Age-related modulation of cytokine production, IL-2R expression and function in a population of healthy subjects (22 to 97 years)

Daniela Frasca, L. Guidi, C. Bartoloni, A. Tricerri, M. Vangeli, L. Antico, P. U. Carbonin, A. Errani, G. Doria

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have investigated the role of cytokine production and recognition in the age-related impairment of cell proliferative responses. Peripheral blood mononuclear cells (PBM) from a continuous population of 38 healthy subjects aged 22-97 years (20 healthy adults and 18 institutionalized elderly subjects selected according to the SE-NIEUR EURAGE protocol) were mitogen activated, and their ability to synthesize IL-2 and IL-4, to express the membrane-bound IL-2R, or to release its soluble form in culture supernatant was studied. Results suggest that reduction in the synthesis of IL-2 and IL-4 and in the release of the soluble form of IL-2R significantly contribute to the decrease in T cell proliferative responses observed with aging. However, T cell blasts stimulated with an excess of IL-2 display an increase in their ability to proliferate, suggesting that aging may not significantly alter cell proliferation if adequate amounts of cytokines are provided.

Original languageEnglish
Pages (from-to)3-12
Number of pages10
JournalAging: Immunology and Infectious Disease
Volume5
Issue number1
StatePublished - Dec 1 1994
Externally publishedYes

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Interleukin-2
Healthy Volunteers
Cytokines
Interleukin-4
Population
T-Lymphocytes
Mitogens
Blood Cells
Cell Proliferation
Membranes

ASJC Scopus subject areas

  • Aging
  • Immunology

Cite this

Age-related modulation of cytokine production, IL-2R expression and function in a population of healthy subjects (22 to 97 years). / Frasca, Daniela; Guidi, L.; Bartoloni, C.; Tricerri, A.; Vangeli, M.; Antico, L.; Carbonin, P. U.; Errani, A.; Doria, G.

In: Aging: Immunology and Infectious Disease, Vol. 5, No. 1, 01.12.1994, p. 3-12.

Research output: Contribution to journalArticle

Frasca, D, Guidi, L, Bartoloni, C, Tricerri, A, Vangeli, M, Antico, L, Carbonin, PU, Errani, A & Doria, G 1994, 'Age-related modulation of cytokine production, IL-2R expression and function in a population of healthy subjects (22 to 97 years)', Aging: Immunology and Infectious Disease, vol. 5, no. 1, pp. 3-12.
Frasca, Daniela ; Guidi, L. ; Bartoloni, C. ; Tricerri, A. ; Vangeli, M. ; Antico, L. ; Carbonin, P. U. ; Errani, A. ; Doria, G. / Age-related modulation of cytokine production, IL-2R expression and function in a population of healthy subjects (22 to 97 years). In: Aging: Immunology and Infectious Disease. 1994 ; Vol. 5, No. 1. pp. 3-12.
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