Abstract
Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging.
Original language | English (US) |
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Pages (from-to) | 330-335 |
Number of pages | 6 |
Journal | Ageing Research Reviews |
Volume | 10 |
Issue number | 3 |
DOIs | |
State | Published - Jul 2011 |
Keywords
- Aging
- B lymphocytes
- Immunoglobulin class switch
- Influenza vaccination
ASJC Scopus subject areas
- Aging
- Biochemistry
- Biotechnology
- Molecular Biology
- Neurology