Age effects on B cells and humoral immunity in humans

Daniela Frasca; Alain Diaz; Maria Romero; Ana Marie Landin; Bonnie B. Blomberg

doi:10.1016/j.arr.2010.08.004

Age effects on B cells and humoral immunity in humans

Daniela Frasca, Alain Diaz, Maria Romero, Ana Marie Landin, Bonnie B. Blomberg

Microbiology & Immunology

Research output: Contribution to journal › Review article › peer-review

140 Scopus citations

Abstract

Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging.

Original language	English (US)
Pages (from-to)	330-335
Number of pages	6
Journal	Ageing Research Reviews
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/j.arr.2010.08.004
State	Published - Jul 2011

Keywords

Aging
B lymphocytes
Immunoglobulin class switch
Influenza vaccination

ASJC Scopus subject areas

Aging
Biochemistry
Biotechnology
Molecular Biology
Neurology

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title = "Age effects on B cells and humoral immunity in humans",

abstract = "Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging.",

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AU - Frasca, Daniela

AU - Diaz, Alain

AU - Romero, Maria

AU - Landin, Ana Marie

AU - Blomberg, Bonnie B.

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AB - Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging.

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KW - Immunoglobulin class switch

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Age effects on B cells and humoral immunity in humans

Abstract

Keywords

ASJC Scopus subject areas

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