Abstract
Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging.
| Original language | English |
|---|---|
| Pages (from-to) | 330-335 |
| Number of pages | 6 |
| Journal | Ageing Research Reviews |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 1 2011 |
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Keywords
- Aging
- B lymphocytes
- Immunoglobulin class switch
- Influenza vaccination
ASJC Scopus subject areas
- Aging
- Biochemistry
- Biotechnology
- Molecular Biology
- Neurology
Cite this
Age effects on B cells and humoral immunity in humans. / Frasca, Daniela; Diaz, Alain; Romero, Maria; Landin, Ana Marie; Blomberg, Bonnie B.
In: Ageing Research Reviews, Vol. 10, No. 3, 01.07.2011, p. 330-335.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age effects on B cells and humoral immunity in humans
AU - Frasca, Daniela
AU - Diaz, Alain
AU - Romero, Maria
AU - Landin, Ana Marie
AU - Blomberg, Bonnie B
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging.
AB - Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging.
KW - Aging
KW - B lymphocytes
KW - Immunoglobulin class switch
KW - Influenza vaccination
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U2 - 10.1016/j.arr.2010.08.004
DO - 10.1016/j.arr.2010.08.004
M3 - Article
VL - 10
SP - 330
EP - 335
JO - Ageing Research Reviews
JF - Ageing Research Reviews
SN - 1568-1637
IS - 3
ER -