Age of disease onset influences cognition in Parkinson's disease

Heather L. Katzen, Bonnie E. Levin, Maria L. Llabre

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

It is controversial whether age of disease onset is related to cognitive decline in Parkinson's disease (PD). We administered 7 cognitive measures assessing visuospatial skills, memory, and executive functions to 222 patients with idiopathic PD and 108 normal control participants. Regression analyses demonstrated that older age of disease onset consistently predicted cognitive decline above and beyond normative aging and duration of illness. These findings suggest that older age of disease onset is a critical determinant of cognitive deterioration in PD.

Original languageEnglish (US)
Pages (from-to)285-290
Number of pages6
JournalJournal of the International Neuropsychological Society
Volume4
Issue number3
DOIs
StatePublished - May 1998

Keywords

  • Age of onset
  • Cognition
  • Cognitive decline
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

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