Ageing and genetic control of immune responsiveness

Gino Doria; Daniela Frasca

doi:10.1016/0165-2478(94)00061-1

Ageing and genetic control of immune responsiveness

Gino Doria, Daniela Frasca

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Ageing is associated with a progressive decline of immune responsiveness to exogenous antigens and increasing incidence of autoimmune phenomena [1,2]. Many studies have been focussed on the mechanisms of the immunologic features of ageing. Alterations in cellular components of the immune system rather than in the extracellular milieu seem to account for most of the variations of immune competence in ageing [3].

Original language	English (US)
Pages (from-to)	231-233
Number of pages	3
Journal	Immunology Letters
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/0165-2478(94)00061-1
State	Published - Jun 1 1994
Externally published	Yes

Keywords

Autoimmunity
Cell differentiation
Cell proliferation
Exogenous antigen
Interleukin-2
Thymus

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1016/0165-2478(94)00061-1

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author = "Gino Doria and Daniela Frasca",

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AU - Frasca, Daniela

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AB - Ageing is associated with a progressive decline of immune responsiveness to exogenous antigens and increasing incidence of autoimmune phenomena [1,2]. Many studies have been focussed on the mechanisms of the immunologic features of ageing. Alterations in cellular components of the immune system rather than in the extracellular milieu seem to account for most of the variations of immune competence in ageing [3].

KW - Autoimmunity

KW - Cell differentiation

KW - Cell proliferation

KW - Exogenous antigen

KW - Interleukin-2

KW - Thymus

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Ageing and genetic control of immune responsiveness

Abstract

Keywords

ASJC Scopus subject areas

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