Aging impairs regulation of intracellular pH in rat hippocampal slices

Eugene L. Roberts; Thomas J. Sick

doi:10.1016/0006-8993(96)00925-0

Aging impairs regulation of intracellular pH in rat hippocampal slices

Eugene L. Roberts, Thomas J. Sick

Neurology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We investigated whether aging changed H⁺ homeostasis in hippocampal slices bathed in HEPES buffer. Intracellular pH in hippocampal slices from rats aged 26-27 months (7.06 ± 0.02) was significantly lower compared with that in slices from rats aged 6-7 months (7.16 ± 0.04). Age did not influence extracellular pH. Age-related reductions in intracellular pH may reflect altered pH regulation that potentially affects brain function and could contribute to the increased vulnerability of the aged brain to metabolic stress.

Original language	English (US)
Pages (from-to)	339-342
Number of pages	4
Journal	Brain Research
Volume	735
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(96)00925-0
State	Published - Oct 7 1996

Keywords

Age
Brain slice
Fluorescence
Hippocampus
pH regulation
SNARF

ASJC Scopus subject areas

Neuroscience(all)

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