Age at onset in two common neurodegenerative diseases is genetically controlled

Yi Ju Li; William K. Scott; Dale J. Hedges; Fengyu Zhang; P. Craig Gaskell; Martha A. Nance; Ray L. Watts; Jean P. Hubble; William C. Koller; Rajesh Pahwa; Matthew B. Stern; Bradley C. Hiner; Joseph Jankovic; Fred H. Allen; Christopher G. Goetz; Frank Mastaglia; Jeffrey M. Stajich; Rachel A. Gibson; Lefkos T. Middleton; Ann M. Saunders; Burton L. Scott; Gary W. Small; Kristin K. Nicodemus; Allison D. Reed; Donald E. Schmechel; Kathleen A. Welsh-Bohmer; P. Michael Conneally; Allen D. Roses; John R. Gilbert; Jeffery M. Vance; Jonathan L. Haines; Margaret A. Pericak-Vance

doi:10.1086/339815

Age at onset in two common neurodegenerative diseases is genetically controlled

Yi Ju Li, William K. Scott, Dale J. Hedges, Fengyu Zhang, P. Craig Gaskell, Martha A. Nance, Ray L. Watts, Jean P. Hubble, William C. Koller, Rajesh Pahwa, Matthew B. Stern, Bradley C. Hiner, Joseph Jankovic, Fred H. Allen, Christopher G. Goetz, Frank Mastaglia, Jeffrey M. Stajich, Rachel A. Gibson, Lefkos T. Middleton, Ann M. SaundersBurton L. Scott, Gary W. Small, Kristin K. Nicodemus, Allison D. Reed, Donald E. Schmechel, Kathleen A. Welsh-Bohmer, P. Michael Conneally, Allen D. Roses, John R. Gilbert, Jeffery M. Vance, Jonathan L. Haines, Margaret A. Pericak-Vance

Hussman Institute for Human Genomics

Research output: Contribution to journal › Article › peer-review

259 Scopus citations

Abstract

To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n = 449) and Parkinson disease (PD; n = 174). Heritabilities between 40%-60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D1051239 and D1051237, with a maximum LOD score of 2.62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.

Original language	English (US)
Pages (from-to)	985-993
Number of pages	9
Journal	American journal of human genetics
Volume	70
Issue number	4
DOIs	https://doi.org/10.1086/339815
State	Published - 2002

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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Li, Y. J., Scott, W. K., Hedges, D. J., Zhang, F., Gaskell, P. C., Nance, M. A., Watts, R. L., Hubble, J. P., Koller, W. C., Pahwa, R., Stern, M. B., Hiner, B. C., Jankovic, J., Allen, F. H., Goetz, C. G., Mastaglia, F., Stajich, J. M., Gibson, R. A., Middleton, L. T., ... Pericak-Vance, M. A. (2002). Age at onset in two common neurodegenerative diseases is genetically controlled. American journal of human genetics, 70(4), 985-993. https://doi.org/10.1086/339815

Age at onset in two common neurodegenerative diseases is genetically controlled. / Li, Yi Ju; Scott, William K.; Hedges, Dale J.; Zhang, Fengyu; Gaskell, P. Craig; Nance, Martha A.; Watts, Ray L.; Hubble, Jean P.; Koller, William C.; Pahwa, Rajesh; Stern, Matthew B.; Hiner, Bradley C.; Jankovic, Joseph; Allen, Fred H.; Goetz, Christopher G.; Mastaglia, Frank; Stajich, Jeffrey M.; Gibson, Rachel A.; Middleton, Lefkos T.; Saunders, Ann M.; Scott, Burton L.; Small, Gary W.; Nicodemus, Kristin K.; Reed, Allison D.; Schmechel, Donald E.; Welsh-Bohmer, Kathleen A.; Conneally, P. Michael; Roses, Allen D.; Gilbert, John R.; Vance, Jeffery M.; Haines, Jonathan L.; Pericak-Vance, Margaret A.

In: American journal of human genetics, Vol. 70, No. 4, 2002, p. 985-993.

Research output: Contribution to journal › Article › peer-review

Li, YJ, Scott, WK, Hedges, DJ, Zhang, F, Gaskell, PC, Nance, MA, Watts, RL, Hubble, JP, Koller, WC, Pahwa, R, Stern, MB, Hiner, BC, Jankovic, J, Allen, FH, Goetz, CG, Mastaglia, F, Stajich, JM, Gibson, RA, Middleton, LT, Saunders, AM, Scott, BL, Small, GW, Nicodemus, KK, Reed, AD, Schmechel, DE, Welsh-Bohmer, KA, Conneally, PM, Roses, AD, Gilbert, JR, Vance, JM, Haines, JL & Pericak-Vance, MA 2002, 'Age at onset in two common neurodegenerative diseases is genetically controlled', American journal of human genetics, vol. 70, no. 4, pp. 985-993. https://doi.org/10.1086/339815

Li, Yi Ju ; Scott, William K. ; Hedges, Dale J. ; Zhang, Fengyu ; Gaskell, P. Craig ; Nance, Martha A. ; Watts, Ray L. ; Hubble, Jean P. ; Koller, William C. ; Pahwa, Rajesh ; Stern, Matthew B. ; Hiner, Bradley C. ; Jankovic, Joseph ; Allen, Fred H. ; Goetz, Christopher G. ; Mastaglia, Frank ; Stajich, Jeffrey M. ; Gibson, Rachel A. ; Middleton, Lefkos T. ; Saunders, Ann M. ; Scott, Burton L. ; Small, Gary W. ; Nicodemus, Kristin K. ; Reed, Allison D. ; Schmechel, Donald E. ; Welsh-Bohmer, Kathleen A. ; Conneally, P. Michael ; Roses, Allen D. ; Gilbert, John R. ; Vance, Jeffery M. ; Haines, Jonathan L. ; Pericak-Vance, Margaret A. / Age at onset in two common neurodegenerative diseases is genetically controlled. In: American journal of human genetics. 2002 ; Vol. 70, No. 4. pp. 985-993.

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abstract = "To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n = 449) and Parkinson disease (PD; n = 174). Heritabilities between 40%-60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D1051239 and D1051237, with a maximum LOD score of 2.62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.",

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AU - Scott, Burton L.

AU - Small, Gary W.

AU - Nicodemus, Kristin K.

AU - Reed, Allison D.

AU - Schmechel, Donald E.

AU - Welsh-Bohmer, Kathleen A.

AU - Conneally, P. Michael

AU - Roses, Allen D.

AU - Gilbert, John R.

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AU - Haines, Jonathan L.

AU - Pericak-Vance, Margaret A.

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