Aggregation of insulin at the interface

Shanghao Li, Roger Leblanc

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Insulin has so far been the most important pharmaceutical peptide for diabetes treatment, assisting to regulate carbohydrate and fat metabolism in patients. However, aggregation of insulin occurs readily in almost every biopharmaceutical process, ranging from production, purification, storage, transportation, delivery, to in vivo utilization at the terminal. As interfaces and surfaces are ubiquitous in each process and strongly influence physical/chemical properties of insulin, it is necessary and fundamentally important to investigate the aggregation of insulin at various interfaces, such as aqueous-solid interface, water-oil interface, and air-water interface. The objective of this article is to briefly summarize recent progress on insulin aggregation at different interfaces, with special focus on the air-water interface using the Langmuir monolayer technique.

Original languageEnglish
Pages (from-to)1181-1188
Number of pages8
JournalJournal of Physical Chemistry B
Volume118
Issue number5
DOIs
StatePublished - Feb 6 2014

Fingerprint

insulin
Insulin
Agglomeration
Water
carbohydrate metabolism
water
monomolecular films
air
fats
metabolism
Carbohydrates
Medical problems
Air
Oils and fats
Metabolism
purification
chemical properties
Drug products
Chemical properties
Peptides

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Chemistry
  • Surfaces, Coatings and Films

Cite this

Aggregation of insulin at the interface. / Li, Shanghao; Leblanc, Roger.

In: Journal of Physical Chemistry B, Vol. 118, No. 5, 06.02.2014, p. 1181-1188.

Research output: Contribution to journalArticle

Li, Shanghao ; Leblanc, Roger. / Aggregation of insulin at the interface. In: Journal of Physical Chemistry B. 2014 ; Vol. 118, No. 5. pp. 1181-1188.
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