Agenesis of the arcuate fasciculi in congenital bilateral perisylvian syndrome: A diffusion tensor imaging and tractography study

Byron Bernal, Gustavo Rey, Catalina Dunoyer, Harshad Shanbhag, Nolan Altman

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Objective: To describe the absence of the arcuate fasciculi in 2 cases of congenital bilateral perisylvian syndrome (CBPS). Design: Case series. Setting: Pediatric referral hospital - based study. Patients: Two patients with CBPS, referred to our institution as candidates for surgical treatment of epilepsy. Intervention: Diffusion tensor imaging (1.5-T scanner; 15 encoding directions; b=800 s/mm2) and deterministic tractography of the main projection and association tracts. Main Outcome Measures: Neuropsychology evaluation; fractional anisotropy, apparent diffusion coefficients, and anatomical aspect of the tracts. Results: Absence of the arcuate fasciculus was observed in both subjects. Ancillary findings were complete absence of the superior longitudinal fasciculi in 1 case and underdevelopment in the other. Low fractional anisotropy of the left inferior occipitofrontal fasciculus was found in both cases. The same tract was maloriented in 1 of the cases. Conclusion: Agenesis of the arcuate fasciculus may accompany CBPS.

Original languageEnglish (US)
Pages (from-to)501-505
Number of pages5
JournalArchives of neurology
Volume67
Issue number4
DOIs
StatePublished - Apr 1 2010

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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