Aging affects human B cell responses

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.

Original languageEnglish (US)
Pages (from-to)430-435
Number of pages6
JournalJournal of Clinical Immunology
Issue number3
StatePublished - Jun 2011


  • Aging
  • B cells
  • immunoglobulin class switch
  • vaccination

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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