Abstract
The increase in the prevalence of obesity represents a worldwide phenomenon in all age groups and is pathologically and genetically correlated with several metabolic and cardiovascular diseases, representing the most frequent age-related diseases. Obesity superimposed on aging drastically increases chronic low-grade inflammation (inflammaging), which is an important link between obesity, insulin resistance, and age-associated diseases. Immune cells of both the innate and the adaptive immune systems infiltrate the adipose tissue (AT) and during obesity induce inflammatory responses associated with metabolic switches and changes in phenotypes and function of immune cell subsets. Obesity poses new health problems especially when it occurs in the context of other diseases, many of them frequently affect elderly subjects. An emerging problem is the decreased proportion of patients with obesity achieving clinical response to therapy. In this review, we will discuss the reciprocal influences of immune cell and AT inflammation in aging and age-associated diseases and the complex relationship of nutrient and energy-sensing homeostatic checkpoints, which contribute to shape the phenotype of the AT. We will specifically examine type-2 diabetes, rheumatoid arthritis, osteoarthritis, cognitive impairment, and dementia, where obesity plays a significant role, also in shaping some clinical aspects. ©
| Original language | English (US) |
|---|---|
| Article number | 1745 |
| Journal | Frontiers in Immunology |
| Volume | 8 |
| Issue number | DEC |
| DOIs | |
| State | Published - Dec 7 2017 |
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Keywords
- Aging
- Inflammation
- Obesity
- Rheumatoid arthritis
- Type-2 diabetes
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Aging, obesity, and inflammatory age-related diseases. / Frasca, Daniela; Blomberg, Bonnie B; Paganelli, Roberto.
In: Frontiers in Immunology, Vol. 8, No. DEC, 1745, 07.12.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aging, obesity, and inflammatory age-related diseases
AU - Frasca, Daniela
AU - Blomberg, Bonnie B
AU - Paganelli, Roberto
PY - 2017/12/7
Y1 - 2017/12/7
N2 - The increase in the prevalence of obesity represents a worldwide phenomenon in all age groups and is pathologically and genetically correlated with several metabolic and cardiovascular diseases, representing the most frequent age-related diseases. Obesity superimposed on aging drastically increases chronic low-grade inflammation (inflammaging), which is an important link between obesity, insulin resistance, and age-associated diseases. Immune cells of both the innate and the adaptive immune systems infiltrate the adipose tissue (AT) and during obesity induce inflammatory responses associated with metabolic switches and changes in phenotypes and function of immune cell subsets. Obesity poses new health problems especially when it occurs in the context of other diseases, many of them frequently affect elderly subjects. An emerging problem is the decreased proportion of patients with obesity achieving clinical response to therapy. In this review, we will discuss the reciprocal influences of immune cell and AT inflammation in aging and age-associated diseases and the complex relationship of nutrient and energy-sensing homeostatic checkpoints, which contribute to shape the phenotype of the AT. We will specifically examine type-2 diabetes, rheumatoid arthritis, osteoarthritis, cognitive impairment, and dementia, where obesity plays a significant role, also in shaping some clinical aspects. ©
AB - The increase in the prevalence of obesity represents a worldwide phenomenon in all age groups and is pathologically and genetically correlated with several metabolic and cardiovascular diseases, representing the most frequent age-related diseases. Obesity superimposed on aging drastically increases chronic low-grade inflammation (inflammaging), which is an important link between obesity, insulin resistance, and age-associated diseases. Immune cells of both the innate and the adaptive immune systems infiltrate the adipose tissue (AT) and during obesity induce inflammatory responses associated with metabolic switches and changes in phenotypes and function of immune cell subsets. Obesity poses new health problems especially when it occurs in the context of other diseases, many of them frequently affect elderly subjects. An emerging problem is the decreased proportion of patients with obesity achieving clinical response to therapy. In this review, we will discuss the reciprocal influences of immune cell and AT inflammation in aging and age-associated diseases and the complex relationship of nutrient and energy-sensing homeostatic checkpoints, which contribute to shape the phenotype of the AT. We will specifically examine type-2 diabetes, rheumatoid arthritis, osteoarthritis, cognitive impairment, and dementia, where obesity plays a significant role, also in shaping some clinical aspects. ©
KW - Aging
KW - Inflammation
KW - Obesity
KW - Rheumatoid arthritis
KW - Type-2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85037666279&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85037666279&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2017.01745
DO - 10.3389/fimmu.2017.01745
M3 - Article
AN - SCOPUS:85037666279
VL - 8
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
IS - DEC
M1 - 1745
ER -