Age effects on B cells and humoral immunity in humans

Daniela Frasca; Alain Diaz; Maria Romero; Ana Marie Landin; Bonnie B. Blomberg

doi:10.1016/j.arr.2010.08.004

Age effects on B cells and humoral immunity in humans

Daniela Frasca, Alain Diaz, Maria Romero, Ana Marie Landin, Bonnie B. Blomberg

Microbiology & Immunology

Research output: Contribution to journal › Review article

119 Scopus citations

Abstract

Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging.

Original language	English (US)
Pages (from-to)	330-335
Number of pages	6
Journal	Ageing Research Reviews
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/j.arr.2010.08.004
State	Published - Jul 1 2011

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Keywords

Aging
B lymphocytes
Immunoglobulin class switch
Influenza vaccination

ASJC Scopus subject areas

Aging
Biochemistry
Biotechnology
Molecular Biology
Neurology

Cite this

Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2011). Age effects on B cells and humoral immunity in humans. Ageing Research Reviews, 10(3), 330-335. https://doi.org/10.1016/j.arr.2010.08.004

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Access to Document

10.1016/j.arr.2010.08.004