Abstract
Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.
Original language | English (US) |
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Pages (from-to) | 430-435 |
Number of pages | 6 |
Journal | Journal of Clinical Immunology |
Volume | 31 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2011 |
Keywords
- Aging
- B cells
- immunoglobulin class switch
- vaccination
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology