Aging and the effects of MK-801 on anoxic damage in rat hippocampal slices

Eugene L. Roberts, David Wisotzky, Ching Ping Chih

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We examined whether age-related differences in N-methyl-D-aspartate (NMDA) receptor-mediated neurotoxicity contribute to the increased vulnerability of the aged brain to anoxic damage. In both adult and aged hippocampal slices, NMDA receptor blockade with MK-801 did not affect the onset of anoxic depolarization. MK-801 improved the postanoxic recovery of synaptic transmission by the same percentage in both age groups. Thus, the faster onset of anoxic depolarization and diminished postanoxic recovery of synaptic transmission seen in aged hippocampal slices cannot be attributed to age-related differences in NMDA receptor-mediated neurotoxicity.

Original languageEnglish (US)
Pages (from-to)321-324
Number of pages4
JournalBrain Research
Volume791
Issue number1-2
DOIs
StatePublished - Apr 27 1998

Keywords

  • Aging
  • Brain slice
  • Dizocilpine
  • Hippocampus
  • Hypoxia
  • Ion transport
  • Potassium ion homeostasis

ASJC Scopus subject areas

  • Neuroscience(all)

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