Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function

Ron Golan, Jason M. Scovell, Ranjith Ramasamy

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Hypogonadism is a condition in which the endogenous secretion of testosterone is either insufficient or inadequate to maintain serum testosterone levels within normal range, and may manifest as a variety of signs and symptoms. Age-related hypogonadism is due to a combination of primary hypogonadism (testicular failure) and secondary hypogonadism (hypothalamic-pituitary axis failure). This review provides insight into the mechanisms resulting in the multifactorial nature of acquired androgen-deficiency, and outlines the current controversy regarding testosterone-replacement therapy in aging males.

Original languageEnglish (US)
Pages (from-to)201-204
Number of pages4
JournalAging Male
Volume18
Issue number3
DOIs
StatePublished - Jul 3 2015
Externally publishedYes

Keywords

  • Aging
  • hypogonadism
  • late-onset hypogonadism
  • testosterone

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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