Ageing and obesity similarly impair antibody responses

Daniela Frasca, A. Diaz, M. Romero, Bonnie B Blomberg

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Ageing is characterized by increased low-grade chronic inflammation, which is a significant risk factor for morbidity and mortality of elderly individuals. Similar to ageing, obesity is considered to be an inflammatory predisposition associated with chronic activation of immune cells and consequent local and systemic inflammation. Both ageing and obesity are characterized by reduced innate and adaptive immune responses. This review focuses on B cells, how they may contribute, at least locally, to low-grade chronic inflammation in ageing and obesity and on the mechanisms involved.

Original languageEnglish (US)
JournalClinical and Experimental Immunology
DOIs
StateAccepted/In press - 2016

Fingerprint

Antibody Formation
Obesity
Inflammation
Adaptive Immunity
Innate Immunity
B-Lymphocytes
Morbidity
Mortality

Keywords

  • Ageing
  • B cells
  • Inflammation
  • Obesity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Ageing and obesity similarly impair antibody responses. / Frasca, Daniela; Diaz, A.; Romero, M.; Blomberg, Bonnie B.

In: Clinical and Experimental Immunology, 2016.

Research output: Contribution to journalArticle

@article{71f4a326f8e44397b8c381bf39e03393,
title = "Ageing and obesity similarly impair antibody responses",
abstract = "Ageing is characterized by increased low-grade chronic inflammation, which is a significant risk factor for morbidity and mortality of elderly individuals. Similar to ageing, obesity is considered to be an inflammatory predisposition associated with chronic activation of immune cells and consequent local and systemic inflammation. Both ageing and obesity are characterized by reduced innate and adaptive immune responses. This review focuses on B cells, how they may contribute, at least locally, to low-grade chronic inflammation in ageing and obesity and on the mechanisms involved.",
keywords = "Ageing, B cells, Inflammation, Obesity",
author = "Daniela Frasca and A. Diaz and M. Romero and Blomberg, {Bonnie B}",
year = "2016",
doi = "10.1111/cei.12824",
language = "English (US)",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Ageing and obesity similarly impair antibody responses

AU - Frasca, Daniela

AU - Diaz, A.

AU - Romero, M.

AU - Blomberg, Bonnie B

PY - 2016

Y1 - 2016

N2 - Ageing is characterized by increased low-grade chronic inflammation, which is a significant risk factor for morbidity and mortality of elderly individuals. Similar to ageing, obesity is considered to be an inflammatory predisposition associated with chronic activation of immune cells and consequent local and systemic inflammation. Both ageing and obesity are characterized by reduced innate and adaptive immune responses. This review focuses on B cells, how they may contribute, at least locally, to low-grade chronic inflammation in ageing and obesity and on the mechanisms involved.

AB - Ageing is characterized by increased low-grade chronic inflammation, which is a significant risk factor for morbidity and mortality of elderly individuals. Similar to ageing, obesity is considered to be an inflammatory predisposition associated with chronic activation of immune cells and consequent local and systemic inflammation. Both ageing and obesity are characterized by reduced innate and adaptive immune responses. This review focuses on B cells, how they may contribute, at least locally, to low-grade chronic inflammation in ageing and obesity and on the mechanisms involved.

KW - Ageing

KW - B cells

KW - Inflammation

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84994421934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994421934&partnerID=8YFLogxK

U2 - 10.1111/cei.12824

DO - 10.1111/cei.12824

M3 - Article

C2 - 27314456

AN - SCOPUS:84994421934

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

ER -