Age-related differences in the protein binding of quinidine

A. S. Pickoff, K. M. Kessler, S. Singh, G. S. Wolff, D. F. Tamer, O. L. Garcia, H. Gelband

Research output: Contribution to journalArticle

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Abstract

The in vitro serum protein binding of quinidine was determined in 26 pediatric patients. Group I consisted of 6 cord blood samples obtained at the time of delivery, group II of 8 infants aged 8-18 months, and group III of 12 children over the age of 2 years. The percentage of free quinidine in group I was 39.2 ± 10.8, group II 24.4 ± 10.6 and group III 16.6 ± 6.5, demonstrating a larger proportion of unbound quinidine in the newborn group and an increase in protein binding with age (p<0.0001). Therefore, the protein binding of quinidine is diminished in the neonate and young infant and may result in enhanced quinidine activity.

Original languageEnglish
Pages (from-to)108-115
Number of pages8
JournalDevelopmental Pharmacology and Therapeutics
Volume3
Issue number2
StatePublished - Dec 29 1981
Externally publishedYes

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Quinidine
Protein Binding
Newborn Infant
Fetal Blood
Blood Proteins
Pediatrics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Pickoff, A. S., Kessler, K. M., Singh, S., Wolff, G. S., Tamer, D. F., Garcia, O. L., & Gelband, H. (1981). Age-related differences in the protein binding of quinidine. Developmental Pharmacology and Therapeutics, 3(2), 108-115.

Age-related differences in the protein binding of quinidine. / Pickoff, A. S.; Kessler, K. M.; Singh, S.; Wolff, G. S.; Tamer, D. F.; Garcia, O. L.; Gelband, H.

In: Developmental Pharmacology and Therapeutics, Vol. 3, No. 2, 29.12.1981, p. 108-115.

Research output: Contribution to journalArticle

Pickoff, AS, Kessler, KM, Singh, S, Wolff, GS, Tamer, DF, Garcia, OL & Gelband, H 1981, 'Age-related differences in the protein binding of quinidine', Developmental Pharmacology and Therapeutics, vol. 3, no. 2, pp. 108-115.
Pickoff AS, Kessler KM, Singh S, Wolff GS, Tamer DF, Garcia OL et al. Age-related differences in the protein binding of quinidine. Developmental Pharmacology and Therapeutics. 1981 Dec 29;3(2):108-115.
Pickoff, A. S. ; Kessler, K. M. ; Singh, S. ; Wolff, G. S. ; Tamer, D. F. ; Garcia, O. L. ; Gelband, H. / Age-related differences in the protein binding of quinidine. In: Developmental Pharmacology and Therapeutics. 1981 ; Vol. 3, No. 2. pp. 108-115.
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