Aging affects human B cell responses

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.

Original languageEnglish (US)
Pages (from-to)430-435
Number of pages6
JournalJournal of Clinical Immunology
Volume31
Issue number3
DOIs
StatePublished - Jun 1 2011

Keywords

  • Aging
  • B cells
  • immunoglobulin class switch
  • vaccination

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Aging affects human B cell responses'. Together they form a unique fingerprint.

  • Cite this