Age differences in intercorrelations between regional cerebral metabolic rates for glucose

B. Horwitz, R. Duara, S. I. Rapoport

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Patterns of cerebral metabolic intercorrelations were compared in the resting state in 15 healthy young men (ages 20 to 32 years) and 15 healthy elderly men (ages 64 to 83 years). Controlling for whole-brain glucose metabolism partial correlation coefficients were determined between pairs of regional cerebral metabolic rates for glucose determined by positron emission tomography using {18F}fluorodeoxyglucose and obtained in 59 brain regions. Compared with the young men, the elderly men had fewer statistically significant correlations, with the most notable reductions observed between the parietal lobe regions, and between the parietal and frontal lobe regions. These results suggest that cerebral functional interactions are reduced in healthy elderly men.

Original languageEnglish
Pages (from-to)60-67
Number of pages8
JournalAnnals of Neurology
Volume19
Issue number1
StatePublished - Jan 1 1986
Externally publishedYes

Fingerprint

Parietal Lobe
Glucose
Fluorodeoxyglucose F18
Brain
Frontal Lobe
Positron-Emission Tomography

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Age differences in intercorrelations between regional cerebral metabolic rates for glucose. / Horwitz, B.; Duara, R.; Rapoport, S. I.

In: Annals of Neurology, Vol. 19, No. 1, 01.01.1986, p. 60-67.

Research output: Contribution to journalArticle

Horwitz, B, Duara, R & Rapoport, SI 1986, 'Age differences in intercorrelations between regional cerebral metabolic rates for glucose', Annals of Neurology, vol. 19, no. 1, pp. 60-67.
Horwitz, B. ; Duara, R. ; Rapoport, S. I. / Age differences in intercorrelations between regional cerebral metabolic rates for glucose. In: Annals of Neurology. 1986 ; Vol. 19, No. 1. pp. 60-67.
@article{883675e5d6494b489a68d9cb861f5b41,
title = "Age differences in intercorrelations between regional cerebral metabolic rates for glucose",
abstract = "Patterns of cerebral metabolic intercorrelations were compared in the resting state in 15 healthy young men (ages 20 to 32 years) and 15 healthy elderly men (ages 64 to 83 years). Controlling for whole-brain glucose metabolism partial correlation coefficients were determined between pairs of regional cerebral metabolic rates for glucose determined by positron emission tomography using {18F}fluorodeoxyglucose and obtained in 59 brain regions. Compared with the young men, the elderly men had fewer statistically significant correlations, with the most notable reductions observed between the parietal lobe regions, and between the parietal and frontal lobe regions. These results suggest that cerebral functional interactions are reduced in healthy elderly men.",
author = "B. Horwitz and R. Duara and Rapoport, {S. I.}",
year = "1986",
month = "1",
day = "1",
language = "English",
volume = "19",
pages = "60--67",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Age differences in intercorrelations between regional cerebral metabolic rates for glucose

AU - Horwitz, B.

AU - Duara, R.

AU - Rapoport, S. I.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - Patterns of cerebral metabolic intercorrelations were compared in the resting state in 15 healthy young men (ages 20 to 32 years) and 15 healthy elderly men (ages 64 to 83 years). Controlling for whole-brain glucose metabolism partial correlation coefficients were determined between pairs of regional cerebral metabolic rates for glucose determined by positron emission tomography using {18F}fluorodeoxyglucose and obtained in 59 brain regions. Compared with the young men, the elderly men had fewer statistically significant correlations, with the most notable reductions observed between the parietal lobe regions, and between the parietal and frontal lobe regions. These results suggest that cerebral functional interactions are reduced in healthy elderly men.

AB - Patterns of cerebral metabolic intercorrelations were compared in the resting state in 15 healthy young men (ages 20 to 32 years) and 15 healthy elderly men (ages 64 to 83 years). Controlling for whole-brain glucose metabolism partial correlation coefficients were determined between pairs of regional cerebral metabolic rates for glucose determined by positron emission tomography using {18F}fluorodeoxyglucose and obtained in 59 brain regions. Compared with the young men, the elderly men had fewer statistically significant correlations, with the most notable reductions observed between the parietal lobe regions, and between the parietal and frontal lobe regions. These results suggest that cerebral functional interactions are reduced in healthy elderly men.

UR - http://www.scopus.com/inward/record.url?scp=0022621005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022621005&partnerID=8YFLogxK

M3 - Article

C2 - 3484930

AN - SCOPUS:0022621005

VL - 19

SP - 60

EP - 67

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 1

ER -