Ageing and obesity similarly impair antibody responses

Daniela Frasca, A. Diaz, M. Romero, Bonnie B Blomberg

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Ageing is characterized by increased low-grade chronic inflammation, which is a significant risk factor for morbidity and mortality of elderly individuals. Similar to ageing, obesity is considered to be an inflammatory predisposition associated with chronic activation of immune cells and consequent local and systemic inflammation. Both ageing and obesity are characterized by reduced innate and adaptive immune responses. This review focuses on B cells, how they may contribute, at least locally, to low-grade chronic inflammation in ageing and obesity and on the mechanisms involved.

Original languageEnglish (US)
JournalClinical and Experimental Immunology
DOIs
StateAccepted/In press - 2016

Keywords

  • Ageing
  • B cells
  • Inflammation
  • Obesity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Ageing and obesity similarly impair antibody responses'. Together they form a unique fingerprint.

  • Cite this