Age-related changes in tear menisci imaged by optical coherence tomography

Lele Cui, Meixiao Shen, Jianhua Wang, Jun Jiang, Ming Li, Ding Chen, Zhao Chen, Aizhu Tao, Fan Lu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose.: To determine age-related changes of tear menisci in healthy subjects and to compare tear variables between age-matched normals and dry eye subjects. Methods.: Anterior segment optical coherence tomography was used to measure upper and lower tear menisci in healthy subjects (n = 197, 8-83 years) and in age-matched dry eye patients (n = 38, 19-72 years). Measured tear variables included the height and area of the tear meniscus. Tear meniscus volumes were calculated based on the cross-sectional areas of the tear menisci and the eyelid lengths. The age-related decrease rates of the tear menisci were also calculated. Results.: There were significant negative correlations between age and all tear meniscus dimensions (r ranged from -0.649 to -0.753; p < 0.05) in the healthy group. The rate of decrease for the total tear meniscus volume in healthy subjects was 1.0% per year. Compared with age-matched healthy subjects, the height, cross-sectional area, and volume of the upper and lower tear menisci in dry eye subjects were significantly smaller (p < 0.05). Conclusions.: Tear menisci decreased with age in the healthy group. The variables in age-matched dry eye subjects were significantly lower than those in the healthy group.

Original languageEnglish
Pages (from-to)1214-1219
Number of pages6
JournalOptometry and Vision Science
Volume88
Issue number10
DOIs
StatePublished - Oct 1 2011

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Optical Coherence Tomography
Tears
Healthy Volunteers
Meniscus
Eyelids

Keywords

  • age
  • optical coherence tomography
  • Tear meniscus volume

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry
  • Medicine(all)

Cite this

Age-related changes in tear menisci imaged by optical coherence tomography. / Cui, Lele; Shen, Meixiao; Wang, Jianhua; Jiang, Jun; Li, Ming; Chen, Ding; Chen, Zhao; Tao, Aizhu; Lu, Fan.

In: Optometry and Vision Science, Vol. 88, No. 10, 01.10.2011, p. 1214-1219.

Research output: Contribution to journalArticle

Cui, L, Shen, M, Wang, J, Jiang, J, Li, M, Chen, D, Chen, Z, Tao, A & Lu, F 2011, 'Age-related changes in tear menisci imaged by optical coherence tomography', Optometry and Vision Science, vol. 88, no. 10, pp. 1214-1219. https://doi.org/10.1097/OPX.0b013e3182271297
Cui, Lele ; Shen, Meixiao ; Wang, Jianhua ; Jiang, Jun ; Li, Ming ; Chen, Ding ; Chen, Zhao ; Tao, Aizhu ; Lu, Fan. / Age-related changes in tear menisci imaged by optical coherence tomography. In: Optometry and Vision Science. 2011 ; Vol. 88, No. 10. pp. 1214-1219.
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