Aging impairs regulation of intracellular pH in rat hippocampal slices

Eugene L. Roberts, Thomas J. Sick

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


We investigated whether aging changed H+ homeostasis in hippocampal slices bathed in HEPES buffer. Intracellular pH in hippocampal slices from rats aged 26-27 months (7.06 ± 0.02) was significantly lower compared with that in slices from rats aged 6-7 months (7.16 ± 0.04). Age did not influence extracellular pH. Age-related reductions in intracellular pH may reflect altered pH regulation that potentially affects brain function and could contribute to the increased vulnerability of the aged brain to metabolic stress.

Original languageEnglish (US)
Pages (from-to)339-342
Number of pages4
JournalBrain research
Issue number2
StatePublished - Oct 7 1996


  • Age
  • Brain slice
  • Fluorescence
  • Hippocampus
  • pH regulation

ASJC Scopus subject areas

  • Neuroscience(all)


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