Riduzione età-correlata del precondizionamento ischemico: Ruolo dell'attività fisica e della restrizione calorica

Translated title of the contribution: Age-related reduction of ischemic preconditioning: Role of the physical activity and caloric restriction

Pasquale Abete, David Della Morte, F. Mazzella, G. Galizia, D. D'Ambrosio, G. Gargiulo, V. Del Villano, G. Testa, L. Viati, F. Cacciatore, F. Rengo

Research output: Contribution to journalArticle

Abstract

Ischemic preconditioning, the most powerful endogenous protective mechanism against cardiac ischemia-reperfusion injury, is reduced with aging. The mechanism responsible for the age-related reduction of ischemic preconditioning seems to be the reduction of norepinephrine release from cardiac adrenergic terminations in response to ischemic preconditioning stimulus. The age-related reduction of ischemic preconditioning is also evident in elderly patients: preinfarction angina, a clinical equivalent of ischemic preconditioning, reduces mortality in adult but not in elderly patients with acute myocardial infarction. Physical activity or caloric restriction are partially capable to preserve the cardioprotective effect of ischemic preconditioning in the aging heart. More importantly, physical activity and caloric restriction in tandem action completely preserve the protective mechanism of ischemic preconditioning. Accordingly, the protective mechanism of preinfarction angina is preserved in elderly patients with a high grade of physical activity or a low level of body-mass index. Thus, both physical activity and caloric restriction are confirmed as powerful anti-aging interventions capable to restore age-dependent reduction of a critical endogenous protective mechanism, such as ischemic preconditioning.

Original languageItalian
Pages (from-to)324-332
Number of pages9
JournalGiornale di Gerontologia
Volume53
Issue number5
StatePublished - Oct 1 2005
Externally publishedYes

Fingerprint

Caloric Restriction
Ischemic Preconditioning
Exercise
Unstable Angina
Reperfusion Injury
Adrenergic Agents
Norepinephrine
Body Mass Index
Myocardial Infarction
Mortality

Keywords

  • Caloric restriction
  • Ischemic preconditioning
  • Myocardial infarction
  • Physical activity

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Abete, P., Della Morte, D., Mazzella, F., Galizia, G., D'Ambrosio, D., Gargiulo, G., ... Rengo, F. (2005). Riduzione età-correlata del precondizionamento ischemico: Ruolo dell'attività fisica e della restrizione calorica. Giornale di Gerontologia, 53(5), 324-332.

Riduzione età-correlata del precondizionamento ischemico : Ruolo dell'attività fisica e della restrizione calorica. / Abete, Pasquale; Della Morte, David; Mazzella, F.; Galizia, G.; D'Ambrosio, D.; Gargiulo, G.; Del Villano, V.; Testa, G.; Viati, L.; Cacciatore, F.; Rengo, F.

In: Giornale di Gerontologia, Vol. 53, No. 5, 01.10.2005, p. 324-332.

Research output: Contribution to journalArticle

Abete, P, Della Morte, D, Mazzella, F, Galizia, G, D'Ambrosio, D, Gargiulo, G, Del Villano, V, Testa, G, Viati, L, Cacciatore, F & Rengo, F 2005, 'Riduzione età-correlata del precondizionamento ischemico: Ruolo dell'attività fisica e della restrizione calorica', Giornale di Gerontologia, vol. 53, no. 5, pp. 324-332.
Abete, Pasquale ; Della Morte, David ; Mazzella, F. ; Galizia, G. ; D'Ambrosio, D. ; Gargiulo, G. ; Del Villano, V. ; Testa, G. ; Viati, L. ; Cacciatore, F. ; Rengo, F. / Riduzione età-correlata del precondizionamento ischemico : Ruolo dell'attività fisica e della restrizione calorica. In: Giornale di Gerontologia. 2005 ; Vol. 53, No. 5. pp. 324-332.
@article{4ba93c080344460e977dfbe7c6b153b4,
title = "Riduzione et{\`a}-correlata del precondizionamento ischemico: Ruolo dell'attivit{\`a} fisica e della restrizione calorica",
abstract = "Ischemic preconditioning, the most powerful endogenous protective mechanism against cardiac ischemia-reperfusion injury, is reduced with aging. The mechanism responsible for the age-related reduction of ischemic preconditioning seems to be the reduction of norepinephrine release from cardiac adrenergic terminations in response to ischemic preconditioning stimulus. The age-related reduction of ischemic preconditioning is also evident in elderly patients: preinfarction angina, a clinical equivalent of ischemic preconditioning, reduces mortality in adult but not in elderly patients with acute myocardial infarction. Physical activity or caloric restriction are partially capable to preserve the cardioprotective effect of ischemic preconditioning in the aging heart. More importantly, physical activity and caloric restriction in tandem action completely preserve the protective mechanism of ischemic preconditioning. Accordingly, the protective mechanism of preinfarction angina is preserved in elderly patients with a high grade of physical activity or a low level of body-mass index. Thus, both physical activity and caloric restriction are confirmed as powerful anti-aging interventions capable to restore age-dependent reduction of a critical endogenous protective mechanism, such as ischemic preconditioning.",
keywords = "Caloric restriction, Ischemic preconditioning, Myocardial infarction, Physical activity",
author = "Pasquale Abete and {Della Morte}, David and F. Mazzella and G. Galizia and D. D'Ambrosio and G. Gargiulo and {Del Villano}, V. and G. Testa and L. Viati and F. Cacciatore and F. Rengo",
year = "2005",
month = "10",
day = "1",
language = "Italian",
volume = "53",
pages = "324--332",
journal = "Giornale di Gerontologia",
issn = "0017-0305",
publisher = "Pacini Editore s.r.l.",
number = "5",

