechanisms of Ageing and Development
Volume95
Issue number1-2
DOIs
StatePublished - Apr 1 1997
Externally publishedYes

Fingerprint

Radiation Chimera
Autoimmunity
Bone Marrow Cells
Bone
Stromal Cells
Thymus
Aging of materials
Bone Marrow
Cells
Thymus Gland
Radiation
Spleen
T-Lymphoid Precursor Cells
Irradiation
Lymphoid Tissue
Immune system
Immune System
Stem cells
B-Lymphocytes
Stem Cells

Keywords

  • Aging
  • Autoimmunity
  • B cells
  • Radiation chimeras
  • T cells

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Aging of the recipients but not of the bone marrow donors enhances autoimmunity in syngeneic radiation chimeras. / Doria, Gino; Mancini, Camillo; Utsuyama, Masanori; Frasca, Daniela; Hirokawa, Katsuiku.

In: Mechanisms of Ageing and Development, Vol. 95, No. 1-2, 01.04.1997, p. 131-142.

Research output: Contribution to journalArticle

Doria, Gino ; Mancini, Camillo ; Utsuyama, Masanori ; Frasca, Daniela ; Hirokawa, Katsuiku. / Aging of the recipients but not of the bone marrow donors enhances autoimmunity in syngeneic radiation chimeras. In: Mechanisms of Ageing and Development. 1997 ; Vol. 95, No. 1-2. pp. 131-142.
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