Aggressive Mediastinal Lymphomas

Xiaoqiong Wang, Wei Wang, Francisco Vega, Andres E. Quesada

Research output: Contribution to journalReview articlepeer-review


The mediastinum contains essentially all major intrathoracic organs except for the lungs. A variety of both benign and malignant tumors can involve the mediastinum, of which lymphoma is the most common malignancy. Compared to secondary mediastinal involvement by systemic lymphomas, primary mediastinal lymphomas are less common with several specific entities that are mainly confined to mediastinal lymph nodes, and/or thymus. This review will summarize the clinical, histologic, immunophenotypic and molecular genetic features of the most common and most aggressive primary mediastinal lymphomas as well as provide suggested immunohistochemistry panels and differential diagnoses.

Original languageEnglish (US)
JournalSeminars in Diagnostic Pathology
StateAccepted/In press - 2021
Externally publishedYes


  • Gray zone lymphoma
  • Hodgkin lymphoma
  • Lymphoma
  • Mediastinal
  • Primary mediastinal (thymic) large B-cell lymphoma
  • T-lymphoblastic leukemia/lymphoma
  • Thymus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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