}

TY - JOUR

T1 - Riduzione età-correlata del precondizionamento ischemico

T2 - Ruolo dell'attività fisica e della restrizione calorica

AU - Abete, Pasquale

AU - Della Morte, David

AU - Mazzella, F.

AU - Galizia, G.

AU - D'Ambrosio, D.

AU - Gargiulo, G.

AU - Del Villano, V.

AU - Testa, G.

AU - Viati, L.

AU - Cacciatore, F.

AU - Rengo, F.

PY - 2005/10/1

Y1 - 2005/10/1

N2 - Ischemic preconditioning, the most powerful endogenous protective mechanism against cardiac ischemia-reperfusion injury, is reduced with aging. The mechanism responsible for the age-related reduction of ischemic preconditioning seems to be the reduction of norepinephrine release from cardiac adrenergic terminations in response to ischemic preconditioning stimulus. The age-related reduction of ischemic preconditioning is also evident in elderly patients: preinfarction angina, a clinical equivalent of ischemic preconditioning, reduces mortality in adult but not in elderly patients with acute myocardial infarction. Physical activity or caloric restriction are partially capable to preserve the cardioprotective effect of ischemic preconditioning in the aging heart. More importantly, physical activity and caloric restriction in tandem action completely preserve the protective mechanism of ischemic preconditioning. Accordingly, the protective mechanism of preinfarction angina is preserved in elderly patients with a high grade of physical activity or a low level of body-mass index. Thus, both physical activity and caloric restriction are confirmed as powerful anti-aging interventions capable to restore age-dependent reduction of a critical endogenous protective mechanism, such as ischemic preconditioning.

AB - Ischemic preconditioning, the most powerful endogenous protective mechanism against cardiac ischemia-reperfusion injury, is reduced with aging. The mechanism responsible for the age-related reduction of ischemic preconditioning seems to be the reduction of norepinephrine release from cardiac adrenergic terminations in response to ischemic preconditioning stimulus. The age-related reduction of ischemic preconditioning is also evident in elderly patients: preinfarction angina, a clinical equivalent of ischemic preconditioning, reduces mortality in adult but not in elderly patients with acute myocardial infarction. Physical activity or caloric restriction are partially capable to preserve the cardioprotective effect of ischemic preconditioning in the aging heart. More importantly, physical activity and caloric restriction in tandem action completely preserve the protective mechanism of ischemic preconditioning. Accordingly, the protective mechanism of preinfarction angina is preserved in elderly patients with a high grade of physical activity or a low level of body-mass index. Thus, both physical activity and caloric restriction are confirmed as powerful anti-aging interventions capable to restore age-dependent reduction of a critical endogenous protective mechanism, such as ischemic preconditioning.

KW - Caloric restriction

KW - Ischemic preconditioning

KW - Myocardial infarction

KW - Physical activity

UR - http://www.scopus.com/inward/record.url?scp=72049105830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72049105830&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:72049105830

VL - 53

SP - 324

EP - 332

JO - Giornale di Gerontologia

JF - Giornale di Gerontologia

SN - 0017-0305

IS - 5

ER -