Age-related shift in brain region activity during successful memory performance

Erin A. Hazlett; M. S. Buchsbaum; R. C. Mohs; J. Spiegel-Cohen; T. C. Wei; R. Azueta; M. M. Haznedar; M. B. Singer; L. Shihabuddin; C. Luu-Hsia; P. D. Harvey

doi:10.1016/S0197-4580(98)00075-X

Age-related shift in brain region activity during successful memory performance

Erin A. Hazlett, M. S. Buchsbaum, R. C. Mohs, J. Spiegel-Cohen, T. C. Wei, R. Azueta, M. M. Haznedar, M. B. Singer, L. Shihabuddin, C. Luu-Hsia, P. D. Harvey

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

Coregistered positron emission tomography (PET)/magnetic resonance imaging (MRI) was used to characterize brain function in 70 volunteers, aged 20-87 years, during a verbal memory task. Frontal activity showed an age-related decline that remained significant after statistical control for sulcal atrophy. Analyses of young and old subgroups matched for memory scores revealed that young good performers activated frontal regions, whereas old good performers relied on occipital regions. Although activating different cortical regions, good performers of all ages used the same cognitive strategy-semantic clustering. Age-related functional change may reflect dynamic re-allocation in a network of brain areas, not merely anatomically fixed neuronal loss or diminished capacity to perform. Copyright (C) 1998 Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	437-445
Number of pages	9
Journal	Neurobiology of aging
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/S0197-4580(98)00075-X
State	Published - Sep 1 1998
Externally published	Yes

Keywords

Frontal lobe
Normal aging
Positron emission tomography
Regional glucose metabolism
Verbal memory

ASJC Scopus subject areas

Clinical Neurology
Biological Psychiatry
Developmental Neuroscience
Neurology
Psychology(all)

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Age-related shift in brain region activity during successful memory performance. / Hazlett, Erin A.; Buchsbaum, M. S.; Mohs, R. C.; Spiegel-Cohen, J.; Wei, T. C.; Azueta, R.; Haznedar, M. M.; Singer, M. B.; Shihabuddin, L.; Luu-Hsia, C.; Harvey, P. D.

In: Neurobiology of aging, Vol. 19, No. 5, 01.09.1998, p. 437-445.

Research output: Contribution to journal › Article › peer-review

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AU - Mohs, R. C.

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AU - Wei, T. C.

AU - Azueta, R.

AU - Haznedar, M. M.

AU - Singer, M. B.

AU - Shihabuddin, L.

AU - Luu-Hsia, C.

AU - Harvey, P. D.

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AB - Coregistered positron emission tomography (PET)/magnetic resonance imaging (MRI) was used to characterize brain function in 70 volunteers, aged 20-87 years, during a verbal memory task. Frontal activity showed an age-related decline that remained significant after statistical control for sulcal atrophy. Analyses of young and old subgroups matched for memory scores revealed that young good performers activated frontal regions, whereas old good performers relied on occipital regions. Although activating different cortical regions, good performers of all ages used the same cognitive strategy-semantic clustering. Age-related functional change may reflect dynamic re-allocation in a network of brain areas, not merely anatomically fixed neuronal loss or diminished capacity to perform. Copyright (C) 1998 Elsevier Science Inc.

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KW - Normal aging

KW - Positron emission tomography

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KW - Verbal memory

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Age-related shift in brain region activity during successful memory performance

Abstract

Keywords

ASJC Scopus subject areas

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