Aging affects human B cell responses

Daniela Frasca; Bonnie B. Blomberg

doi:10.1007/s10875-010-9501-7

Aging affects human B cell responses

Daniela Frasca, Bonnie B. Blomberg

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.

Original language	English (US)
Pages (from-to)	430-435
Number of pages	6
Journal	Journal of Clinical Immunology
Volume	31
Issue number	3
DOIs	https://doi.org/10.1007/s10875-010-9501-7
State	Published - Jun 2011

Keywords

Aging
B cells
immunoglobulin class switch
vaccination

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10875-010-9501-7

Cite this

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AB - Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.

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KW - B cells

KW - immunoglobulin class switch

KW - vaccination

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Aging affects human B cell responses

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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