Age-related differences in the protein binding of quinidine

A. S. Pickoff, K. M. Kessler, S. Singh, G. S. Wolff, D. F. Tamer, O. L. Garcia, H. Gelband

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The in vitro serum protein binding of quinidine was determined in 26 pediatric patients. Group I consisted of 6 cord blood samples obtained at the time of delivery, group II of 8 infants aged 8-18 months, and group III of 12 children over the age of 2 years. The percentage of free quinidine in group I was 39.2 ± 10.8, group II 24.4 ± 10.6 and group III 16.6 ± 6.5, demonstrating a larger proportion of unbound quinidine in the newborn group and an increase in protein binding with age (p<0.0001). Therefore, the protein binding of quinidine is diminished in the neonate and young infant and may result in enhanced quinidine activity.

Original languageEnglish
Pages (from-to)108-115
Number of pages8
JournalDevelopmental Pharmacology and Therapeutics
Issue number2
StatePublished - Dec 29 1981
Externally publishedYes


ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Pickoff, A. S., Kessler, K. M., Singh, S., Wolff, G. S., Tamer, D. F., Garcia, O. L., & Gelband, H. (1981). Age-related differences in the protein binding of quinidine. Developmental Pharmacology and Therapeutics, 3(2), 108-115.