Abstract
The in vitro serum protein binding of quinidine was determined in 26 pediatric patients. Group I consisted of 6 cord blood samples obtained at the time of delivery, group II of 8 infants aged 8-18 months, and group III of 12 children over the age of 2 years. The percentage of free quinidine in group I was 39.2 ± 10.8, group II 24.4 ± 10.6 and group III 16.6 ± 6.5, demonstrating a larger proportion of unbound quinidine in the newborn group and an increase in protein binding with age (p<0.0001). Therefore, the protein binding of quinidine is diminished in the neonate and young infant and may result in enhanced quinidine activity.
| Original language | English |
|---|---|
| Pages (from-to) | 108-115 |
| Number of pages | 8 |
| Journal | Developmental Pharmacology and Therapeutics |
| Volume | 3 |
| Issue number | 2 |
| State | Published - Dec 29 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
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Age-related differences in the protein binding of quinidine. / Pickoff, A. S.; Kessler, K. M.; Singh, S.; Wolff, G. S.; Tamer, D. F.; Garcia, O. L.; Gelband, H.
In: Developmental Pharmacology and Therapeutics, Vol. 3, No. 2, 29.12.1981, p. 108-115.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-related differences in the protein binding of quinidine
AU - Pickoff, A. S.
AU - Kessler, K. M.
AU - Singh, S.
AU - Wolff, G. S.
AU - Tamer, D. F.
AU - Garcia, O. L.
AU - Gelband, H.
PY - 1981/12/29
Y1 - 1981/12/29
N2 - The in vitro serum protein binding of quinidine was determined in 26 pediatric patients. Group I consisted of 6 cord blood samples obtained at the time of delivery, group II of 8 infants aged 8-18 months, and group III of 12 children over the age of 2 years. The percentage of free quinidine in group I was 39.2 ± 10.8, group II 24.4 ± 10.6 and group III 16.6 ± 6.5, demonstrating a larger proportion of unbound quinidine in the newborn group and an increase in protein binding with age (p<0.0001). Therefore, the protein binding of quinidine is diminished in the neonate and young infant and may result in enhanced quinidine activity.
AB - The in vitro serum protein binding of quinidine was determined in 26 pediatric patients. Group I consisted of 6 cord blood samples obtained at the time of delivery, group II of 8 infants aged 8-18 months, and group III of 12 children over the age of 2 years. The percentage of free quinidine in group I was 39.2 ± 10.8, group II 24.4 ± 10.6 and group III 16.6 ± 6.5, demonstrating a larger proportion of unbound quinidine in the newborn group and an increase in protein binding with age (p<0.0001). Therefore, the protein binding of quinidine is diminished in the neonate and young infant and may result in enhanced quinidine activity.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019446724&partnerID=8YFLogxK
M3 - Article
C2 - 7318638
AN - SCOPUS:0019446724
VL - 3
SP - 108
EP - 115
JO - Developmental Pharmacology and Therapeutics
JF - Developmental Pharmacology and Therapeutics
SN - 0379-8305
IS - 2
ER -