Age effects on mouse and human B cells

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Our laboratory has contributed to the areas of B cell receptor (BCR) and pre-BCR gene identification and transcription and has focused on the problem of the aged immune system in mice and humans for the last 15 years. We have found biomarkers for the decrease in B cell function in aged mice and humans these include decreases in immunoglobulin (Ig) class switch (e.g., IgM to IgG), decreases in the enzyme AID (activation-induced cytidine deaminase) and decreases in the transcription factor E47 the E47 mRNA stability is decreased in old B cells due to decreased phospho-MAPKinase and phospho-TTP (tristetraprolin). Inflammation, e.g., TNF-α, which increases with age, impacts B cells directly by increasing their TNF-α and NF-κB and leads to the above decreased pathway. Both class switch and affinity maturation are decreased in elderly responses to the influenza vaccine and biomarkers we have found (numbers and percentages of switched memory B cells and AID in stimulated B cells in culture) can predict a beneficial or decreased immune response to the vaccine. Current and future avenues to improve the humoral immune response in the elderly are discussed.

Original languageEnglish
Pages (from-to)354-360
Number of pages7
JournalImmunologic Research
Volume57
Issue number1-3
DOIs
StatePublished - Dec 1 2013

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B-Lymphocytes
Pre-B Cell Receptors
Tristetraprolin
Biomarkers
Enzyme Activation
Immunoglobulin Isotypes
Influenza Vaccines
RNA Stability
Humoral Immunity
Immunoglobulin M
Immune System
Transcription Factors
Vaccines
Cell Culture Techniques
Immunoglobulin G
Inflammation
Genes
AICDA (activation-induced cytidine deaminase)

Keywords

  • Aging
  • Antibody production
  • B cells
  • Transcription factors
  • Vaccines

ASJC Scopus subject areas

  • Immunology

Cite this

Age effects on mouse and human B cells. / Blomberg, Bonnie B; Frasca, Daniela.

In: Immunologic Research, Vol. 57, No. 1-3, 01.12.2013, p. 354-360.

Research output: Contribution to journalArticle

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