Age, gender, and autonomic tone effects on surface electrocardiographic indices of ventricular repolarization

Taresh Taneja, Jennifer Larsen, Jeffrey Goldberger, Alan Kadish

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Prolonged QT offset dispersion (QToD), an index of heterogeneity of ventricular repolarization, is thought to be an independent predictor of all-cause and cardiovascular mortality. However the influence of gender and autonomic tone in healthy adults on age-related changes in measures of ventricular repolarization are not well characterized. Methods: QToD and T wave complexity were measured in 56 healthy subjects with no detectable heart disease (by echo and stress test) - 38 young subjects with a mean age of 28 ± 4 years and 18 old subjects with a mean age of 71 ± 7 years. QToD and T wave complexity were computed from 12-lead ECGs using the GE Marquette QT Guard automated analysis program with manual over-reading at rest (baseline), following exercise, and double autonomic blockade with atropine and propranolol. Data was analyzed using factorial ANOVA. Results: Young males had a significantly greater QToD than young and old females at baseline (28 ± 5 ms, 23 ± 5 ms, and 22 ± 5 ms, respectively, P < 0.01), an intrinsic effect independent of changes in autonomic tone. In contrast, females had significantly greater T wave complexity than males following exercise and double autonomic blockade with a definite trend at baseline. There was no correlation between T wave complexity and QToD. Conclusions: Age and gender demonstrate a complex interaction on indices of myocardial repolarization with different measures behaving differently. These findings have implications for better understanding age and gender effects on myocardial electrophysiology.

Original languageEnglish (US)
Pages (from-to)290-297
Number of pages8
JournalAnnals of Noninvasive Electrocardiology
Volume6
Issue number4
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Autonomic Agents
Exercise
Electrophysiology
Atropine
Exercise Test
Propranolol
Reading
Heart Diseases
Analysis of Variance
Healthy Volunteers
Electrocardiography
Mortality
Lead

Keywords

  • Age
  • Autonomic
  • Gender
  • Repolarization
  • Ventricular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Age, gender, and autonomic tone effects on surface electrocardiographic indices of ventricular repolarization. / Taneja, Taresh; Larsen, Jennifer; Goldberger, Jeffrey; Kadish, Alan.

In: Annals of Noninvasive Electrocardiology, Vol. 6, No. 4, 01.01.2001, p. 290-297.

Research output: Contribution to journalArticle

@article{e41198ef2881496f901c59fcddf1d382,
title = "Age, gender, and autonomic tone effects on surface electrocardiographic indices of ventricular repolarization",
abstract = "Background: Prolonged QT offset dispersion (QToD), an index of heterogeneity of ventricular repolarization, is thought to be an independent predictor of all-cause and cardiovascular mortality. However the influence of gender and autonomic tone in healthy adults on age-related changes in measures of ventricular repolarization are not well characterized. Methods: QToD and T wave complexity were measured in 56 healthy subjects with no detectable heart disease (by echo and stress test) - 38 young subjects with a mean age of 28 ± 4 years and 18 old subjects with a mean age of 71 ± 7 years. QToD and T wave complexity were computed from 12-lead ECGs using the GE Marquette QT Guard automated analysis program with manual over-reading at rest (baseline), following exercise, and double autonomic blockade with atropine and propranolol. Data was analyzed using factorial ANOVA. Results: Young males had a significantly greater QToD than young and old females at baseline (28 ± 5 ms, 23 ± 5 ms, and 22 ± 5 ms, respectively, P < 0.01), an intrinsic effect independent of changes in autonomic tone. In contrast, females had significantly greater T wave complexity than males following exercise and double autonomic blockade with a definite trend at baseline. There was no correlation between T wave complexity and QToD. Conclusions: Age and gender demonstrate a complex interaction on indices of myocardial repolarization with different measures behaving differently. These findings have implications for better understanding age and gender effects on myocardial electrophysiology.",
keywords = "Age, Autonomic, Gender, Repolarization, Ventricular",
author = "Taresh Taneja and Jennifer Larsen and Jeffrey Goldberger and Alan Kadish",
year = "2001",
month = "1",
day = "1",
doi = "10.1111/j.1542-474X.2001.tb00121.x",
language = "English (US)",
volume = "6",
pages = "290--297",
journal = "Annals of Noninvasive Electrocardiology",
issn = "1082-720X",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Age, gender, and autonomic tone effects on surface electrocardiographic indices of ventricular repolarization

