Age at onset in two common neurodegenerative diseases is genetically controlled

Yi Ju Li, William K. Scott, Dale J. Hedges, Fengyu Zhang, P. Craig Gaskell, Martha A. Nance, Ray L. Watts, Jean P. Hubble, William C. Koller, Rajesh Pahwa, Matthew B. Stern, Bradley C. Hiner, Joseph Jankovic, Fred H. Allen, Christopher G. Goetz, Frank Mastaglia, Jeffrey M. Stajich, Rachel A. Gibson, Lefkos T. Middleton, Ann M. SaundersBurton L. Scott, Gary W. Small, Kristin K. Nicodemus, Allison D. Reed, Donald E. Schmechel, Kathleen A. Welsh-Bohmer, P. Michael Conneally, Allen D. Roses, John R. Gilbert, Jeffery M. Vance, Jonathan L. Haines, Margaret A. Pericak-Vance

Research output: Contribution to journalArticlepeer-review

259 Scopus citations

Abstract

To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n = 449) and Parkinson disease (PD; n = 174). Heritabilities between 40%-60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D1051239 and D1051237, with a maximum LOD score of 2.62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)985-993
Number of pages9
JournalAmerican journal of human genetics
Volume70
Issue number4
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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