@article{236f422d17bc4e6388e5fb1d6ac7e01e,
title = "Aging impairs regulation of intracellular pH in rat hippocampal slices",
abstract = "We investigated whether aging changed H+ homeostasis in hippocampal slices bathed in HEPES buffer. Intracellular pH in hippocampal slices from rats aged 26-27 months (7.06 ± 0.02) was significantly lower compared with that in slices from rats aged 6-7 months (7.16 ± 0.04). Age did not influence extracellular pH. Age-related reductions in intracellular pH may reflect altered pH regulation that potentially affects brain function and could contribute to the increased vulnerability of the aged brain to metabolic stress.",
keywords = "Age, Brain slice, Fluorescence, Hippocampus, pH regulation, SNARF",
author = "Roberts, {Eugene L.} and Sick, {Thomas J.}",
note = "Funding Information: This work was supportedb y grants from the National Instituteo n Aging (AG08710 (E.L.R.)) and from the National Institute of Neurological Disorders and Stroke (NS32167( T.J.S.)), and by a Grant-in-AidA ward from the American Heart Association, Florida Affiliate, Inc. (E.L.R.). We thank Dr. C.-P. Chih (South Florida VA Foundation)fo r her critical reading and helpful suggestions regardingth is manuscriptW. e also thank Dr. Michael Bodo, Dr. Zi-Cai Feng, Ms. Patricia Mumford, and Mr. Joe Feng (all of the Departmenot f Neurology)f or their technicaal ssistancwe ith the experimentsF.i nally,we thank Mr. Solomon Pikarsky for the computesr oftwareu sedfor data collectiona nd analysis.",
year = "1996",
month = oct,
day = "7",
doi = "10.1016/0006-8993(96)00925-0",
language = "English (US)",
volume = "735",
pages = "339--342",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",
}