Age effects on B cells and humoral immunity in humans

Daniela Frasca, Alain Diaz, Maria Romero, Ana Marie Landin, Bonnie B Blomberg

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging.

Original languageEnglish
Pages (from-to)330-335
Number of pages6
JournalAgeing Research Reviews
Volume10
Issue number3
DOIs
StatePublished - Jul 1 2011

Fingerprint

Humoral Immunity
B-Lymphocytes
Cells
Genetic Recombination
Switches
Defects
T-cells
Cell Aging
Cellular Immunity
Transcription Factors
Vaccines
Aging of materials
T-Lymphocytes
Enzymes

Keywords

  • Aging
  • B lymphocytes
  • Immunoglobulin class switch
  • Influenza vaccination

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Neurology

Cite this

Age effects on B cells and humoral immunity in humans. / Frasca, Daniela; Diaz, Alain; Romero, Maria; Landin, Ana Marie; Blomberg, Bonnie B.

In: Ageing Research Reviews, Vol. 10, No. 3, 01.07.2011, p. 330-335.

Research output: Contribution to journalArticle

Frasca, Daniela ; Diaz, Alain ; Romero, Maria ; Landin, Ana Marie ; Blomberg, Bonnie B. / Age effects on B cells and humoral immunity in humans. In: Ageing Research Reviews. 2011 ; Vol. 10, No. 3. pp. 330-335.
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