@article{c61447b031084819bfe7c1f5d1933b2d,
title = "Age at onset in two common neurodegenerative diseases is genetically controlled",
abstract = "To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n = 449) and Parkinson disease (PD; n = 174). Heritabilities between 40%-60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D1051239 and D1051237, with a maximum LOD score of 2.62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.",
author = "Li, {Yi Ju} and Scott, {William K.} and Hedges, {Dale J.} and Fengyu Zhang and Gaskell, {P. Craig} and Nance, {Martha A.} and Watts, {Ray L.} and Hubble, {Jean P.} and Koller, {William C.} and Rajesh Pahwa and Stern, {Matthew B.} and Hiner, {Bradley C.} and Joseph Jankovic and Allen, {Fred H.} and Goetz, {Christopher G.} and Frank Mastaglia and Stajich, {Jeffrey M.} and Gibson, {Rachel A.} and Middleton, {Lefkos T.} and Saunders, {Ann M.} and Scott, {Burton L.} and Small, {Gary W.} and Nicodemus, {Kristin K.} and Reed, {Allison D.} and Schmechel, {Donald E.} and Welsh-Bohmer, {Kathleen A.} and Conneally, {P. Michael} and Roses, {Allen D.} and Gilbert, {John R.} and Vance, {Jeffery M.} and Haines, {Jonathan L.} and Pericak-Vance, {Margaret A.}",
note = "Funding Information: We thank the patients with AD and PD and their families, whose help and participation made this work possible, as well as the clinical and research personnel of the Center for Human Genetics at Duke University Medical Center, the Program in Human Genetics at Vanderbilt University Medical Center, and the Joseph and the Kathleen Bryan ADRC. This work was supported by grants NS31153, AG05128, P50-AG-05128, AG13308, AG11268, AG10123, MH52453, P01 NS26630, and P50 NS39764 from the National Institutes of Health; grant M01 RR00865 from the U.S. Public Health Service; grant 95-23330 from the California Department of Health Services; grants IIRG94101 and IRG2-96044 from the Fran and Ray Stark Foundation Fund for Alzheimer's Disease Research; a T. L. L. Temple Award (TLL-97-012); and Zenith Awards from the Alzheimer's Disease and Related Disorders Association and GlaxoSmithKline, Inc. ",
year = "2002",
doi = "10.1086/339815",
language = "English (US)",
volume = "70",
pages = "985--993",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "4",
}