Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function

Ron Golan, Jason M. Scovell, Ranjith Ramasamy

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Hypogonadism is a condition in which the endogenous secretion of testosterone is either insufficient or inadequate to maintain serum testosterone levels within normal range, and may manifest as a variety of signs and symptoms. Age-related hypogonadism is due to a combination of primary hypogonadism (testicular failure) and secondary hypogonadism (hypothalamic-pituitary axis failure). This review provides insight into the mechanisms resulting in the multifactorial nature of acquired androgen-deficiency, and outlines the current controversy regarding testosterone-replacement therapy in aging males.

Original languageEnglish (US)
Pages (from-to)201-204
Number of pages4
JournalAging Male
Volume18
Issue number3
DOIs
StatePublished - Jul 3 2015
Externally publishedYes

Fingerprint

Hypogonadism
Testosterone
Androgens
Signs and Symptoms
Reference Values
Serum
Therapeutics

Keywords

  • Aging
  • hypogonadism
  • late-onset hypogonadism
  • testosterone

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function. / Golan, Ron; Scovell, Jason M.; Ramasamy, Ranjith.

In: Aging Male, Vol. 18, No. 3, 03.07.2015, p. 201-204.

Research output: Contribution to journalArticle

@article{d0917ae8de2642b093e01b31912ec06a,
title = "Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function",
abstract = "Hypogonadism is a condition in which the endogenous secretion of testosterone is either insufficient or inadequate to maintain serum testosterone levels within normal range, and may manifest as a variety of signs and symptoms. Age-related hypogonadism is due to a combination of primary hypogonadism (testicular failure) and secondary hypogonadism (hypothalamic-pituitary axis failure). This review provides insight into the mechanisms resulting in the multifactorial nature of acquired androgen-deficiency, and outlines the current controversy regarding testosterone-replacement therapy in aging males.",
keywords = "Aging, hypogonadism, late-onset hypogonadism, testosterone",
author = "Ron Golan and Scovell, {Jason M.} and Ranjith Ramasamy",
year = "2015",
month = "7",
day = "3",
doi = "10.3109/13685538.2015.1052392",
language = "English (US)",
volume = "18",
pages = "201--204",
journal = "Aging Male",
issn = "1368-5538",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function

AU - Golan, Ron

AU - Scovell, Jason M.

AU - Ramasamy, Ranjith

PY - 2015/7/3

Y1 - 2015/7/3

N2 - Hypogonadism is a condition in which the endogenous secretion of testosterone is either insufficient or inadequate to maintain serum testosterone levels within normal range, and may manifest as a variety of signs and symptoms. Age-related hypogonadism is due to a combination of primary hypogonadism (testicular failure) and secondary hypogonadism (hypothalamic-pituitary axis failure). This review provides insight into the mechanisms resulting in the multifactorial nature of acquired androgen-deficiency, and outlines the current controversy regarding testosterone-replacement therapy in aging males.

AB - Hypogonadism is a condition in which the endogenous secretion of testosterone is either insufficient or inadequate to maintain serum testosterone levels within normal range, and may manifest as a variety of signs and symptoms. Age-related hypogonadism is due to a combination of primary hypogonadism (testicular failure) and secondary hypogonadism (hypothalamic-pituitary axis failure). This review provides insight into the mechanisms resulting in the multifactorial nature of acquired androgen-deficiency, and outlines the current controversy regarding testosterone-replacement therapy in aging males.

KW - Aging

KW - hypogonadism

KW - late-onset hypogonadism

KW - testosterone

UR - http://www.scopus.com/inward/record.url?scp=84942511748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942511748&partnerID=8YFLogxK

U2 - 10.3109/13685538.2015.1052392

DO - 10.3109/13685538.2015.1052392

M3 - Article

C2 - 26075536

AN - SCOPUS:84942511748

VL - 18

SP - 201

EP - 204

JO - Aging Male

JF - Aging Male

SN - 1368-5538

IS - 3

ER -