Age-related differences in the protein binding of quinidine

A. S. Pickoff; K. M. Kessler; S. Singh; G. S. Wolff; D. F. Tamer; O. L. Garcia; H. Gelband

doi:10.1159/000457429

Age-related differences in the protein binding of quinidine

A. S. Pickoff, K. M. Kessler, S. Singh, G. S. Wolff, D. F. Tamer, O. L. Garcia, H. Gelband

Pediatrics

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The in vitro serum protein binding of quinidine was determined in 26 pediatric patients. Group I consisted of 6 cord blood samples obtained at the time of delivery, group II of 8 infants aged 8-18 months, and group III of 12 children over the age of 2 years. The percentage of free quinidine in group I was 39.2 ± 10.8, group II 24.4 ± 10.6 and group III 16.6 ± 6.5, demonstrating a larger proportion of unbound quinidine in the newborn group and an increase in protein binding with age (p<0.0001). Therefore, the protein binding of quinidine is diminished in the neonate and young infant and may result in enhanced quinidine activity.

Original language	English (US)
Pages (from-to)	108-115
Number of pages	8
Journal	Unknown Journal
Volume	3
Issue number	2
DOIs	https://doi.org/10.1159/000457429
State	Published - Jan 1 1981

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)

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title = "Age-related differences in the protein binding of quinidine",

abstract = "The in vitro serum protein binding of quinidine was determined in 26 pediatric patients. Group I consisted of 6 cord blood samples obtained at the time of delivery, group II of 8 infants aged 8-18 months, and group III of 12 children over the age of 2 years. The percentage of free quinidine in group I was 39.2 ± 10.8, group II 24.4 ± 10.6 and group III 16.6 ± 6.5, demonstrating a larger proportion of unbound quinidine in the newborn group and an increase in protein binding with age (p<0.0001). Therefore, the protein binding of quinidine is diminished in the neonate and young infant and may result in enhanced quinidine activity.",

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T1 - Age-related differences in the protein binding of quinidine

AU - Pickoff, A. S.

AU - Kessler, K. M.

AU - Singh, S.

AU - Wolff, G. S.

AU - Tamer, D. F.

AU - Garcia, O. L.

AU - Gelband, H.

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AB - The in vitro serum protein binding of quinidine was determined in 26 pediatric patients. Group I consisted of 6 cord blood samples obtained at the time of delivery, group II of 8 infants aged 8-18 months, and group III of 12 children over the age of 2 years. The percentage of free quinidine in group I was 39.2 ± 10.8, group II 24.4 ± 10.6 and group III 16.6 ± 6.5, demonstrating a larger proportion of unbound quinidine in the newborn group and an increase in protein binding with age (p<0.0001). Therefore, the protein binding of quinidine is diminished in the neonate and young infant and may result in enhanced quinidine activity.

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