Abstract
The in vitro serum protein binding of quinidine was determined in 26 pediatric patients. Group I consisted of 6 cord blood samples obtained at the time of delivery, group II of 8 infants aged 8-18 months, and group III of 12 children over the age of 2 years. The percentage of free quinidine in group I was 39.2 ± 10.8, group II 24.4 ± 10.6 and group III 16.6 ± 6.5, demonstrating a larger proportion of unbound quinidine in the newborn group and an increase in protein binding with age (p<0.0001). Therefore, the protein binding of quinidine is diminished in the neonate and young infant and may result in enhanced quinidine activity.
| Original language | English |
|---|---|
| Pages (from-to) | 108-115 |
| Number of pages | 8 |
| Journal | Developmental Pharmacology and Therapeutics |
| Volume | 3 |
| Issue number | 2 |
| State | Published - Dec 29 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Pickoff, A. S., Kessler, K. M., Singh, S., Wolff, G. S., Tamer, D. F., Garcia, O. L., & Gelband, H. (1981). Age-related differences in the protein binding of quinidine. Developmental Pharmacology and Therapeutics, 3(2), 108-115.