Age-related changes in tear menisci imaged by optical coherence tomography

Lele Cui, Meixiao Shen, Jianhua Wang, Jun Jiang, Ming Li, Ding Chen, Zhao Chen, Aizhu Tao, Fan Lu

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Purpose.: To determine age-related changes of tear menisci in healthy subjects and to compare tear variables between age-matched normals and dry eye subjects. Methods.: Anterior segment optical coherence tomography was used to measure upper and lower tear menisci in healthy subjects (n = 197, 8-83 years) and in age-matched dry eye patients (n = 38, 19-72 years). Measured tear variables included the height and area of the tear meniscus. Tear meniscus volumes were calculated based on the cross-sectional areas of the tear menisci and the eyelid lengths. The age-related decrease rates of the tear menisci were also calculated. Results.: There were significant negative correlations between age and all tear meniscus dimensions (r ranged from -0.649 to -0.753; p < 0.05) in the healthy group. The rate of decrease for the total tear meniscus volume in healthy subjects was 1.0% per year. Compared with age-matched healthy subjects, the height, cross-sectional area, and volume of the upper and lower tear menisci in dry eye subjects were significantly smaller (p < 0.05). Conclusions.: Tear menisci decreased with age in the healthy group. The variables in age-matched dry eye subjects were significantly lower than those in the healthy group.

Original languageEnglish (US)
Pages (from-to)1214-1219
Number of pages6
JournalOptometry and Vision Science
Volume88
Issue number10
DOIs
StatePublished - Oct 1 2011

Keywords

  • age
  • optical coherence tomography
  • Tear meniscus volume

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry
  • Medicine(all)

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  • Cite this

    Cui, L., Shen, M., Wang, J., Jiang, J., Li, M., Chen, D., Chen, Z., Tao, A., & Lu, F. (2011). Age-related changes in tear menisci imaged by optical coherence tomography. Optometry and Vision Science, 88(10), 1214-1219. https://doi.org/10.1097/OPX.0b013e3182271297