Age effects on B cells and humoral immunity in humans

Daniela Frasca, Alain Diaz, Maria Romero, Ana Marie Landin, Bonnie B. Blomberg

Research output: Contribution to journalReview articlepeer-review

169 Scopus citations


Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging.

Original languageEnglish (US)
Pages (from-to)330-335
Number of pages6
JournalAgeing Research Reviews
Issue number3
StatePublished - Jul 2011


  • Aging
  • B lymphocytes
  • Immunoglobulin class switch
  • Influenza vaccination

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Neurology


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