Aggregation behavior of poly(ethylene glycol-bl-propylene sulfide) di-And triblock copolymers in aqueous solution

Simona Cerritelli, Conlin P. O'neil, Diana Velluto, Antonella Fontana, Marc Adrian, Jacques Dubochet, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Block copolymers of poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-PPS) have recently emerged as a new macromolecular amphiphile capable of forming a wide range of morphologies when dispersed in water. To understand better the relationship between stability and morphology in terms of the relative and absolute block compositions, we have synthesized a collection of PEG-PPS block copolymers and quantified their critical aggregation concentration and observed their morphology using cryogenic transmission electron microscopy after thin film hydration with extrusion and after solvent dispersion from tetrahydrofuran, a solvent for both blocks. By understanding the relationship between aggregate character and block copolymer architecture, we have observed that whereas the relative block lengths control morphology, the stability of the aggregates upon dilution is determined by the absolute block length of the hydrophobic PPS block. We have compared results obtained with PEG-PPS to those obtained with poly(ethylene glycol)-blpoly(propylene oxide)-bl-poly(ethylene glycol) block copolymers (Pluronics). The results reveal that the PEG-PPS aggregates are substantially more stable than Pluronic aggregates, by more than an order of magnitude. PEG-PPS can form a wide variety of stable or metastable morphologies in dilute solution within normal time and temperature ranges, whereas Pluronics can generally form only spherical micelles under the same conditions. On the basis of these results, block copolymers of PEG with poly(propylene sulfide) may present distinct advantages over those with poly(propylene glycol) for a number of applications.

Original languageEnglish
Pages (from-to)11328-11335
Number of pages8
JournalLangmuir
Volume25
Issue number19
DOIs
StatePublished - Oct 6 2009
Externally publishedYes

Fingerprint

Propylene Glycol
Ethylene Glycol
Glycols
Ethylene glycol
propylene
Block copolymers
Propylene
sulfides
glycols
copolymers
ethylene
Agglomeration
Polyethylene glycols
aqueous solutions
Poloxamer
block copolymers
Polypropylenes
polypropylene
Amphiphiles
Micelles

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Cerritelli, S., O'neil, C. P., Velluto, D., Fontana, A., Adrian, M., Dubochet, J., & Hubbell, J. A. (2009). Aggregation behavior of poly(ethylene glycol-bl-propylene sulfide) di-And triblock copolymers in aqueous solution. Langmuir, 25(19), 11328-11335. https://doi.org/10.1021/la900649m

Aggregation behavior of poly(ethylene glycol-bl-propylene sulfide) di-And triblock copolymers in aqueous solution. / Cerritelli, Simona; O'neil, Conlin P.; Velluto, Diana; Fontana, Antonella; Adrian, Marc; Dubochet, Jacques; Hubbell, Jeffrey A.

In: Langmuir, Vol. 25, No. 19, 06.10.2009, p. 11328-11335.

Research output: Contribution to journalArticle

Cerritelli, S, O'neil, CP, Velluto, D, Fontana, A, Adrian, M, Dubochet, J & Hubbell, JA 2009, 'Aggregation behavior of poly(ethylene glycol-bl-propylene sulfide) di-And triblock copolymers in aqueous solution', Langmuir, vol. 25, no. 19, pp. 11328-11335. https://doi.org/10.1021/la900649m
Cerritelli S, O'neil CP, Velluto D, Fontana A, Adrian M, Dubochet J et al. Aggregation behavior of poly(ethylene glycol-bl-propylene sulfide) di-And triblock copolymers in aqueous solution. Langmuir. 2009 Oct 6;25(19):11328-11335. https://doi.org/10.1021/la900649m
Cerritelli, Simona ; O'neil, Conlin P. ; Velluto, Diana ; Fontana, Antonella ; Adrian, Marc ; Dubochet, Jacques ; Hubbell, Jeffrey A. / Aggregation behavior of poly(ethylene glycol-bl-propylene sulfide) di-And triblock copolymers in aqueous solution. In: Langmuir. 2009 ; Vol. 25, No. 19. pp. 11328-11335.
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