Age-dependent Changes in the Macular Choriocapillaris of Normal Eyes Imaged With Swept-Source Optical Coherence Tomography Angiography

Fang Zheng, Qinqin Zhang, Yingying Shi, Jonathan F. Russell, Elie H. Motulsky, James T. Banta, Zhongdi Chu, Hao Zhou, Nimesh A. Patel, Luis de Sisternes, Mary K. Durbin, William Feuer, Giovanni Gregori, Ruikang Wang, Philip J. Rosenfeld

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Purpose: Swept-source optical coherence tomography angiography (SS-OCTA) was used to measure the age-dependent changes in macular choriocapillaris (CC) flow deficits (FDs) in normal eyes. Design: A prospective, cross-sectional study. Methods: Subjects with normal eyes ranging in age from their 20s to their 80s were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000, Carl Zeiss Meditec, Dublin, California, USA). Both 3 × 3-mm and 6 × 6-mm scans were used to image the macular CC. Visualization of the CC and quantification of FDs were performed using a previously validated algorithm. The percentage of FDs (FD%) in the central 1-mm circle (C 1 ), 1.5-mm rim (R 1.5 ), and 2.5-mm circle (C 2.5 ) from the 3 × 3-mm and 6 × 6-mm scans and FD% in the 2.5-mm rim (R 2.5 ) and 5-mm circle (C 5 ) from the 6 × 6-mm scans were measured and correlated with age and axial length. Results: A total of 164 subjects were enrolled, with at least 10 subjects from each decade of life. No meaningful correlations were found between FD% and axial length (|r| < 0.30). FD% in all fields increased with increasing age (all r > 0.50; all P <.001); however, the greatest increases were found in the central macula C 1 regions and the smallest increases in the peripheral macula R 2.5 regions. Conclusions: In normal aging, the FD% increased with age across the central 5 mm of the macula, but the greatest increase was found in the central 1-mm region of the macula.

Original languageEnglish (US)
Pages (from-to)110-122
Number of pages13
JournalAmerican journal of ophthalmology
Volume200
DOIs
StatePublished - Apr 2019

ASJC Scopus subject areas

  • Ophthalmology

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