AU - Taneja, Taresh

AU - Larsen, Jennifer

AU - Goldberger, Jeffrey

AU - Kadish, Alan

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Background: Prolonged QT offset dispersion (QToD), an index of heterogeneity of ventricular repolarization, is thought to be an independent predictor of all-cause and cardiovascular mortality. However the influence of gender and autonomic tone in healthy adults on age-related changes in measures of ventricular repolarization are not well characterized. Methods: QToD and T wave complexity were measured in 56 healthy subjects with no detectable heart disease (by echo and stress test) - 38 young subjects with a mean age of 28 ± 4 years and 18 old subjects with a mean age of 71 ± 7 years. QToD and T wave complexity were computed from 12-lead ECGs using the GE Marquette QT Guard automated analysis program with manual over-reading at rest (baseline), following exercise, and double autonomic blockade with atropine and propranolol. Data was analyzed using factorial ANOVA. Results: Young males had a significantly greater QToD than young and old females at baseline (28 ± 5 ms, 23 ± 5 ms, and 22 ± 5 ms, respectively, P < 0.01), an intrinsic effect independent of changes in autonomic tone. In contrast, females had significantly greater T wave complexity than males following exercise and double autonomic blockade with a definite trend at baseline. There was no correlation between T wave complexity and QToD. Conclusions: Age and gender demonstrate a complex interaction on indices of myocardial repolarization with different measures behaving differently. These findings have implications for better understanding age and gender effects on myocardial electrophysiology.

AB - Background: Prolonged QT offset dispersion (QToD), an index of heterogeneity of ventricular repolarization, is thought to be an independent predictor of all-cause and cardiovascular mortality. However the influence of gender and autonomic tone in healthy adults on age-related changes in measures of ventricular repolarization are not well characterized. Methods: QToD and T wave complexity were measured in 56 healthy subjects with no detectable heart disease (by echo and stress test) - 38 young subjects with a mean age of 28 ± 4 years and 18 old subjects with a mean age of 71 ± 7 years. QToD and T wave complexity were computed from 12-lead ECGs using the GE Marquette QT Guard automated analysis program with manual over-reading at rest (baseline), following exercise, and double autonomic blockade with atropine and propranolol. Data was analyzed using factorial ANOVA. Results: Young males had a significantly greater QToD than young and old females at baseline (28 ± 5 ms, 23 ± 5 ms, and 22 ± 5 ms, respectively, P < 0.01), an intrinsic effect independent of changes in autonomic tone. In contrast, females had significantly greater T wave complexity than males following exercise and double autonomic blockade with a definite trend at baseline. There was no correlation between T wave complexity and QToD. Conclusions: Age and gender demonstrate a complex interaction on indices of myocardial repolarization with different measures behaving differently. These findings have implications for better understanding age and gender effects on myocardial electrophysiology.

KW - Age

KW - Autonomic

KW - Gender

KW - Repolarization

KW - Ventricular

UR - http://www.scopus.com/inward/record.url?scp=0034756124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034756124&partnerID=8YFLogxK

U2 - 10.1111/j.1542-474X.2001.tb00121.x

DO - 10.1111/j.1542-474X.2001.tb00121.x

M3 - Article

VL - 6

SP - 290

EP - 297

JO - Annals of Noninvasive Electrocardiology

JF - Annals of Noninvasive Electrocardiology

SN - 1082-720X

IS - 4

ER -